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Page 39 of 44

  1. Mutations in the mouse formin (Fmn) gene result in limb deformities and incompletely penetrant renal aplasia. A molecular genetic approach was taken to characterize novel circular RNAs from the Fmn gene and to un...

    Authors: Cindy Wang Chao, David C. Chan, Ann Kuo and Philip Leder
    Citation: Molecular Medicine 1998 4:BF03401761
  2. Laminin-5 (ln-5), a large heterotrimeric glycoprotein consisting of an α3, β3, and γ2 chain, is a component of epithelial cell basement membranes that functions as a ligand of the α3βl and α6β4 integrins to regul...

    Authors: Katherine J. Martin, Chi-Pong Kwan, Koichi Nagasaki, Xiaohong Zhang, Michael J. O’Hare, Carolyn M. Kaelin, Robert E. Burgeson, Arthur B. Pardee and Ruth Sager
    Citation: Molecular Medicine 1998 4:BF03401760
  3. In rheumatoid arthritis (RA), B-lineage cells in the synovial membrane secrete large amounts of immunoglobulin that contribute to tissue destruction. The CDR3 of an immunoglobulin light chain is formed by rear...

    Authors: S. Louis Bridges Jr.
    Citation: Molecular Medicine 1998 4:BF03401757
  4. Hereditary argininemia manifests as neurological disturbance and mental retardation, features not observed in other amino acidemias. The cytotoxic effect of a high concentration of L-arginine (L-Arg) was investig...

    Authors: Sachiko Todoroki, Shinji Goto, Yoshishige Urata, Kazuki Komatsu, Koji Sumikawa, Tsutomu Ogura, Ichiro Matsuda and Takahito Kondo
    Citation: Molecular Medicine 1998 4:BF03401756
  5. The 12 kD FK506 binding protein FKBP12 is a cytosolic receptor for the immunosuppressant drugs FK506 and rapamycin. In addition to its critical role in drug-induced T-cell immunosuppression, FKBP12 associates ...

    Authors: Loren D. Walensky, Ted M. Dawson, Joseph P. Steiner, David M. Sabatini, Juan D. Suarez, Gary R. Klinefelter and Solomon H. Snyder
    Citation: Molecular Medicine 1998 4:BF03401755
  6. The non-obese diabetic (NOD) mouse is a model of human type 1 diabetes in which autoreactive T cells mediate destruction of pancreatic islet β cells. Although known to be triggered by cytotoxic T cells, apoptosis...

    Authors: Petra Augstein, Leigh A. Stephens, Janette Allison, Andrew G. Elefanty, Merryn Ekberg, Thomas W. H. Kay and Leonard C. Harrison
    Citation: Molecular Medicine 1998 4:BF03401754
  7. Aside from numerous parenchymal and vascular deposits of amyloid β (Aβ) peptide, neurofibrillary tangles, and neuronal and synaptic loss, the neuropathology of Alzheimer’s disease is accompanied by a subtle and c...

    Authors: Milan Fiala, Ling Zhang, Xiaohu Gan, Barbara Sherry, Dennis Taub, Michael C. Graves, Suzan Hama, Dennis Way, Martin Weinand, Marlys Witte, Diane Lorton, Yu-Min Kuo and Alex E. Roher
    Citation: Molecular Medicine 1998 4:BF03401753
  8. Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with at least eight complementation groups (A–H). Two of the FA genes (FAA and FAC) have been cloned, and mutations in these genes acco...

    Authors: Michael Pulsipher, Gary M. Kupfer, Dieter Naf, Ahmed Suliman, Jeng-Shin Lee, Petra Jakobs, Markus Grompe, Hans Joenje, Colin Sieff, Eva Guinan, Richard Mulligan and Alan D. D’Andrea
    Citation: Molecular Medicine 1998 4:BF03401752
  9. The receptor (ER) for estrogen (E2) is routinely assayed as a marker to determine the feasibility of anti-hormone therapy against breast cancer because ER-positive (ER+) tumors are much more likely to respond ...

    Authors: Debajit K. Biswas, Lidia Averboukh, Shijie Sheng, Kathy Martin, Darren S. Ewaniuk, Teddy F. Jawde, Feilan Wang and Arthur B. Pardee
    Citation: Molecular Medicine 1998 4:BF03401751
  10. Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine that also counter-regulates glucocorticoid action. We investigated whether immunoneutralization of MIF could reverse establish...

    Authors: Niansheng Yang, David J. Nikolic-Paterson, Yee-Yung Ng, Wei Mu, Christine Metz, Michael Bacher, Andreas Meinhardt, Richard Bucala, Robert C. Atkins and Hui Y. Lan
    Citation: Molecular Medicine 1998 4:BF03401748
  11. Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes a 442 amino acid polypeptide-desig-nated viral interferon regulatory factor (vIRF) that displays homology to members of the interferon regulatory factor (...

    Authors: C. Clay Flowers, Scarlett P. Flowers and Gary J. Nabel
    Citation: Molecular Medicine 1998 4:BF03401747
  12. Members of the Ets family of winged helix-loop-helix transcription factors play important roles in the development and function of multiple mammalian cell lineages. Elf-1 is an Ets-related transcription factor...

