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  1. Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. The use of adeno-associated virus (AAV) vectors for gene therapy in human clinical trials has shown promise, as AAV generally ca...

    Authors: Hung-Chen Wang, Kuang-I Cheng, Kuang-Yi Tseng, Aij-Lie Kwan and Lin-Li Chang
    Citation: Molecular Medicine 2023 29:22
    Content type: Research article Published on:

  2. Sepsis is caused by the dysregulated immune response due to an initial infection and results in significant morbidity and mortality in humans. Extracellular cold inducible RNA binding protein (eCIRP) is a nove...

    Authors: Timothy Borjas, Asha Jacob, Molly Kobritz, Gaifeng Ma, Chuyi Tan, Vihas Patel, Gene F. Coppa, Monowar Aziz and Ping Wang
    Citation: Molecular Medicine 2023 29:21
    Content type: Research article Published on:

  3. Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast subpopulations play different roles. A subpopulation of fibroblasts expressing CD90, a 25–37 kDa glycosylphosphatidylino...

    Authors: Feng Zeng, Mengxiang Gao, Shan Liao, Zihua Zhou, Gengqiu Luo and Yanhong Zhou
    Citation: Molecular Medicine 2023 29:20
    Content type: Review Published on:

  4. With the increasing morbidity and mortality of preeclampsia (PE), it has posed a huge challenge to public health. Previous studies have reported endoplasmic reticulum (ER) stress could contribute to trophoblas...

    Authors: Yangyang Chen, Xiaoxia Liu, Lun Li, Xiyang He, Fanghui Zheng, Yang Zhang, Hui Gao, Zhishan Jin, Di Wu, Qianhua Wang, Hui Tao, Yin Zhao, Weifang Liu and Li Zou
    Citation: Molecular Medicine 2023 29:19
    Content type: Research article Published on:

  6. Osteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation. Indole-3-propionic acid (IPA) is a tryptophan metabolite secreted by intestinal flora...

    Authors: Huangming Zhuang, Xunshan Ren, Fuze Jiang and Panghu Zhou
    Citation: Molecular Medicine 2023 29:17
    Content type: Research article Published on:

  7. Chorioamnionitis is a common cause of preterm birth and leads to serious complications in newborns. The objective of this study was to investigate the role of the Hippo signaling pathway in lung branching morp...

    Authors: Hung-Shuo Ko, Vincent Laiman, Po-Nien Tsao, Chung-Ming Chen and Hsiao-Chi Chuang
    Citation: Molecular Medicine 2023 29:16
    Content type: Research article Published on:

  8. Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Tar...

    Authors: Doudou Jing, Xuanzuo Chen, Zhenhao Zhang, Fengxia Chen, Fuhua Huang, Zhicai Zhang, Wei Wu, Zengwu Shao and Feifei Pu
    Citation: Molecular Medicine 2023 29:15
    Content type: Research article Published on:

  9. Germline mutations in cancer susceptibility genes were identified in pancreatic cancer (PanC) patients with a sporadic disease and in those unselected for family cancer history.

    Authors: Francesca Tavano, Domenica Gioffreda, Andrea Fontana, Orazio Palmieri, Annamaria Gentile, Tiziana Latiano, Anna Latiano, Tiziana Pia Latiano, Matteo Scaramuzzi, Evaristo Maiello, Francesca Bazzocchi and Francesco Perri
    Citation: Molecular Medicine 2023 29:14
    Content type: Research article Published on:

  10. Acute respiratory distress syndrome (ARDS), a life-threatening condition during critical illness, is a common complication of COVID-19. It can originate from various disease etiologies, including severe infect...

    Authors: Richa Batra, Rie Uni, Oleh M. Akchurin, Sergio Alvarez-Mulett, Luis G. Gómez-Escobar, Edwin Patino, Katherine L. Hoffman, Will Simmons, William Whalen, Kelsey Chetnik, Mustafa Buyukozkan, Elisa Benedetti, Karsten Suhre, Edward Schenck, Soo Jung Cho, Augustine M. K. Choi…
    Citation: Molecular Medicine 2023 29:13
    Content type: Short report Published on:

  11. Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative disease that affects upper and lower motor neurons. As the molecular basis of the disease is still elusive, the development of high-t...

