Articles

Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line

Vitamin D deficiency increases the risk of developing multiple sclerosis (MS) but it is unclear whether vitamin D supplementation improves the clinical course of MS, and there is uncertainty about the dose and...

Authors: Manuela Mengozzi, Andrew Hesketh, Giselda Bucca, Pietro Ghezzi and Colin P. Smith

microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway

Accumulating evidence has implicated the regulation of microRNAs (miRs) in ischemia stroke. The current study aimed to elucidate the role of microRNA-195 (miR-195) in neuronal apoptosis and brain plasticity in...

Authors: Lisha Chang, Wan Zhang, Songxin Shi, Yanbo Peng, Dali Wang, Li Zhang and Jiang Zhang

circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling

Glioma has the characteristics of high incidence and mortality, and is a common malignant tumor of the central nervous system. Circular RNAs (circRNAs) have been reported to play vital roles in progression of ...

Authors: Long-Wei Huo, Ya-Fei Wang, Xiao-Bin Bai, Hu-Lin Zheng and Mao-De Wang

Shikonin suppresses NEAT1 and Akt signaling in treating paclitaxel-resistant non-small cell of lung cancer

The development of paclitaxel-resistance led to the tumor relapse and treatment failure of non-small cell lung cancer. Shikonin has been demonstrated to show anti-cancer activity in many cancer types. The pres...

Authors: Farong Zang, Yuanquan Rao, Xinhai Zhu, Zhibing Wu and Hao Jiang

TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin α5 pathway

Tissue factor pathway inhibitor 2 (TFPI2) participates in carcinogenesis of various tumors, and is associated with poor survival of breast cancer patients. However, the effect and underlying mechanism of TFPI2...

Authors: Danyi Zhao, Jingjing Qiao, Hongmei He, Jincheng Song, Shanshan Zhao and Jing Yu

LncRNA HULC induces the progression of osteosarcoma by regulating the miR-372-3p/HMGB1 signalling axis

Osteosarcoma is a malignancy that normally affects children, adolescents, and young adults. Although accumulating evidence has demonstrated the importance of HULC in osteosarcoma, little is reported about its ...

Authors: Yong Li, Jing-Jing Liu, Jia-Hui Zhou, Rui Chen and Chao-Qun Cen

Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach

B cell receptor Immunoglobulin (BcR IG) repertoire of Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of quasi-identical BcR IG. These are observed in approximately 30% of patients, defin...

Authors: Monica Colombo, Davide Bagnara, Daniele Reverberi, Serena Matis, Martina Cardillo, Rosanna Massara, Luca Mastracci, Jean Louis Ravetti, Luca Agnelli, Antonino Neri, Michela Mazzocco, Margherita Squillario, Andrea Nicola Mazzarello, Giovanna Cutrona, Andreas Agathangelidis, Kostas Stamatopoulos…

Upregulation of the transcription factor TFAP2D is associated with aggressive tumor phenotype in prostate cancer lacking the TMPRSS2:ERG fusion

TFAP2D is a transcription factor important for modulating gene expression in embryogenesis. Its expression and prognostic role in prostate cancer has not been evaluated.

Authors: Christoph Fraune, Luisa Harms, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Katharina Möller, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Guido Sauter, Sören Weidemann, Patrick Lebok, David Dum…

Digital imaging-assisted quantification of H3K27me3 immunoexpression in luminal A/B-like, HER2-negative, invasive breast cancer predicts patient survival and risk of recurrence

Breast cancer (BC) is a major health concern and better understanding of its biology might improve treatment decisions and patient outcomes. Histone3 Lysine27 tri-methylation (H3K27me3) is a post-translational...

Authors: Mário Fontes-Sousa, João Lobo, Silvana Lobo, Sofia Salta, Maria Amorim, Paula Lopes, Luís Antunes, Susana Palma de Sousa, Rui Henrique and Carmen Jerónimo

D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1

D-allose was promising in the protection of ischemia/reperfusion (I/R) injury. We intended to investigate the function of D-allose in skin flap of rat followed by the injury of I/R and whether ERK signal pathw...

