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  1. Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) gene cause the syndrome of resistance to thyroid hormone (RTH). The clinical phenotype results from the antagonism of the normal TRα ...

    Authors: Rosemary Wong, Xu-Guang Zhu, Mark A. Pineda, Sheue-yann Cheng and Bruce D. Weintraub
    Citation: Molecular Medicine 1995 1:BF03401555
    Content type: Original Articles Published on:

  2. The Ity/Lsh/Bcg gene on mouse chromosome 1 regulates priming/activation of macrophages for antimicrobial and tumouricidal activity. A candidate gene expressed in macrophages has been identified by positional clon...

    Authors: C. Howard Barton, Simon H. Whitehead and Jenefer M. Blackwell
    Citation: Molecular Medicine 1995 1:BF03401551
    Content type: Original Articles Published on:

  3. Human immunodeficiency virus type 1 (HIV-1) is a lentivirus and shares with other members of this retroviral subfamily the ability to replicate in nondividing cells, in particular, cells of the monocyte/macrop...

    Authors: Larisa Dubrovsky, Peter Ulrich, Gerard J. Nuovo, Kirk R. Manogue, Anthony Cerami and Michael Bukrinsky
    Citation: Molecular Medicine 1995 1:BF03401569
    Content type: Original Articles Published on:

  4. Several immunotoxins in which antibodies are coupled to plant or bacterial toxins are now in clinical trials for the treatment of cancer. One of these is B3-LysPE38 in which MAb B3 which reacts with many human...

    Authors: Ulrich Brinkmann, Elisabeth Brinkmann and Ira Pastan
    Citation: Molecular Medicine 1995 1:BF03401568
    Content type: Original Articles Published on:

  5. Murine Nramp is a candidate for the macrophage resistance gene Ity/Lsh/Bcg. Sequence analysis of human NRAMP was undertaken to determine its role in man.

    Authors: Jenefer M. Blackwell, C. Howard Barton, Jacqueline K. White, Susan Searle, Anne-Marie Baker, Hazel Williams and Marie-Anne Shaw
    Citation: Molecular Medicine 1995 1:BF03401567
    Content type: Original Articles Published on:

  6. New vessel growth is often associated with ischemia, and hypoxic tissue has been identified as a potential source of angiogenic factors. In particular, ischemia is associated with the development of neovascula...

    Authors: David T. Shima, Anthony P. Adamis, Napoleone Ferrara, Kiang-Teck Yeo, Tet-Kin Yeo, Rapheal Allende, Judah Folkman and Patricia A. D’Amore
    Citation: Molecular Medicine 1995 1:BF03401566
    Content type: Original Articles Published on:

  7. Vascular smooth muscle cell (VSMC) proliferation following arterial injury plays a critical role in a variety of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angiopl...

    Authors: Mark W. Chang, Takeshi Ohno, David Gordon, Min Min Lu, Gary J. Nabel, Elizabeth G. Nabel and Jeffrey M. Leiden
    Citation: Molecular Medicine 1995 1:BF03401565
    Content type: Original Articles Published on:

  8. Cervical intraepithelial neoplasia (CIN) and cervical cancer have been shown to be strongly associated with infection by human papillomavirus (HPV). However, other factors may be contributory in the progressio...

    Authors: Kunle Odunsi, George Terry, Linda Ho, John Bell, Jack Cuzick and Trivadi S. Ganesan
    Citation: Molecular Medicine 1995 1:BF03401564
    Content type: Original Articles Published on:

  11. The identification of transcripts encoding putative olfactory receptors in mammalian germ cells (1) has generated the hypothesis that olfactory receptors may serve a chemosensory role in sperm Chemotaxis during f...

    Authors: Loren D. Walensky, A. Jane Roskams, Robert J. Lefkowitz, Solomon H. Snyder and Gabriele V. Ronnett
    Citation: Molecular Medicine 1995 1:BF03401561
    Content type: Original Articles Published on:

  15. Angiotensin converting enzyme inhibitor (ACEi) therapy delays the onset of renal failure in diabetic nephropathy and inhibits or delays the onset of proteinuria in several animal models.