    Authors: Alexander G. Bassuk, Kevin P. Barton, Roshani T. Anandappa, Min M. Lu and Jeffrey M. Leiden
    Citation: Molecular Medicine 1998 4:BF03401746
  13. 3B3 is a high-affinity anti-gp120 antibody that neutralizes a wide range of primary and laboratory isolates of HIV-1. The parental antibody was isolated from a combinatorial phage display library constructed f...

    Authors: Tapan K. Bera, Paul E. Kennedy, Edward A. Berger, Carlos F. Barbas and Ira Pastan
    Citation: Molecular Medicine 1998 4:BF03401745
  14. Curcumin is a small-molecular-weight compound that is isolated from the commonly used spice turmeric. In animal models, curcumin and its derivatives have been shown to inhibit the progression of chemically ind...

    Authors: Jack L. Arbiser, Nancy Klauber, Richard Rohan, Robert van Leeuwen, Mou-Tuan Huang, Carolyn Fisher, Evelyn Flynn and H. Randolph Byers
    Citation: Molecular Medicine 1998 4:BF03401744
  15. Collagen V plays a major regulatory role in the formation of heterotypic fibers of the dermis and cartilaginous tissues as well as in the assembly of extracellular matrix. The pN/pN mouse, which is defective i...

    Authors: Robert G. Phelps, Chihiro Murai, Shinichiro Saito, Akira Hatakeyama, Konstantinos Andrikopoulos, Kuppuswamy N. Kasturi and Constantin A. Bona
    Citation: Molecular Medicine 1998 4:BF03401742
  16. The pathogenesis of asthma is believed to reflect antigen-induced airway inflammation leading to the recruitment of eosinophils and activation of mast cells through cell-associated IgE. Controversies persist h...

    Authors: David B. Corry, Gabriele Grünig, Husein Hadeiba, Viswanath P. Kurup, Martha L. Warnock, Dean Sheppard, Donna M. Rennick, Richard M. Locksley and R. Locksley
    Citation: Molecular Medicine 1998 4:BF03401741
  17. HIV-1-infected patients are in chronic oxidative stress and clastogenic factors (CFs) are present in their plasma. CFs from patients with HIV are formed via superoxide anion radical and stimulate further super...

    Authors: Jürgen Fuchs, Nicole Oelke, Matthias Imhof, Falk Ochsendorf, Helmut Schöfer, Gerhard Oromek, Amina Alaoui-Youssefi and Ingrid Emerit
    Citation: Molecular Medicine 1998 4:BF03401740
  18. Massive neurofilament conglomeration in motor neurons has been described to occur in the early stages of both familial and sporadic amyotrophic lateral sclerosis (ALS). Previously, neurofilament conglomerates ...

    Authors: Samuel M. Chou, Helen S. Wang, Akira Taniguchi and Richard Bucala
    Citation: Molecular Medicine 1998 4:BF03401739
  19. Phosphoinositolglycan molecules isolated from insulin-sensitive mammalian tissues have been demonstrated in numerous in vitro studies to exert partial insulin-mimetic activity on glucose and lipid metabolism i...

    Authors: Günter Müller, Susanne Wied, Christine Piossek, Andrea Bauer, Jochen Bauer and Wendelin Frick
    Citation: Molecular Medicine 1998 4:BF03401738
  20. Lung surfactant protein A (SP-A) is a complex molecule composed of up to 18 polypeptide chains. In vivo, SP-A probably binds to a wide range of inhaled materials via the interaction of surface carbohydrates wi...

    Authors: Timothy P. Hickling, Rajneesh Malhotra and Robert B. Sim
    Citation: Molecular Medicine 1998 4:BF03401923
  21. The ion pump Na+,K+-ATPase is responsible for the secretion of cerebrospinal fluid from the choroid plexus. In this tissue, the activity of Na+,K+-ATPase is inhibited by serotonin via stimulation of protein kinas...

    Authors: Gilberto Fisone, Gretchen L. Snyder, Anita Aperia and Paul Greengard
    Citation: Molecular Medicine 1998 4:BF03401922
  22. Synovia of patients with long-standing rheumatoid arthritis (RA) are typically infiltrated with B lymphocytes and plasma cells that secrete large amounts of immunoglobulin. The CDR3 of an immunoglobulin heavy ...

    Authors: Björn E. Clausen, S. Louis Bridges Jr., John C. Lavelle, Priscilla G. Fowler, Steffen Gay, William J. Koopman and Harry W. Schroeder Jr.
    Citation: Molecular Medicine 1998 4:BF03401921
  23. The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides in autoantigens have potential diagnostic and therapeutic applications, and they...

    Authors: Margo C. Honeyman, Natalie L. Stone and Leonard C. Harrison
    Citation: Molecular Medicine 1998 4:BF03401920
  24. The mediator known historically as macrophage migration inhibitory factor (MIF) has been identified recently as being released into the circulation by the anterior pituitary gland as a consequence of stress or...