Authors: Jihui Ju, Ruixing Hou and Ping Zhang

The role of RICTOR amplification in targeted therapy and drug resistance

The emergence of tyrosine kinase inhibitors (TKIs) has changed the current treatment paradigm and achieved good results in recent decades. However, an increasing number of studies have indicated that the compl...

Authors: Deze Zhao, Man Jiang, Xiaochun Zhang and Helei Hou

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

The serine protease KLK12 belongs to the human fifteen-member family of kallikrein-related peptidases. Differential expression accompanied by either increased or decreased enzymatic activity has been linked to...

Authors: Weiwei Gong, Yueyang Liu, Sarah Preis, Xiaocong Geng, Agnes Petit-Courty, Marion Kiechle, Alexander Muckenhuber, Tobias Dreyer, Julia Dorn, Yves Courty and Viktor Magdolen

Expression of Concern to: Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)

Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine

Expression of concern to: High systematic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome

Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter, Daniel J. Antoine and Ulf Andersson

Expression of Concern to: The α7 nicotine acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

The Editors-in-Chief would like to alert readers that this article (Sitapara et al. 2014) is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the...

Authors: Ravikumar A. Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek S. Patel, Charles R. Ashby Jr, Samir Gorasiya, Huan Yang, Michelle Zur and Lin L. Mantell

Cardioprotective effects of genetically engineered cardiac stem cells by spheroid formation on ischemic cardiomyocytes

Sca-1+ cardiac stem cells and their limited proliferative potential were major limiting factors for use in various studies.

Authors: Han Saem Jeong, Chi-Yeon Park, Jong-Ho Kim, Hyung Joon Joo, Seung-Cheol Choi, Ji-Hyun Choi, I-Rang Lim, Jae Hyoung Park, Soon Jun Hong and Do-Sun Lim

Aspirin has a better effect on PIK3CA mutant colorectal cancer cells by PI3K/Akt/Raptor pathway

Aspirin, as a non-steroidal anti-inflammatory drug, can improve the survival rate of patients with colorectal cancer, while aspirin is effective in patients with PIK3CA mutant colorectal cancer (CRC). However,...

Authors: Zhihang Chen, Chun Wang, Hao Dong, Xing Wang, Feng Gao, Sen Zhang and Xiaolong Zhang

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

The Editors-in-Chief would like to alert readers that this article [1] is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Live...

Authors: Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty and B. Kevin Park

NGF (−198C > T, Ala35Val) and p75^NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

Neural growth factor (NGF) is a neurotrophin that can interact with the p75^NTR receptor and initiate a cascade of reactions that determines cell survival or death, and both are associated with the physiology of l...

Authors: Leonn Mendes Soares Pereira, Ednelza da Silva Graça Amoras, Simone Regina Souza da Silva Conde, Sâmia Demachki, Eduardo José Melo dos Santos, Sandra Souza Lima, Ricardo Ishak and Antonio Carlos Rosário Vallinoto

The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population

Genetic variants play a critical role in the development of breast cancer. This investigation aimed to explore the association between CASC16 polymorphisms and breast cancer susceptibility.

Authors: Xiaoxiao Zuo, Huanhuan Wang, Yin Mi, Yue Zhang, Xiaofei Wang, Ya Yang and Suna Zhai

The mitohormetic response as part of the cytoprotection mechanism of berberine

It was well-known that Berberine, a major bioactive compound extracted from natural plants Coptis chinensis, has anti-diabetic effects for decades in china. Other types of pharmacological activities, such as anti...

Authors: Xiaofei Zhu, Yihui Wei, Beibei Yang, Xiaoxiao Yin and Xiaofang Guo

Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious pulmonary diseases that contain common and unique characteristics. Therefore, the identification ...

Authors: Mazaher Maghsoudloo, Sadegh Azimzadeh Jamalkandi, Ali Najafi and Ali Masoudi-Nejad

Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis

Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of biochemis...