    Authors: Kyriaki Founta, Dimitra Dafou, Eirini Kanata, Theodoros Sklaviadis, Theodoros P. Zanos, Anastasios Gounaris and Konstantinos Xanthopoulos
    Citation: Molecular Medicine 2023 29:12
    Content type: Research article Published on:

  13. Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the treatment of hematologic malignancie...

    Authors: Tianming Zhao, Qiang He, Shurong Xie, Huien Zhan, Cheng Jiang, Shengbin Lin, Fangshu Liu, Cong Wang, Guo Chen and Hui Zeng
    Citation: Molecular Medicine 2023 29:10
    Content type: Research article Published on:

  14. Retinal ganglion cells (RGCs) apoptosis is a vital manifestation of retinal ischemia/reperfusion (I/R) injury, yet the underlying mechanisms are not well understood. The contribution of long noncoding RNAs (ln...

    Authors: Yuqing Feng, Jinfang Lu, Xujun Peng, Yanni Ge, Ran Zhang and Huiling Li
    Citation: Molecular Medicine 2023 29:9
    Content type: Research Article Published on:

  15. Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate se...

    Authors: Harold A. Silverman, Aisling Tynan, Tyler D. Hepler, Eric H. Chang, Manojkumar Gunasekaran, Jian Hua Li, Tomás S. Huerta, Tea Tsaava, Qing Chang, Meghan E. Addorisio, Adrian C. Chen, Dane A. Thompson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey and Sangeeta S. Chavan
    Citation: Molecular Medicine 2023 29:4
    Content type: Research article Published on:

  16. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain development and socio-cognitive abilities. The pathogenesis of this condition points out the involvement of genetic and...

    Authors: Amin Ravaei, Marco Emanuele, Giovanni Nazzaro, Luciano Fadiga and Michele Rubini
    Citation: Molecular Medicine 2023 29:8
    Content type: Mini-review Published on:

  17. Bladder cancer (BCa) is the most common malignant tumor of the urinary system, with transitional cell carcinoma (TCC) being the predominant type. EP300 encodes a lysine acetyltransferase that regulates a large su...

    Authors: Mayao Luo, Yifan Zhang, Zhuofan Xu, Shidong Lv, Qiang Wei and Qiang Dang
    Citation: Molecular Medicine 2023 29:7
    Content type: Research article Published on:

  18. Activated Cdc42-associated kinase 1 (ACK1) is a promising druggable target for cancer, but its inhibitors only showed moderate effects in clinical trials. The study aimed to investigate the underlying mechanis...

    Authors: Jinhong Zhu, Kui Cao, Meng Zhao, Keru Ma, Xiangyu Jiang, Yuwen Bai, Xiaodong Ling and Jianqun Ma
    Citation: Molecular Medicine 2023 29:6
    Content type: Research article Published on:

  19. Diarrheal irritable bowel syndrome (IBS-D) is a common chronic functional gastrointestinal disorder, and the underlying pathogenic mechanism is still unclear. Animal models that mimic the pathological state of...

    Authors: Qian Chen, Hua Zhang, Chang-Yue Sun, Qing-Ying He, Rui-Rong Zhang, Bin-Fei Luo, Zi-Hao Zhou and Xiao-Fan Chen
    Citation: Molecular Medicine 2023 29:5
    Content type: Research Article Published on:

  20. Cerebral ischemia/reperfusion (I/R) is a pathological process that occurs in ischemic stroke. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) have been verified to relieve cerebral I/R-induced i...

    Authors: Xiaowei Xie, Yu Cao, Liangping Dai and Dingzhou Zhou
    Citation: Molecular Medicine 2023 29:3
    Content type: Research Article Published on:

  22. Long intergenic non-coding RNA 00963 (LINC00963) is an oncogenic lncRNA in human cancers. However, little is known on how it impacts the pathogenesis of lung adenocarcinoma (LUAD).

