Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 39 of 43

  1. The Btk (Bruton’s tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinas...

    Authors: Bratin K. Saha, Sherill K. Curtis, Larry B. Vogler and Mauno Vihinen

    Citation: Molecular Medicine 1997 3:BF03401694

    Content type: Original Articles

    Published on:

  2. Several plasmid DNA-based mammalian expression systems have recently been developed which make it possible to manipulate gene expression via the administration of exogenous agents. In order to extend the appli...

    Authors: Dirk Lindemann, Edward Patriquin, Sandy Feng and Richard C. Mulligan

    Citation: Molecular Medicine 1997 3:BF03401693

    Content type: Original Articles

    Published on:

  3. The synovial T cell infiltrate in rheumatoid arthritis (RA) is diverse but contains clonally expanded CD4+ populations. Recent reports have emphasized that RA patients have a tendency to develop CD4+ T cell oligo...

    Authors: Heike L. Rittner, Andreas Zettl, Michael C. Jendro, Peter Bartz-Bazzanella, Jörg J. Goronzy and Cornelia M. Weyand

    Citation: Molecular Medicine 1997 3:BF03401692

    Content type: Original Articles

    Published on:

  4. Cystic fibrosis (CF) is characterized by pancreatic destruction following the gradual obstruction of small pancreatic ducts, from the mid-trimester of gestation onwards. To date, the material causing the obstr...

    Authors: Golm J. Reid, Karen Hyde, Samuel B. Ho, Ann Harris and D. Weatherall

    Citation: Molecular Medicine 1997 3:BF03401687

    Content type: OriginalPaper

    Published on:

  5. The 845A(C282Y) mutation in the HLA-H gene accounts for most cases of hereditary hemochromatosis in patients who are of European origin. Some lack this mutation, however, and it is not present in Asian patients. ...

    Authors: Ernest Beutler, Carol West and Terri Gelbart

    Citation: Molecular Medicine 1997 3:BF03401686

    Content type: OriginalPaper

    Published on:

  6. A correct balance between protease and inhibitor activity is critical in the maintenance of homoeostasis; excessive activation of enzyme pathways is frequently associated with inflammatory disorders. Plasmin i...

    Authors: Eleanor M. Wallace, Stephen J. Perkins, Robert B. Sim, Anthony C. Willis, Con Feighery and John Jackson

    Citation: Molecular Medicine 1997 3:BF03401685

    Content type: OriginalPaper

    Published on:

  7. Mutations of the murine limb deformity (ld) locus are responsible for a pleiotropic phenotype of completely penetrant limb malformations and incompletely penetrant renal agenesis and/or dysgenesis. The ld locus e...

    Authors: Anthony Wynshaw-Boris, Gabriella Ryan, Chu-Xia Deng, David C. Chan, Laurie Jackson-Grusby, Denise Larson, Judy H. Dunmore and Philip Leder

    Citation: Molecular Medicine 1997 3:BF03401684

    Content type: OriginalPaper

    Published on:

  8. MHC class I molecule-restricted cytotoxic T-lymphocyte (CTL) responses are induced following either intramuscular (i.m.) injection of a DNA plasmid encoding influenza virus nucleoprotein (NP) or transplantatio...

    Authors: Tong-Ming Fu, Jeffrey B. Ulmer, Michael J. Caulfield, R. Randall Deck, Arthur Friedman, Su Wang, Xu Liu, John J. Donnelly, Margaret A. Liu and H. Wigzell

    Citation: Molecular Medicine 1997 3:BF03401683

    Content type: Original Articles

    Published on:

  9. Replication of HIV-1 in human T lymphocytes requires the activation of host cellular proteins. This study identifies p38 mitogen-activated protein kinase (MAPK) as one such kinase necessary for HIV-1 replicati...

    Authors: Pamela S. Cohen, Helena Schmidtmayerova, Jameel Dennis, Larisa Dubrovsky, Barbara Sherry, Haichao Wang, Michael Bukrinsky and Kevin J. Tracey

    Citation: Molecular Medicine 1997 3:BF03401812

    Content type: Original Articles

    Published on:

  10. AIDS-associated Kaposi’s sarcoma (AIDS-KS) represents one of the most common malignancies associated with human immunodeficiency virus infection. To target effective therapeutic agents to AIDS-KS, we have iden...

    Authors: Syed R. Husain, Parkash Gill, Robert J. Kreitman, Ira Pastan and Raj K. Puri

    Citation: Molecular Medicine 1997 3:BF03401811

    Content type: Original Articles

    Published on:

  11. The production of nitric oxide by type II inducible nitric oxide synthase (type II NOS) gene is controlled at least in part by transcriptional activation. Although the murine and human type II NOS genes share ...