Authors: Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Dimitrios P. Bogdanos, Piotr Milkiewicz and Malgorzata Milkiewicz

Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study

Previous studies have found ischemic stroke is associated with atrial fibrillation. However, the causal association between ischemic stroke and atrial fibrillation is not clear. Furthermore, the network relati...

Authors: Lei Hou, Mingqing Xu, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Lu Liu, Yunxia Li, Tonghui Yuan, Wenchao Li, Hongkai Li and Fuzhong Xue

Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis

The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patt...

Authors: Zachary Mostel, Abraham Perl, Matthew Marck, Syed F. Mehdi, Barbara Lowell, Sagar Bathija, Ramchandani Santosh, Valentin A. Pavlov, Sangeeta S. Chavan and Jesse Roth

HMGB1 concentration measurements in trauma patients: assessment of pre-analytical conditions and sample material

HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, d...

Authors: William Ottestad, Ingrid N. Rognes, Erlend Skaga, Cassandra Frisvoll, Guttorm Haraldsen, Torsten Eken and Peter Lundbäck

Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape

The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in t...

Authors: Reham M. Milhem and Bassam R. Ali

Inhibition of microRNA-29a alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice via upregulation of GAB1

The main features of bronchopulmonary dysplasia (BPD) are alveolar simplification, pulmonary growth arrest, and abnormal lung function. Multiple studies have highlighted microRNA-29 (miR-29) as a potential bio...

Authors: Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou and Hanmin Liu

Role of 5-HT₇ receptors in the immune system in health and disease

In mammalians, serotonin (5-HT) has critical roles in the central nervous system (CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority of serotonin is produced by intes...

Authors: Alejandro Quintero-Villegas and Sergio Iván Valdés-Ferrer

Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins

Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...

Authors: Lourdes Valdés-Sánchez, Sofia M. Calado, Berta de la Cerda, Ana Aramburu, Ana Belén García-Delgado, Simone Massalini, Adoración Montero-Sánchez, Vaibhav Bhatia, Eduardo Rodríguez-Bocanegra, Andrea Diez-Lloret, Daniel Rodríguez-Martínez, Christina Chakarova, Shom S. Bhattacharya and Francisco J. Díaz-Corrales

The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review

The incidence and mortality of strokes have increased over the past three decades in China. Ischemic strokes can cause a sequence of detrimental events in patients, including increased permeability and dysfunc...

Authors: Zili Feng, Qian Sun, Wang Chen, Yu Bai, Daihua Hu and Xin Xie

Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation

There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act s...

Authors: Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi and Toshiro Okazaki

Long non-coding RNA MCM3AP-AS1 promotes growth and migration through modulating FOXK1 by sponging miR-138-5p in pancreatic cancer

Pancreatic cancer (PC) is a type of malignant gastrointestinal tumor. Long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to stimulate proliferation, migration and invasion in several typ...

Authors: Ming Yang, Shijuan Sun, Yao Guo, Junjie Qin and Guangming Liu

Edaravone reduces oxidative stress and intestinal cell apoptosis after burn through up-regulating miR-320 expression

Intestinal mucosa barrier dysfunction after burn injury is an important factor for causing mortality of burn patients. The current study established a burn model in rats and used a free radical scavenger edara...

Authors: Jiaxiang Ke, Xi Bian, Hu Liu, Bei Li and Ran Huo

Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment

Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adv...

Authors: Shimin An, Nimra Gilani, Yuan Huang, Adam Muncan, Youhua Zhang, Yi-Da Tang, A. Martin Gerdes and Kaie Ojamaa

Recombinant human milk fat globule-EGF factor VIII (rhMFG-E8) as a therapy for sepsis after acute exposure to alcohol

Alcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth factor-factor VIII (MFG-E8), a glycoprotein essential for optimal efferocytos...