    Authors: Ronghang Hu, Baobin Xu, Jiajun Ma, Linfeng Li, Liming Zhang, Li Wang, Jiebo Zhu, Tao Guo, Heng Zhang and Shaoqiang Wang
    Citation: Molecular Medicine 2023 29:1
    Content type: Research article Published on:

  23. Recurrent spontaneous abortion (RSA), is a dangerous pregnancy-related condition and is a subject of debate in the gynaecology and obstetrics communities. The objective of this study was to determine the funct...

    Authors: Yuhan Duan, Huijia Fu, Jiayu Huang, Nanlin Yin, Linhong Liu and Xiru Liu
    Citation: Molecular Medicine 2022 28:165
    Content type: Research Article Published on:

  24. High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in ...

    Authors: Jaemin Shin, Young Hun Kim, Bin Lee, Jae Ho Chang, Hee Youn Choi, Hoojung Lee, Ki Chan Song, Man Sup Kwak, Ji Eun Choi and Jeon-Soo Shin
    Citation: Molecular Medicine 2022 28:164
    Content type: Research Article Published on:

  25. Intestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear. Here, we report ...

    Authors: Ying-Ya Cao, Yuan Zhang, Wuyun Gerile, Yan Guo, Li-Na Wu, Li-Li Wu, Kai Song, Wei-Hua Lu and Jian-Bo Yu
    Citation: Molecular Medicine 2022 28:163
    Content type: Research Article Published on:

  26. Randall’s plaques (RP) are identified as anchored sites for kidney calcium oxalate stones, but the mechanism remains unclear. Given the importance of osteogenic-like cells in RP formation and OCT4 in reprogram...

    Authors: Zewu Zhu, Fang Huang, Yingcheng Jiang, Shuhao Ruan, Minghui Liu, Youjie Zhang, Yongchao Li, Jinbo Chen, Yu Cui, Zhiyong Chen, Hequn Chen and Feng Zeng
    Citation: Molecular Medicine 2022 28:162
    Content type: Research article Published on:

  27. Gut microbiota plays a critical role in the maintenance of host health. As a low-cost and genetically tractable vertebrate model, zebrafish have been widely used for biological research. Zebrafish and humans s...

    Authors: Hui Xia, Huimin Chen, Xue Cheng, Mingzhu Yin, Xiaowei Yao, Jun Ma, Mengzhen Huang, Gang Chen and Hongtao Liu
    Citation: Molecular Medicine 2022 28:161
    Content type: Review Published on:

  29. This study aims to explore the protective role of ethanol extract from Chimonanthus nitens Oliv. leaf (COE) in hyperlipidemia via the leptin/Janus kinase 2 (JAK2)/signal transducer and activator of transcription ...

    Authors: Jianping Pan, Xilin Ouyang, Qi Jin, Wei Wang, Jiali Xie, Baoming Yu, Zhijie Ling, Qizhen Wu and Baoping Zheng
    Citation: Molecular Medicine 2022 28:159
    Content type: Research article Published on:

  30. Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain les...

    Authors: Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang and Jing Zhang
    Citation: Molecular Medicine 2022 28:158
    Content type: Research article Published on:

  31. Sepsis is a syndrome where the dysregulated host response to infection threatens the life of the patient. The isoform of the cholesteryl-ester transfer protein (CETPI) is synthesized in the small intestine, an...

    Authors: Eréndira G. Pérez-Hernández, Víctor De la Puente-Díaz de León, Ismael Luna-Reyes, Blanca Delgado-Coello, José Sifuentes-Osornio and Jaime Mas-Oliva
    Citation: Molecular Medicine 2022 28:157
    Content type: Research article Published on:

  32. The use of doxorubicin is associated with an increased risk of acute and long-term cardiomyopathy. Despite the constantly growing number of cancer survivors, little is known about the transcriptional mechanism...

