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  1. Tumor necrosis factor α (TNF-α) is often considered the main proinflammatory cytokine induced by lipopolysaccharide (LPS) and consequently the critical mediator of the lethality associated with septic shock.

    Authors: Franck Amiot, Catherine Fitting, Kevin J. Tracey, Jean-Marc Cavaillon and François Dautry
    Citation: Molecular Medicine 1997 3:BF03401722
    Content type: Original Articles Published on:

  3. Substantial evidence has suggested that T cells play an important role in antitumor immunity. T cells with cytotoxic activity against tumors have been isolated from in vitro culture of tumor-infiltrated lympho...

    Authors: Koichi Ito, James Fetten, Houman Khalili, Steven Hajdu, Erna Busch, Robert Pergolizzi, Vincent Vinciguerra and Ming-der Y. Chang
    Citation: Molecular Medicine 1997 3:BF03401720
    Content type: Original Articles Published on:

  4. GLI is an oncodevelopmental gene in the vertebrate hedgehog/patched signaling pathway that is spatiotemporally regulated during development and is amplified in a subset of human cancers. GLI is the prototype for ...

    Authors: Jian Tao Yang, Cheng Zheng Liu, Elisabeth H. Villavicencio, Joon Won Yoon, David Walterhouse and Philip M. Iannaccone
    Citation: Molecular Medicine 1997 3:BF03401719
    Content type: Original Articles Published on:

  5. Vectors based on herpes simplex virus type 1 (HSV-1) can efficiently transduce hepatocytes in the mouse liver, and vector genomes can persist for at least 2 months. However, 24 hr after gene transfer, the numb...

    Authors: Cornel Fraefel, David R. Jacoby, Christopher Lage, Harold Hilderbrand, Janice Y. Chou, Fred W. Alt, Xandra O. Breakefield and Joseph A. Majzoub
    Citation: Molecular Medicine 1997 3:BF03401718
    Content type: Original Articles Published on:

  9. Cerebral ischemia induces a rapid and dramatic up-regulation of tumor necrosis factor (TNF) protein and mRNA, but the cellular sources of TNF in the ischemic brain have not been defined. The diverse activities...

    Authors: Galina I. Botchkina, Malcolm E. Meistrell III, Inna L. Botchkina and Kevin J. Tracey
    Citation: Molecular Medicine 1997 3:BF03401714
    Content type: Original Articles Published on:

  10. Excitotoxicity and excess generation of nitric oxide (NO) are believed to be fundamental mechanisms in many acute and chronic neurodegenerative disorders. Disturbance of Ca2+ homeostasis and protein nitration/nit...

    Authors: Marcel Leist, Christiane Volbracht, Simone Kühnle, Eugenio Fava, Elisa Ferrando-May and Pierluigi Nicotera
    Citation: Molecular Medicine 1997 3:BF03401713
    Content type: Original Articles Published on:

  11. DNA modified by advanced glycation endproducts (AGEs) undergoes a high frequency of insertional mutagenesis. In mouse lymphoid cells, these mutations are due in part to the transposition of host genomic elemen...

    Authors: Tatiana Pushkarsky, Linda Rourke, Lori A. Spiegel, Michael F. Seldin and Richard Bucala
    Citation: Molecular Medicine 1997 3:BF03401712
    Content type: Original Articles Published on:

  12. Brucelosis is a severe acute febrile disease caused by bacteria of the genus Brucella. Its current diagnosis is based on clinical observations that may be complemented by serology and microbiological culture test...

    Authors: Ana M. Sifuentes-Rincón, Agnès Revol and Hugo A. Barrera-Saldaña
    Citation: Molecular Medicine 1997 3:BF03401711
    Content type: Original Articles Published on:

  13. The adoptive transfer of cytotoxic T lymphocytes (CTLs) derived from tumor-infiltrating lymphocytes (TIL) along with interleukin 2 (IL-2) into autologous patients with cancer resulted in the objective regressi...

    Authors: Rong-Fu Wang
    Citation: Molecular Medicine 1997 3:BF03401710
    Content type: Review Published on:

  15. In Alzheimer’s disease (AD), the main histological lesion is a proteinaceous deposit, the senile plaque, which is mainly composed of a peptide called Aβ. The aggregation process is thought to occur through enhanc...

    Authors: Hélène Barelli, Anthony Lebeau, Jean Vizzavona, Pia Delaere, Nathalie Chevallier, Cyril Drouot, Philippe Marambaud, Karine Ancolio, Joseph D. Buxbaum, Olga Khorkova, Jeff Heroux, Sudhir Sahasrabudhe, Jean Martinez, Jean-Marie Warter, Michel Mohr and Frédéric Checler
    Citation: Molecular Medicine 1997 3:BF03401708
    Content type: Original Articles Published on:

  16. IgE/allergen-dependent activation of skin mast cells is involved in acute urticaria and leads to their EL-4 release. Previously we have demonstrated in vitro the induction of the low-affinity receptor for IgE ...