    Authors: Sergei V. Spitsin, John L. Farber, Michael Bertovich, Gisela Moehren, Hilary Koprowski and Frank H. Michaels

    Citation: Molecular Medicine 1997 3:BF03401810

    Content type: Original Articles

    Published on:

  12. Resistance to thyroid hormone (RTH) is a syndrome characterized by refractoriness of the pituitary and/or peripheral tissues to the action of thyroid hormone. Mutations in the thyroid hormone receptor β (TRβ) gen...

    Authors: Rosemary Wong, Vyacheslav V. Vasilyev, Yuan-Tsang Ting, David I. Kutler, Mark C. Willingham, Bruce D. Weintraub and Sheue-yann Cheng

    Citation: Molecular Medicine 1997 3:BF03401809

    Content type: Original Articles

    Published on:

  13. The overexpression or amplification of tumor suppressor and proto-oncogenes are important factors in the progression of breast cancer. Recent attention has focused on the cyclin genes, whose involvement in sig...

    Authors: G. Wani, I. Noyes, G. E. Milo and S. M. D’Ambrosio

    Citation: Molecular Medicine 1997 3:BF03401680

    Content type: Original Articles

    Published on:

  14. Reactive arthritis (ReA) can develop as a consequence of a bacterial infection with organisms such as Chlamydia trachomata, Shigella flexneri, or Yersinia enterocolitica. Although the mechanism underlying the ind...

    Authors: Anja E. Schröder, Jochen Sieper and Claudia Berek

    Citation: Molecular Medicine 1997 3:BF03401679

    Content type: Original Articles

    Published on:

  15. Based on the hypothesis that IgGs are potent tolerogens and that immature lymphohematopoietic antigen-presenting cells (APC), and even mature peripheral B cells, may be effective APC for tolerance induction, w...

    Authors: Elias T. Zambidis, Anupama Kurup and David W. Scott

    Citation: Molecular Medicine 1997 3:BF03401674

    Content type: Original Articles

    Published on:

  16. Amyloid β-protein (Aβ), the major constituent of amyloid deposits found in Alzheimer’s disease, is derived from the β-amyloid precursor protein (βPP). Constitutive proteolysis by α-secretase and secretion of solu...

    Authors: Edward H. Koo and P. Greengard

    Citation: Molecular Medicine 1997 3:BF03401673

    Content type: Original Articles

    Published on:

  17. Although γδ T cells are a major component of the human intestinal mucosa, it is not clear what role they play in mucosal immunity or if they are involved in the disease process of inflammatory bowel disease (IBD)...

    Authors: Laila D. McVay, Baiqing Li, Renée Biancaniello, Mary Anne Creighton, Dale Bachwich, Gary Lichtenstein, John L. Rombeau and Simon R. Carding

    Citation: Molecular Medicine 1997 3:BF03401672

    Content type: Original Articles

    Published on:

  18. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the α-galactosidase A (α-Gal A) gene located at Xq22.1. To determine the nature and frequency of the molecular le...

    Authors: Christine M. Eng, Grace A. Ashley, Tania S. Burgert, Annette L. Enriquez, Marcus D’Souza, Robert J. Desnick and E. Beutler

    Citation: Molecular Medicine 1997 3:BF03401671

    Content type: Original Articles

    Published on:

  19. We sought to identify novel islet-cell autoantigens to better understand the pathogenesis, prediction, and immunotherapy of type 1 diabetes.

    Authors: James LaGasse, Laura Jelinek, Shannon Sexson, Cathy Lofton-Day, John Breininger, Paul Sheppard, Wayne Kindsvogel and William A. Hagopian

    Citation: Molecular Medicine 1997 3:BF03401670

    Content type: Original Articles

    Published on:

  20. The so-called antikeratin antibodies and the antiperinuclear factor are the most specific serological markers of rheumatoid arthritis (RA). They were recently shown to be largely the same autoantibodies and to...

    Authors: Elisabeth Girbal-Neuhauser, Martine Montézin, Françoise Croute, Mireille Sebbag, Michel Simon, Jean-Jacques Durieux and Guy Serre

    Citation: Molecular Medicine 1997 3:BF03401806

    Content type: Original Articles

    Published on:

  21. Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that participates in the pathogenesis of endotoxemia and experimental crescentic glomerulonephritis. However, very little is kn...

    Authors: Hui Y. Lan, Niansheng Yang, Christine Metz, Wei Mu, Qing Song, David J. Nikolic-Paterson, Michael Bacher, Richard Bucala and Robert C. Atkins

    Citation: Molecular Medicine 1997 3:BF03401805

    Content type: Original Articles

    Published on:

  22. Laminin 5, an anchoring filament attachment protein within the lamina lucida of the basement membrane zone involved in the pathogenesis of junctional epidermolysis bullosa (JEB), consists of three polypeptide ...

    Authors: Leena Pulkkinen, John McGrath, Tomi Airenne, Heli Haakana, Karl Tryggvason, Sirpa Kivirikko, Guerrino Meneguzzi, Jean-Paul Ortonne, Angela M. Christiano and Jouni Uitto

    Citation: Molecular Medicine 1997 3:BF03401804

    Content type: Original Articles

    Published on:

  23. The cytoplasmic domain of the Alzheimer’s disease amyloid precursor protein (APP) is phosphorylated in vitro at Thr654 and Ser655, and both in vitro and in intact cells at Thr668 (numbering for APP695 isoform).

