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Page 42 of 44

  1. Mice with inactivated tumor necrosis factor (TNF) and lymphotoxin α (LTα) genes have profound abnormalities of the immune system including lymphocytosis, lack of lymph nodes, undifferentiated spleen, hypoimmunogl...

    Authors: Matthias Müller, Hans-Pietro Eugster, Michel Le Hir, Alexander Shakhov, Franco Di Padova, Claudine Maurer, Valerie F. J. Quesniaux and Bernhard Ryffel
    Citation: Molecular Medicine 1996 2:BF03401621
  2. Human falciparum malaria, caused by the intracellular protozoa Plasmodium falciparum, results in 1–2 million deaths per year. P. falciparum digests host erythrocyte hemoglobin within its food vacuole, resulting i...

    Authors: James A. Martiney, Anthony Cerami and Andrew F. G. Slater
    Citation: Molecular Medicine 1996 2:BF03401620
  3. Nitric oxide has a wide variety of homeostatic and pathological effects. Control of the production of nitric oxide by the inducible form of the enzyme resides in the 5′ promoter region of the gene. Although co...

    Authors: Sergei V. Spitsin, Hilary Koprowski and Frank H. Michaels
    Citation: Molecular Medicine 1996 2:BF03401619
  4. Nitric oxide (NO) has been shown to decrease myointimal hyperplasia in injured blood vessels. We hypothesize inducible NO synthase (iNOS) gene transfer even at low efficiency will provide adequate local NO pro...

    Authors: Edith Tzeng, Larry L. Shears II, Paul D. Robbins, Bruce R. Pitt, David A. Geller, Simon C. Watkins, Richard L. Simmons and Timothy R. Billiar
    Citation: Molecular Medicine 1996 2:BF03401618
  5. Parathyroid hormone-related protein (PTHrP) is a ubiquitous and highly conserved vasoactive peptide whose role and regulation in normal physiology remain an enigma. Recently, we demonstrated that low-dose endo...

    Authors: Janet L. Funk, Arthur H. Moser, Gordon J. Strewler, Kenneth R. Feingold and Carl Grünfeld
    Citation: Molecular Medicine 1996 2:BF03401617
  6. Protein tyrosine kinases play an imporH-RYK, an Unusual Receptor Kinase: Isolation and Analysis of Expression in Ovarian Cancertant role in cellular metabolism as key components of signal transduction pathways...

    Authors: Xiao C. Wang, Roy Katso, Robin Butler, Andrew M. Hanby, Richard Poulsom, Tania Jones, Denise Sheer and Trivadi S. Ganesan
    Citation: Molecular Medicine 1996 2:BF03401616
  7. An important issue in autoimmune diseases mediated by T cells, such as experimental allergic encephalomyelitis (EAE), is the affinity of the disease-inducing determinants for MHC class II proteins. Tolerance, ...

    Authors: Lars Fugger, James Liang, Anand Gautam, Jonathan B. Rothbard and Hugh O. McDevitt
    Citation: Molecular Medicine 1996 2:BF03401615
  8. The apolipoprotein E (apoE) type ε4 isoform specifies increased cerebral and cerebrovascular accumulation of amyloid-β protein (Aβ) and contributes to the genetic susceptibility underlying a large proportion (~60...

    Authors: Zhongmin Zhou, Jonathan D. Smith, Paul Greengard and Sam Gandy
    Citation: Molecular Medicine 1996 2:BF03401614
  9. Recent studies of melanin biosynthesis have uncovered an unusual enzymatic activity which converts the non-naturally occurring D-isomer of 2-carboxy-2,3-dihydroindole-5,6-quinone (dopachrome) into 5,6-dihydroxyin...

    Authors: Evald Rosengren, Richard Bucala, Pierre Åman, Lars Jacobsson, Gerd Odh, Christine N. Metz and Hans Rorsman
    Citation: Molecular Medicine 1996 2:BF03402210
  10. The main difficulty in providing effective treatment of patients with cancer is distinguishing between tumor and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities (suc...

    Authors: B. García-Hernández and I. Sánchez-García
    Citation: Molecular Medicine 1996 2:BF03402208
  11. Activation of either the 55-kD tumor necrosis factor receptor (TNF-R1) or CD95 (Fas/Apo-1) causes apoptosis of cells and liver failure in mice, and has been associated with human liver disorders. The aim of th...

    Authors: Marcel Leist, Florian Gantner, Gerald Künstle, Ines Bohlinger, Gisa Tiegs, Horst Bluethmann and Albrecht Wendel
    Citation: Molecular Medicine 1996 2:BF03402207
  12. The gene encoding the hepatotrophic factor Augmenter of Liver Regeneration (ALR) has recently been cloned in the rat. The availability of the mouse form of ALR would allow the analysis of the role of this fact...