    Authors: Pierre-André Bécherel, Olivier Chosidow, Liliane Le Goff, Camille Francès, Patrice Debré, M. Djavad Mossalayi and Michel Arock
    Citation: Molecular Medicine 1997 3:BF03401707
    Content type: Original Articles Published on:

  17. Raf-1, a cytoplasmic serine/threonine protein kinase, plays an important role in mitogen- and damage-responsive cellular signal transduction pathways. Consistent with this notion is the fact that constitutive ...

    Authors: Sonal Patel, Fuh-Han Wang, Theresa L. Whiteside and Usha Kasid
    Citation: Molecular Medicine 1997 3:BF03401706
    Content type: Original Articles Published on:

  18. The agouti yellow mouse shows adult onset of moderate obesity and diabetes. A depressed basal lipolytic rate in adipocytes or a decreased adrenergic tone arising from antagonizing α-melanocyte-stimulating hormone...

    Authors: Yvon C. Chagnon, Wen-Ji Chen, Louis Pérusse, Monique Chagnon, André Nadeau, William O. Wilkison and Claude Bouchard
    Citation: Molecular Medicine 1997 3:BF03401705
    Content type: Original Articles Published on:

  19. Spontaneous animal models of human autoimmune diseases provide the means to study the very first pathogenetic events, which is not possible in their human counterparts. This is particularly true for connective...

    Authors: Michael J. Ausserlechner, Roswitha Sgonc, Hermann Dietrich and Georg Wick
    Citation: Molecular Medicine 1997 3:BF03401704
    Content type: Original Articles Published on:

  22. Advanced glycation endproducts (AGEs) are implicated in the pathogenesis of atherosclerotic vascular disease of diabetic and nondiabetic etiology. Recent research suggests that advanced glycation of ApoB contr...

    Authors: Alan William Stitt, Cijiang He, Steven Friedman, Larry Scher, Peter Rossi, Larry Ong, Hank Founds, Yong Ming Li, Richard Bucala and Helen Vlassara
    Citation: Molecular Medicine 1997 3:BF03401819
    Content type: Original Articles Published on:

  23. Mice with targeted disruption of the gene for the neuronal isoform of nitric oxide synthase (nNOS) display exaggerated aggression. Behavioral studies of mice with targeted gene deletions suffer from the critic...

    Authors: Gregory E. Demas, Mikael J. L. Eliasson, Ted M. Dawson, Valina L. Dawson, Lance J. Kriegsfeld, Randy J. Nelson and Solomon H. Snyder
    Citation: Molecular Medicine 1997 3:BF03401818
    Content type: Original Articles Published on:

  24. Cardiopulmonary bypass (CPB) and hypothermic circulatory arrest (HCA) are important components of congenital cardiac surgery. Ischemia/reperfusion injury and inflammatory cascade activation result in endotheli...

    Authors: Sarah Tabbutt, David P. Nelson, Nina Tsai, Takuya Miura, Paul R. Hickey, John E. Mayer and Ellis J. Neufeld
    Citation: Molecular Medicine 1997 3:BF03401817
    Content type: Original Articles Published on:

  25. Balloon injury of the arterial wall induces increased vascular smooth cell proliferation, enhanced elastic recoil, and abnormalities in thrombosis, each of which contribute to regrowth of intima and the lesion...

    Authors: Dominique Stephan, Hong San, Zhi-yong Yang, David Gordon, Susan Goelz, Gary J. Nabel and Elizabeth G. Nabel
    Citation: Molecular Medicine 1997 3:BF03401816
    Content type: Original Articles Published on:

  26. The sickle-cell trait protects against severe Plasmodium falciparum malaria and reduces susceptibility to mild malaria but does not prevent infection. The exact mechanism of this protection remains unclear. We ha...

    Authors: Francine Ntoumi, Christophe Rogier, Alioune Dieye, Jean-François Trape, Pascal Millet and Odile Mercereau-Puijalon
    Citation: Molecular Medicine 1997 3:BF03401815
    Content type: Original Articles Published on:

  29. HIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-level plasma viremia is a lik...

    Authors: Milan Fiala, David J. Looney, Monique Stins, Dennis D. Way, Ling Zhang, Xiaohu Gan, Francesco Chiappelli, Erik S. Schweitzer, Paul Shapshak, Martin Weinand, Michael C. Graves, Marlys Witte and Kwang Sik Kim
    Citation: Molecular Medicine 1997 3:BF03401701
    Content type: Original Articles Published on:

  30. Human natural antibodies have been found that owe their candidacidal action to the mimicry of a yeast killer toxin produced by the yeast Pichia anomala (PaKT). Candidacidal human natural antibodies (KTAb) are eli...

    Authors: Nathalie Séguy, Jean-Charles Cailliez, Philippe Delcourt, Stefania Conti, Daniel Camus, Eduardo Dei-Cas and Luciano Polonelli
    Citation: Molecular Medicine 1997 3:BF03401700
    Content type: Original Articles Published on:

  31. Giant cell arteritis (GCA) is a systemic vasculitis that preferentially targets medium-sized and large arteries. The etiopathogenesis of the syndrome is not known, and because of the paucity of information con...