    Authors: Michael Bacher, Andreas Meinhardt, Hui Y. Lan, Firdaus S. Dhabhar, Wei Mu, Christine N. Metz, Jason A. Chesney, Diethard Gemsa, Thomas Donnelly, Robert C. Atkins and Richard Bucala
    Citation: Molecular Medicine 1998 4:BF03401919
  25. Patients with recessive dystrophic epidermolysis bullosa (RDEB) have deficiencies of collagen type VII and have elevated levels of fibroblast collagenase, and a greatly increased risk of cutaneous squamous cel...

    Authors: Jack L. Arbiser, Jo-David Fine, Dedee Murrell, Amy Paller, Susan Connors, Karen Keough, Elizabeth Marsh and Judah Folkman
    Citation: Molecular Medicine 1998 4:BF03401916
  26. Nitric oxide (NO) is cytostatic for proliferating cells, inhibits microbial growth, and down-regulates the synthesis of specific proteins. Studies were undertaken to determine the mechanism by which NO inhibit...

    Authors: Young-Myeong Kim, Kyonghee Son, Sun-Joo Hong, Angela Green, Jane-Jane Chen, Edith Tzeng, Christian Hierholzer and Timothy R. Billiar
    Citation: Molecular Medicine 1998 4:BF03401915
  27. The hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat cholestatic liver diseases. Interestingly, hepatocyte cell death from bile acid-induced toxicity...

    Authors: Cecilia M. P. Rodrigues, Guangsheng Fan, Phillip Y. Wong, Betsy T. Kren and Clifford J. Steer
    Citation: Molecular Medicine 1998 4:BF03401914
  28. Acute myeloid leukemia (AML) is a heterogeneous collection of leukemic disorders ranging from chemotherapy-sensitive subsets [inversion 16 and t(8;21)], which often can be cured with cytosine arabinoside alone...

    Authors: G. Deng, C. Lane, S. Kornblau, A. Goodacre, V. Snell, M. Andreeff and Albert B. Deisseroth
    Citation: Molecular Medicine 1998 4:BF03401913
  29. Several lines of evidence suggest that most of the early-onset forms of familial Alzheimer’s disease (FAD) are due to inherited mutations borne by a chromosome 14–encoded protein, presenilin 1 (PS1). This is l...

    Authors: Philippe Marambaud, Karine Ancolio, Elvira Lopez-Perez and Frédéric Checler
    Citation: Molecular Medicine 1998 4:BF03401912
  30. Acquired CI-inhibitor (C1-inh) deficiency is usually associated with the presence of circulating C1 -inh autoantibodies. These autoantibodies have been shown previously to bind to two synthetic peptides corres...

    Authors: Shiping He, Robert B. Sim, Keith Whaley and K. Austen
    Citation: Molecular Medicine 1998 4:BF03401735
  31. Attempts to optimize DNA vaccines in mice include using different routes of administration and different formulations. It may be more relevant to human use to carry such studies out in nonhuman primates. Here ...

    Authors: Robert A. Gramzinski, Cynthia L. Brazolot Millan, Nicanor Obaldia, Stephen L. Hoffman and Heather L. Davis
    Citation: Molecular Medicine 1998 4:BF03401734
  32. The molecular recognition theory (MRT) provides a conceptual framework that could explain the evolution of intermolecular and intramolecular interaction of peptides and proteins. As such, it predicts that bind...

    Authors: Nelson Ruiz-Opazo, Kenji Hirayama, Kaoru Akimoto and Victoria L. M. Herrera
    Citation: Molecular Medicine 1998 4:BF03401733
  33. Anthrax toxin, secreted by Bacillus anthracis, consists of protective antigen (PA) and either lethal factor (LF) or edema factor (EF). PA, the receptor-binding component of the toxin, translocates LF or EF into t...

    Authors: Mini Varughese, Angela Chi, Avelino V. Teixeira, Peter J. Nicholls, Jerry M. Keith and Stephen H. Leppla
    Citation: Molecular Medicine 1998 4:BF03401732
  34. A common genetic basis for IgA deficiency (IgAD) and common variable immunodeficiency (CVID) is suggested by their occurrence in members of the same family and the similarity of the underlying B cell different...

    Authors: Harry W. Schroeder Jr., Zeng-Bian Zhu, Ruth E. March, R. Duncan Campbell, Seth Mark Berney, Sergei A. Nedospasov, Regina L. Turetskaya, T. Prescott Atkinson, Rodney C. P. Go, Max D. Cooper and John E. Volanakis
    Citation: Molecular Medicine 1998 4:BF03401731
  35. Photodynamic therapy employs photosensitive agents such as porphyrins to treat a variety of tumors accessible to light-emitting probes. This approach capitalizes on the selective retention of porphyrins by can...

    Authors: Ajay Verma, Stephen L. Facchina, David J. Hirsch, Shi-Yu Song, Larry F. Dillahey, Jerry R. Williams and Solomon H. Snyder
    Citation: Molecular Medicine 1998 4:BF03401728
  36. The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accele...

    Authors: Adriana Ferreira, Lih-Shen Chin, Lian Li, Lorene M. Lanier, Kenneth S. Kosik and Paul Greengard
    Citation: Molecular Medicine 1998 4:BF03401726

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