Authors: Wayne W. Chaung, Max Brenner, Hao-Ting Yen, Mahendar L. Ochani, Asha Jacob and Ping Wang

Comparison of blood lipid profile/thyroid function markers between unipolar and bipolar depressed patients and in depressed patients with anhedonia or suicidal thoughts

This study aimed to investigate the differences in the serum levels of glucose, lipid, and thyroid function markers between unipolar and bipolar depressed patients, as well as the effect of anhedonia and suici...

Authors: Meilei Su, Enze Li, Chong Tang, Yongzhi Zhao, Ruqing Liu and Keming Gao

Circulating tumor cells: a valuable marker of poor prognosis for advanced nasopharyngeal carcinoma

To evaluate the prognostic value of circulating tumor cells (CTCs) in nasopharyngeal carcinoma (NPC).

Authors: Guoping Ou, Shan Xing, Jianpei Li, Lin Zhang and Shulin Chen

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulat...

Authors: Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria and Nhan L. Tran

Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid

To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.

Authors: Meruyert Massabayeva, Nailya Chaizhunusova, Nurlan Aukenov, Tolkyn Bulegenov, Bakytbek Apsalikov, Aigerim Shapihanova and Yersin Zhunussov

Integrated transcriptomic analysis reveals hub genes involved in diagnosis and prognosis of pancreatic cancer

The hunt for the molecular markers with specificity and sensitivity has been a hot area for the tumor treatment. Due to the poor diagnosis and prognosis of pancreatic cancer (PC), the excision rate is often lo...

Authors: Yang-Yang Zhou, Li-Ping Chen, Yi Zhang, Sun-Kuan Hu, Zhao-Jun Dong, Ming Wu, Qiu-Xiang Chen, Zhi-Zhi Zhuang and Xiao-Jing Du

An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes rel...

Authors: Wai Hoong Chang and Alvina G. Lai

Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2

Club Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-in...

Authors: Baolin Xu, Andrea Janicova, Jan Tilmann Vollrath, Philipp Störmann, Lukas Martin, Ingo Marzi, Sebastian Wutzler, Frank Hildebrand, Sabrina Ehnert and Borna Relja

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer

Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/...

Authors: Qicai Liu, Ling Guo, Sheng Zhang, Jingwen Wang, Xinhua Lin and Feng Gao

Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis

The protective effect of melatonin against bone metabolism imbalance in osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this study was to explore the role of melatonin in b...

Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang

Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue

HER2 is considered as one of the most important, predictive biomarkers in oncology. The diagnosis of HER2 positive cancer types such as breast- and gastric cancer is usually based on immunohistochemical HER2 s...

Authors: Diana B. Peckys, Daniela Hirsch, Timo Gaiser and Niels de Jonge

Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats

Peritoneal fibrosis (PF) represents a long-term complication of peritoneal dialysis (PD), affecting peritoneal membrane (PM) integrity and function. Understanding the mechanisms underlying PF development in an...

Authors: Filipe M. O. Silva, Elerson C. Costalonga, Cleonice Silva, Ana C. O. Carreira, Samirah A. Gomes, Mari C. Sogayar, Camilla Fanelli and Irene L. Noronha

Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. ...

Authors: Takashi Tani, Ken Okamoto, Megumi Fujiwara, Akira Katayama and Shuichi Tsuruoka

The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation

Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammato...

Authors: Marie Hilderman, Abdul Rashid Qureshi, Farhad Abtahi, Nils Witt, Christina Jägren, Joakim Olbers, Martin Delle, Kaj Lindecrantz and Annette Bruchfeld

High co-expression of TNF-α and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia

Early distinction between refractory M. pneumoniae pneumonia (RMPP) and non-RMPP (NRMPP) is still difficult. The community-acquired respiratory distress syndrome (CARDS) toxin can induce inflammatory and histopat...

Authors: Gang Li, Liping Fan, Yuqing Wang, Li Huang, Meijuan Wang, Canhong Zhu, Chuangli Hao, Wei Ji, Hansi Liang, Yongdong Yan and Zhengrong Chen