    Authors: Justyna Totoń-Żurańska, Joanna Sulicka-Grodzicka, Michał T. Seweryn, Ewelina Pitera, Przemysław Kapusta, Paweł Konieczny, Leszek Drabik, Maria Kołton-Wróż, Bernadeta Chyrchel, Ewelina Nowak, Andrzej Surdacki, Tomasz Grodzicki and Paweł P. Wołkow
    Citation: Molecular Medicine 2022 28:156
    Content type: Research article Published on:

  33. Exenatide is a stable analogue of glucagon-like peptide 1 that can reduce postprandial hyperglycemia and has been utilized as adjunctive therapy for type 1 diabetes mellitus (T1DM). The human umbilical cord is...

    Authors: Wei Wang, Yahao Wang, Jingwei Chi, Xiaojun Tan, Jianxia Hu, Xiaolong Ma, Xiaofang Sun, Kui Che, Wenshan Lv and Yangang Wang
    Citation: Molecular Medicine 2022 28:155
    Content type: Research article Published on:

  34. Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide but has no effective treatment. Amyloid beta (Aβ) protein, a primary risk factor for AD, accumulates and aggregates in the brain ...

    Authors: Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara and Kohtaro Takei
    Citation: Molecular Medicine 2022 28:154
    Content type: Research article Published on:

  35. Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which manifests as a hyper inflammatory proce...

    Authors: Cíntia Barros Santos-Rebouças, Rafael Mina Piergiorge, Cristina dos Santos Ferreira, Raquel de Seixas Zeitel, Alexandra Lehmkuhl Gerber, Marta Cristine Felix Rodrigues, Ana Paula de Campos Guimarães, Rodrigo Moulin Silva, Adriana Rodrigues Fonseca, Rangel Celso Souza, Ana Tereza Antunes Monteiro de Souza, Átila Duque Rossi, Luís Cristóvão de Moraes Sobrino Porto, Cynthia Chester Cardoso and Ana Tereza Ribeiro de Vasconcelos
    Citation: Molecular Medicine 2022 28:153
    Content type: Research article Published on:

  36. Acute renal injury (AKI) secondary to ischemia reperfusion (IR) injury continues to be a significant perioperative problem and there is no effective treatment. Mindin belongs to the mindin/F-spondin family and...

    Authors: Tao Bai, Xiong Wang, Cong Qin, Kang Yang, Zhiguo Duan, Zhixiu Cao, Jiaqian Liang, Lei Wang, Jingdong Yuan and Pengcheng Luo
    Citation: Molecular Medicine 2022 28:152
    Content type: Research article Published on:

  37. Endometriosis (EMS) is a “tumour-like” gynaecological disease with distant metastasis, and studies have shown that EMS can induce distant metastasis through vascular vessels, but the driving factors and their ...

    Authors: Caiqi Ma, Wei Huang, Hui Wang, Wenxia Yao, Min Liang, Guifang Yu and Xinke Zhou
    Citation: Molecular Medicine 2022 28:151
    Content type: Research article Published on:

  38. Therapeutic options for steroid-resistant non-type 2 inflammation in obstructive lung diseases are lacking. Alveolar macrophages are central in the progression of these diseases by releasing proinflammatory cy...

    Authors: Daniel Weidinger, Kaschin Jamal Jameel, Desiree Alisch, Julian Jacobsen, Paul Bürger, Matthias Ruhe, Faisal Yusuf, Simon Rohde, Klemens Störtkuhl, Peter Kaufmann, Juliane Kronsbein, Marcus Peters, Hanns Hatt, Nikolaos Giannakis and Jürgen Knobloch
    Citation: Molecular Medicine 2022 28:150
    Content type: Research article Published on:

  40. Autoinflammatory diseases, a diverse group of inherited conditions characterized by excessive innate immune activation, have limited therapeutic options. Neuroimmune circuits of the inflammatory reflex control...