    Authors: Masaki Oishi, Angus C. Nairn, Andrew J. Czernik, Gloria S. Lim, Toshio Isohara, Samuel E. Gandy, Paul Greengard and Toshiharu Suzuki

    Citation: Molecular Medicine 1997 3:BF03401803

    Content type: Original Articles

    Published on:

  24. The HIV-1 matrix (MA) protein, p17, contains two subcellular localization signals that facilitate both nuclear import of the viral preintegration complex early during infection and virus particle assembly late...

    Authors: Reuven Levin, Abner M. Mhashilkar, Tatyana Dorfman, Anatoly Bukovsky, Christy Zani, Jessamyn Bagley, Jorma Hinkula, Mattias Niedrig, Jan Albert, Britta Wahren, Heinrich G. Göttlinger and Wayne A. Marasco

    Citation: Molecular Medicine 1997 3:BF03401802

    Content type: Original Articles

    Published on:

  25. Upon engagement of the T cell receptor for antigen, its associated CD3 proteins recruit signal transduction molecules, which in turn regulate T lymphocyte proliferation, apoptosis, and thymocyte development. B...

    Authors: Baoping Wang, Jian She, Mariolina Salio, Deborah Allen, Elizabeth Lacy, Nils Lonberg and Cox Terhorst

    Citation: Molecular Medicine 1997 3:BF03401669

    Content type: Original Articles

    Published on:

  26. Antiviral cellular immune responses may influence immunological homeostasis in HIV-infected persons. Recent data indicate that Vγ9/Vδ2 T lymphocytes display potent cytotoxic activities against human cells infecte...

    Authors: Marianne Wallace, Alexander M. Scharko, C. David Pauza, Paul Fisch, Koichi Imaoka, Shigetada Kawabata, Kohtaro Fujihashi, Hiroshi Kiyono, Yoshimasa Tanaka, Barry R. Bloom and Miroslav Malkovsky

    Citation: Molecular Medicine 1997 3:BF03401668

    Content type: Original Articles

    Published on:

  27. The human maspin gene encodes a protein in the serine proteinase inhibitor (serpin) family with tumor-suppressing functions in cell culture and in nude mice. In order to examine the role of maspin in an intact...

    Authors: Ming Zhang, Shijie Sheng, Nicolai Maass and Ruth Sager

    Citation: Molecular Medicine 1997 3:BF03401667

    Content type: Original Articles

    Published on:

  28. Tumor necrosis factor-α (TNF-α) is chronically elevated in the adipose tissue from obese humans and mice. This increase in TNF-α contributes to the insulin resistance, elevated plasminogen activator inhibitor-1 (...

    Authors: Fahumiya Samad, Koji Yamamoto, Manjula Pandey and David J. Loskutoff

    Citation: Molecular Medicine 1997 3:BF03401666

    Content type: Original Articles

    Published on:

  29. CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here as CCR5-2) was identified th...

    Authors: Peter A. Zimmerman, Alicia Buckler-White, Ghalib Alkhatib, Todd Spalding, Joseph Kubofcik, Christophe Combadiere, Drew Weissman, Oren Cohen, Andrea Rubbert, Gordon Lam, Mauro Vaccarezza, Paul E. Kennedy, V. Kumaraswami, Janis V. Giorgi, Roger Detels, Jay Hunter…

    Citation: Molecular Medicine 1997 3:BF03401665

    Content type: Original Articles

    Published on:

  30. CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds wi...

    Authors: William D. Foulkes, Tamar Y. Flanders, Pamela M. Pollock and Nicholas K. Hayward

    Citation: Molecular Medicine 1997 3:BF03401664

    Content type: Review

    Published on:

  31. Prion diseases belong to a group of neurodegenerative disorders affecting humans and animals. The human diseases indude kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and...

    Authors: Susanne Krasemann, Martin H. Groschup, Silke Harmeyer, Gerhard Hunsmann and Walter Bodemer

    Citation: Molecular Medicine 1996 2:BF03401656

    Content type: Original Articles

    Published on:

  32. In a majority of cases, autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations within a putative open reading frame of the PKD1 gene. The encoded protein, polycystin, is predicted to span ...

    Authors: Runolfur Palsson, Chander P. Sharma, Keetae Kim, Margaret McLaughlin, Dennis Brown and M. Amin Arnaout

    Citation: Molecular Medicine 1996 2:BF03401654

    Content type: Original Articles

    Published on:

Annual Journal Metrics

  • Speed
    43 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    128 days from submission to acceptance
    24 days from acceptance to publication


    Citation Impact
    6.354 - 2-year Impact Factor
    5.230 - 5-year Impact Factor

    Usage
    460,369 downloads
    204 Altmetric mentions