    Authors: Roberto Giorda, Michio Hagiya, Tatsuya Seki, Manabu Shimonishi, Harumi Sakai, James Michaelson, Antonio Francavilla, Thomas E. Starzl and Massimo Trucco
    Citation: Molecular Medicine 1996 2:BF03402206
  13. Csx/Nkx2.5, a murine nonclustered homeobox gene expressed primarily in the heart, has significant sequence similarity to the Drosophila tinman gene. Tinman is essential for heart and gut formation in Drosophila. ...

    Authors: David Turbay, Stephanie Burns Wechsler, Kristina McQuate Blanchard and Seigo Izumo
    Citation: Molecular Medicine 1996 2:BF03402205
  14. Several neurological disorders have recently been explained through the discovery of expanded DNA repeat sequences. Among these is Machado-Joseph disease, one of the most common spinocerebellar ataxias (MJD/SC...

    Authors: Kerstin Lindblad, Astrid Lunkes, Patricia Maciel, Giovanni Stevanin, Cecilia Zander, Thomas Klockgether, Tim Ratzlaff, Alexis Brice, Guy A. Rouleau, Tom Hudson, Georg Auburger and Martin Schalling
    Citation: Molecular Medicine 1996 2:BF03402204
  15. Epidermolysis bullosa (EB) is a group of heritable diseases that manifest as blistering and erosions of the skin and mucous membranes. In the dystrophic forms of EB (DEB), the diagnostic hallmark is abnormalit...

    Authors: Angela M. Christiano, Sal LaForgia, Amy S. Paller, Joseph McGuire, Hiroshi Shimizu and Jouni Uitto
    Citation: Molecular Medicine 1996 2:BF03402203
  16. Obesity, the condition of excessive accumulation of fat is a poorly understood disorder and is a risk factor for type II diabetes, hypertension, and hyperlipidaemia. Recently, a putative mouse obese gene was c...

    Authors: Klaus Giese, Wendy J. Fantl, Charles Vitt, James C. Stephans, Lawrence Cousens, Matthew Wachowicz and Lewis T. Williams
    Citation: Molecular Medicine 1996 2:BF03402202
  17. IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fcε receptors (FcεRII/CD23). ...

    Authors: Fateh Ouaaz, Francis W. Ruscetti, Bernard Dugas, Judy Mikovits, Henri Agut, Patrice Debr and M. Djavad Mossalayi
    Citation: Molecular Medicine 1996 2:BF03402201
  18. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to severe impairments in cognition, behavior, and motor skills. The mechanism(s) by which HIV-1 induces CNS di...

    Authors: Thomas E. Lane, Michael J. Buchmeier, Debbie D. Watry and Howard S. Fox
    Citation: Molecular Medicine 1996 2:BF03402200
  19. Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to bilirubin. Since bilirubin is a potent antioxidant and heme a pro-oxidant, HO may protect cel...

    Authors: Tory Prestera, Paul Talalay, Jawed Alam, Young I. Ahn, Patty J. Lee and Augustine M. K. Choi
    Citation: Molecular Medicine 1995 1:BF03401897
  20. T lymphocytes infiltrating airways during the allergic immune response play a fundamental role in recruiting other specialized cells, such as eosinophils, by secreting interleukin 5 (IL-5), and promoting local...

    Authors: Fabrizio Spinozzi, Elisabetta Agea, Onelia Bistoni, Nicola Forenza, Alessandro Monaco, Brunangelo Falini, Gabrio Bassotti, Fernando De Benedictis, Fausto Grignani and Alberto Bertotto
    Citation: Molecular Medicine 1995 1:BF03401896
  21. It has previously been observed that the insulin-producing cells of human pancreatic islets are more resistant to alloxan-, streptozotocin-, nitroprusside-, or cytokine-induced injury than those of mouse and r...

    Authors: Nils Welsh, Boris Margulis, L. A. Håkan Borg, Helena Jernberg Wiklund, Johan Saldeen, Malin Flodström, Maria Alice Mello, Arne Andersson, Daniel G. Pipeleers, Claes Hellerström and Decio L. Eizirik
    Citation: Molecular Medicine 1995 1:BF03401895
  22. We previously demonstrated the local production of the pleiotropic cytokine interleukin-6 (IL-6) in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), an animal model for the ...

    Authors: Koenraad Gijbels, Stefan Brocke, John S. Abrams and Lawrence Steinman
    Citation: Molecular Medicine 1995 1:BF03401894
  23. Recurrent and metastatic carcinoma of the colorectum remains a major problem, with survival at 5 years post curative resection still only about 50%. Moreover, up to 30% of patients who present with early stage...

    Authors: Jennifer E. Hardingham, Dusan Kotasek, Robert E. Sage, Michael C. Eaton, Vivienne H. Pascoe and Alexander Dobrovic
    Citation: Molecular Medicine 1995 1:BF03401893
  24. Macrophage migration inhibitory factor (MIF) was one of the first lymphokine activities to be discovered and was described almost 30 years ago to be a soluble factor(s) produced by activated T lymphocytes. In ...