    Authors: Ibrahim T. Mughrabi, Mahendar Ochani, Mirza Tanovic, Ping Wang, Betty Diamond, Barbara Sherry, Valentin A. Pavlov, Seza Ozen, Daniel L. Kastner, Jae Jin Chae and Yousef Al-Abed
    Citation: Molecular Medicine 2022 28:148
    Content type: Short report Published on:

  41. Deregulated autophagy in diabetes has been a field of many experimental studies recently. Impaired autophagy in diabetic kidneys orchestrates every step of diabetic nephropathy (DN) pathogenesis. This study ai...

    Authors: Mona M. Watany, Hemat E. El-Horany, Marwa M. Elhosary and Ahmed A. Elhadidy
    Citation: Molecular Medicine 2022 28:147
    Content type: Research article Published on:

  42. The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides d...

    Authors: Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour and Nikolay V. Dokholyan
    Citation: Molecular Medicine 2022 28:146
    Content type: Review Published on:

  43. Since angiogenesis occurs as the pathological process following myocardial infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a cardioprotective strategy. CD44 has been implicat...

    Authors: Qing Zhang, Li Chen, Liyi Huang, Hongxin Cheng, Lu Wang, Lin Xu, Danrong Hu, Chengqi He, Chenying Fu and Quan Wei
    Citation: Molecular Medicine 2022 28:145
    Content type: Research article Published on:

  45. Mesenchymal stem cells (MSCs) are multipotent stromal cells and could exert hepatoprotective effects against acute liver injury, steatohepatitis, and fibrogenesis. Here, we evaluated the effects of human adipo...

    Authors: Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchishima and Mikihiro Tsutsumi
    Citation: Molecular Medicine 2022 28:143
    Content type: Research article Published on:

  46. Activated microglia play a key role in initiating the inflammatory cascade following ischemic stroke and exert proinflammatory or anti-inflammatory effects, depending on whether they are polarized toward the M...

    Authors: Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang and Liangdong Li
    Citation: Molecular Medicine 2022 28:142
    Content type: Research article Published on:

  47. Tetrandrine, a bisbenzylisoquinoline (BBI) alkaloid extracted from Stephania tetrandra (S. Moore), and is widely used in several diseases such as tuberculosis, hyperglycemia, malaria, and tumors. Tetrandrine was ...

    Authors: Jiarui Li, Xiang Li, Shengji Zhou, Yuxin Wang, Yang Lu, Quan Wang and Fengchao Zhao
    Citation: Molecular Medicine 2022 28:141
    Content type: Research article Published on:

  48. Analyzing disease–disease relationships plays an important role for understanding etiology, disease classification, and drug repositioning. However, as cardiovascular diseases with causative links, the molecul...

    Authors: Lin Chen, Ya-Nan Yu, Jun Liu, Yin-ying Chen, Bo Wang, Yi-Fei Qi, Shuang Guan, Xi Liu, Bing Li, Ying-Ying Zhang, Yuanhui Hu and Zhong Wang
    Citation: Molecular Medicine 2022 28:140
    Content type: Research article Published on:

  49. Neuroinflammation is a major mechanism in neurodegenerative diseases such as Alzheimer’s disease (AD), which is a major healthcare problem. Notwithstanding of ample researches figured out possible molecular me...

    Authors: Esraa M. Mosalam, Aya Ibrahim Elberri, Amany Said Sallam, Heba Rady Salem, Ebtehal M. Metwally, Mahmoud S. Abdallah, Moataz A. Shaldam and Hend E. Abo Mansour
    Citation: Molecular Medicine 2022 28:139
    Content type: Research article Published on:

  50. The long chain non-coding RNA HOXA11-OS was recently identified. Increasing studies have shown that HOXA11-OS has regulatory effects on genes in gastric cancer, prostate cancer, and various kidney diseases, bu...

    Authors: Xiuhong Pan, Shanshan Chen, Ruiwen Shen, Sen Liu and Yanwu You
    Citation: Molecular Medicine 2022 28:138
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658