    Authors: Alexander Brack, Annette Geisler, Victor M. Martinez-Taboada, Brian R. Younge, Jörg J. Goronzy and Cornelia M. Weyand
    Citation: Molecular Medicine 1997 3:BF03401699
    Content type: Original Articles Published on:

  32. The pleiotropic cytokine interleukin-6 mediates its multiple effects at the cell level through a multimeric receptor consisting of a binding protein (gp80) and a signal transducer (gp130). A soluble form of gp...

    Authors: Vincent Thibault, Bernard Terlain, Frank L. Graham and Jack Gauldie
    Citation: Molecular Medicine 1997 3:BF03401698
    Content type: Original Articles Published on:

  33. Chondroitin-4-sulfate (CSA) was recently described as a Plasmodium falciparum cytoadherence receptor present on Saimiri brain microvascular and human lung endothelial cells.

    Authors: Bruno Pouvelle, Pascal Meyer, Claire Robert, Laurence Bardel and Jürg Gysin
    Citation: Molecular Medicine 1997 3:BF03401697
    Content type: Original Articles Published on:

  36. The Btk (Bruton’s tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinas...

    Authors: Bratin K. Saha, Sherill K. Curtis, Larry B. Vogler and Mauno Vihinen
    Citation: Molecular Medicine 1997 3:BF03401694
    Content type: Original Articles Published on:

  37. Several plasmid DNA-based mammalian expression systems have recently been developed which make it possible to manipulate gene expression via the administration of exogenous agents. In order to extend the appli...

    Authors: Dirk Lindemann, Edward Patriquin, Sandy Feng and Richard C. Mulligan
    Citation: Molecular Medicine 1997 3:BF03401693
    Content type: Original Articles Published on:

  38. The synovial T cell infiltrate in rheumatoid arthritis (RA) is diverse but contains clonally expanded CD4+ populations. Recent reports have emphasized that RA patients have a tendency to develop CD4+ T cell oligo...

    Authors: Heike L. Rittner, Andreas Zettl, Michael C. Jendro, Peter Bartz-Bazzanella, Jörg J. Goronzy and Cornelia M. Weyand
    Citation: Molecular Medicine 1997 3:BF03401692
    Content type: Original Articles Published on:

  39. DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and positively regulates the exp...

    Authors: Lin Wu and Arnold J. Levine
    Citation: Molecular Medicine 1997 3:BF03401691
    Content type: Original Articles Published on:

  43. Cystic fibrosis (CF) is characterized by pancreatic destruction following the gradual obstruction of small pancreatic ducts, from the mid-trimester of gestation onwards. To date, the material causing the obstr...

    Authors: Golm J. Reid, Karen Hyde, Samuel B. Ho, Ann Harris and D. Weatherall
    Citation: Molecular Medicine 1997 3:BF03401687
    Content type: OriginalPaper Published on:

  44. The 845A(C282Y) mutation in the HLA-H gene accounts for most cases of hereditary hemochromatosis in patients who are of European origin. Some lack this mutation, however, and it is not present in Asian patients. ...

    Authors: Ernest Beutler, Carol West and Terri Gelbart
    Citation: Molecular Medicine 1997 3:BF03401686
    Content type: OriginalPaper Published on:

  45. A correct balance between protease and inhibitor activity is critical in the maintenance of homoeostasis; excessive activation of enzyme pathways is frequently associated with inflammatory disorders. Plasmin i...

    Authors: Eleanor M. Wallace, Stephen J. Perkins, Robert B. Sim, Anthony C. Willis, Con Feighery and John Jackson
    Citation: Molecular Medicine 1997 3:BF03401685
    Content type: OriginalPaper Published on:

  46. Mutations of the murine limb deformity (ld) locus are responsible for a pleiotropic phenotype of completely penetrant limb malformations and incompletely penetrant renal agenesis and/or dysgenesis. The ld locus e...

    Authors: Anthony Wynshaw-Boris, Gabriella Ryan, Chu-Xia Deng, David C. Chan, Laurie Jackson-Grusby, Denise Larson, Judy H. Dunmore and Philip Leder
    Citation: Molecular Medicine 1997 3:BF03401684
    Content type: OriginalPaper Published on:

  47. MHC class I molecule-restricted cytotoxic T-lymphocyte (CTL) responses are induced following either intramuscular (i.m.) injection of a DNA plasmid encoding influenza virus nucleoprotein (NP) or transplantatio...

    Authors: Tong-Ming Fu, Jeffrey B. Ulmer, Michael J. Caulfield, R. Randall Deck, Arthur Friedman, Su Wang, Xu Liu, John J. Donnelly, Margaret A. Liu and H. Wigzell
    Citation: Molecular Medicine 1997 3:BF03401683
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658