    Authors: Emmanuel P. Peten, Liliane J. Striker, Agnes Fogo, Iekuni Ichikawa, Aneeta Patel and Gary E. Striker
    Citation: Molecular Medicine 1994 1:BF03403536
    Content type: Original Articles Published on:

  16. Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most important and best studied of these cytokines is tumor...

    Authors: Thomas D. Geppert, Charles E. Whitehurst, Patricia Thompson and Bruce Beutler
    Citation: Molecular Medicine 1994 1:BF03403535
    Content type: Original Articles Published on:

  17. Thirty-six mutations that cause Gaucher disease, the most common glycolipid storage disorder, are known. Although both alleles of most patients with the disease contain one of these mutations, in a few patient...

    Authors: Ernest Beutler, Anna Demina and Terri Gelbart
    Citation: Molecular Medicine 1994 1:BF03403534
    Content type: Original Articles Published on:

  18. The host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by proliferating within injured sites and c...

    Authors: Richard Bucala, Lori A. Spiegel, Jason Chesney, Margaret Hogan and Anthony Cerami
    Citation: Molecular Medicine 1994 1:BF03403533
    Content type: Original Articles Published on:

  19. Monozygotic (MZ) twinning is a poorly understood phenomenon that may result in subtle biologic differences between twins, despite their identical inheritance. These differences may in part account for discorda...

    Authors: Velia Trejo, Catherine Derom, Robert Vlietinck, William Ollier, Alan Silman, George Ebers, Robert Derom and Peter K. Gregersen
    Citation: Molecular Medicine 1994 1:BF03403532
    Content type: Original Articles Published on:

  20. Common variable immunodeficiency (CVID) is defined by hypogammaglobulinemia and increased susceptibility to infections. The gene defect responsible for CVID remains unknown.

    Authors: Monika Belickova, Harry W. Schroeder Jr., Y. L. Guan, Joseph Brierre, Seth Berney, Max D. Cooper and Josef T. Prchal
    Citation: Molecular Medicine 1994 1:BF03403531
    Content type: Original Articles Published on:

  21. Reactive arthritis (ReA) is a T cell mediated inflammatory process. The immune response is primarily directed against a triggering organism, although autoimmunity has been invoked in long-lasting, antibiotic-r...

    Authors: Andreas K. H. Mertz, Angelika Daser, Mikael Skurnik, Karl-Heinz Wiesmüller, Jürgen Braun, Heiner Appel, Steven Batsford, Peihua Wu, Armin Distler and Joachim Sieper
    Citation: Molecular Medicine 1994 1:BF03403530
    Content type: Original Articles Published on:

  22. This investigation deals with the molecular mechanism of anti-human immunodeficiency virus type 1 (HIV-1) action of pentoxifylline (PTX) [1-(5′-oxohexyl)-3,7-dimethylxanthine] a drug widely used for the treatm...

    Authors: Debajit K. Biswas, Christoph M. Ahlers, Bruce J. Dezube and Arthur B. Pardee
    Citation: Molecular Medicine 1994 1:BF03403529
    Content type: Original Articles Published on:

  23. It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We showed previously that mi...

    Authors: Hansruedi Büeler, Alex Raeber, Andreas Sailer, Marek Fischer, Adriano Aguzzi and Charles Weissmann
    Citation: Molecular Medicine 1994 1:BF03403528
    Content type: Original Articles Published on:

  24. Major symptoms and death from systemic Bacillus anthracis infections are mediated by the action of the pathogen’s lethal toxin on host macrophages. High levels of the toxin are cytolytic to macrophages, whereas l...

    Authors: Philip C. Hanna, Benjamin A. Kruskal, R. Allen B. Ezekowitz, Barry R. Bloom and R. John Collier
    Citation: Molecular Medicine 1994 1:BF03403527
    Content type: Original Articles Published on:
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ISSN: 1528-3658