    Authors: Toshihiko Nishino, Jürgen Bernhagen, Hideo Shiiki, Thierry Calandra, Kazuhiro Dohi and Richard Bucala
    Citation: Molecular Medicine 1995 1:BF03401892
  25. Rheumatoid factor (RF) is a characteristic but not pathognomic feature in patients with rheumatoid arthritis (RA). It is unknown whether the repertoire of immunoglobulin genes utilized by RF+ B cells of RA patien...

    Authors: Xiaowen He, Jörg J. Goronzy, Wanyun Zhong, Congping Xie and Cornelia M. Weyand
    Citation: Molecular Medicine 1995 1:BF03401891
  26. Therapeutic intervention designed to block expression of human immunodeficiency virus (HIV) at a cellular level may slow the clinical progression of HIV-1 disease.

    Authors: Salvatore T. Butera, Beverly D. Roberts, J. William Critchfield, Guofu Fang, Thomas McQuade, Stephen J. Gracheck and Thomas M. Folks
    Citation: Molecular Medicine 1995 1:BF03401890
  27. We investigated the human immunodeficiency virus (HIV) proviral DNA sequence and copy number in alveolar macrophages (AM) and peripheral blood monocytes (PBM) from 10 HIV-positive patients without any active c...

    Authors: Koh Nakata, Michael Weiden, Timothy Harkin, David Ho and William N. Rom
    Citation: Molecular Medicine 1995 1:BF03401889
  28. The histopathology of multiple sclerosis (MS) is characterized by a loss of myelin and oligodendrocytes, relative preservation of axons, and a modest inflammatory response. The reasons for this selective oligo...

    Authors: Timothy Vartanian, You Li, Meijuan Zhao and Kari Stefansson
    Citation: Molecular Medicine 1995 1:BF03401888
  29. Hereditary angioneurotic edema (HANE) is an autosomal dominant disease due to genetic alterations at the C1 inhibitor gene. Mutations within the C1 inhibitor gene are responsible for the molecular defect in ty...

    Authors: Javier G. Ocejo-Vinyals, Francisco Leyva-Cobián and José L. Fernández-Luna
    Citation: Molecular Medicine 1995 1:BF03401610
  30. The nervous system has been implicated in several inflammatory skin disorders based on evidence such as the role of stress in inducing lesions, symmetry of lesions, and sparing of denervated skin. Interleukin ...

    Authors: Laurence A. Turka, Richard E. Goodman, J. Lynn Rutkowski, Anders A. F. Sima, Andrew Merry, Raj S. Mitra, Tamara Wrone-Smith, Galen Toews, Robert M. Strieter and Brian J. Nickoloff
    Citation: Molecular Medicine 1995 1:BF03401609
  31. Cytokines and cytokine antagonists modulate human immunodeficiency virus (HIV) replication in vitro and may be involved in HIV disease pathogenesis. An understanding of these cytokine networks may suggest nove...

    Authors: Eric V. Granowitz, Bradford M. Saget, Monica Z. Wang, Charles A. Dinarello, Paul R. Skolnik and A. S. Fauci
    Citation: Molecular Medicine 1995 1:BF03401607
  32. Protein kinase CK2 (also known as casein kinase 2) is a messenger-independent protein serine/threonine kinase ubiquitously distributed in eukaryotes. CK2 has been found to phosphorylate a wide variety of cytos...

    Authors: Markus Gapany, Russell A. Faust, Sherif Tawfic, Alan Davis, George L. Adams, P. Leder and Khalil Ahmed
    Citation: Molecular Medicine 1995 1:BF03401606
  33. Insulin (1) and glutamic acid decarboxylase (GAD) (2) are both autoantigens in insulin-dependent diabetes mellitus (IDDM), but no molecular mechanism has been proposed for their association. We have identified a ...

    Authors: George Rudy, Natalie Stone, Leonard C. Harrison, Peter G. Colman, Peter McNair, Vladimir Brusic, Michelle B. French, Margo C. Honeyman, Brian Tait and Andrew M. Lew
    Citation: Molecular Medicine 1995 1:BF03401603
  34. We have previously demonstrated CD8+ T cell clonal dominance using a PCR assay for the CDR3 length of T cell receptors belonging to a limited number of TCRBV segments/families. In this study, we have modified thi...

    Authors: Joanita Monteiro, Ravi Hingorani, In-Hong Choi, Jack Silver, Robert Pergolizzi and Peter K. Gregersen
    Citation: Molecular Medicine 1995 1:BF03401602
  35. Creutzfeldt-Jakob disease (CJD) is a prion disease which is manifest as a sporadic, inherited, and transmissible neurodegenerative disorder. The mean age at onset of CJD is ∼60 years, and as such, many people ...

    Authors: Serena Spudich, James A. Mastrianni, Margaret Wrensch, Ruth Gabizon, Zeev Meiner, Irit Kahana, Hana Rosenmann, Esther Kahana and Stanley B. Prusiner
    Citation: Molecular Medicine 1995 1:BF03401601

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