Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 1 of 42

  1. Dysfunctional osteogenesis of bone marrow mesenchymal stem cells (BMSCs) plays an important role in osteoporosis occurrence and development. However, the molecular mechanisms of osteogenic differentiation rema...

    Authors: Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang and Minghai Wang

    Citation: Molecular Medicine 2021 27:153

    Content type: Research article

    Published on:

  2. Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is r...

    Authors: Qian Jin, He Yang, Zhao Jing, Wu Hong-hua, Song Ben-jing, Wang Li-ting, Ye Li-juan, Xu Wei, Kang Xia, Wu Juan and Zheng Wei

    Citation: Molecular Medicine 2021 27:152

    Content type: Research article

    Published on:

  3. We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortal...

    Authors: Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu and Yongzhe Li

    Citation: Molecular Medicine 2021 27:151

    Content type: Research article

    Published on:

  4. Alzheimer’s disease (AD), the most common form of dementia, is caused by the degeneration of the central nervous system (CNS). A previous study reported that signal transducer and activator of transcription 3 ...

    Authors: Chen Li, Ruili Wang, Youyou Zhang, Chunting Hu and Qiaoya Ma

    Citation: Molecular Medicine 2021 27:150

    Content type: Research article

    Published on:

  5. Thrombocytopenia is one of the most common hematological disease that can be life-threatening caused by bleeding complications. However, the treatment options for thrombocytopenia remain limited.

    Authors: Jing Lin, Jing Zeng, Sha Liu, Xin Shen, Nan Jiang, Yue-Song Wu, Hong Li, Long Wang and Jian-Ming Wu

    Citation: Molecular Medicine 2021 27:149

    Content type: Research article

    Published on:

  6. Imatinib (IM), targeting of BCR-ABL1 tyrosine kinase, is currently one of the first-line choices in the treatment of chronic myeloid leukemia (CML). This study aims to explore the molecular mechanisms underlyi...

    Authors: Yao-hua Lu and Zhong-yi Huang

    Citation: Molecular Medicine 2021 27:148

    Content type: Research article

    Published on:

  7. Patients with salt-sensitive hypertension are often accompanied with severe renal damage and accelerate to end-stage renal disease, which currently lacks effective treatment. Fibroblast growth factor 21 (FGF21...

    Authors: Hua-Chun Weng, Xin-Yu Lu, Yu-Peng Xu, Yi-Hong Wang, Dan Wang, Yi-Ling Feng, Zhang Chi, Xiao-Qing Yan, Chao-Sheng Lu and Hong-Wei Wang

    Citation: Molecular Medicine 2021 27:147

    Content type: Research article

    Published on:

  8. Adipose-derived mesenchymal stem cells (ADSCs) are an important focus in regenerative medicine. However, the biological function of ADSCs in the wound repair of diabetic foot ulcers (DFUs) remains unclear. Thi...

    Authors: Jie Zhou, Tianhong Wei and Zhiyou He

    Citation: Molecular Medicine 2021 27:146

    Content type: Research article

    Published on:

  9. The alarming trend of paediatric obesity deserves our greatest awareness to hinder the early onset of metabolic complications impacting growth and functionality. Presently, insight into molecular mechanisms of...

    Authors: Margot De Spiegeleer, Ellen De Paepe, Lieven Van Meulebroek, Inge Gies, Jean De Schepper and Lynn Vanhaecke

    Citation: Molecular Medicine 2021 27:145

    Content type: Review

    Published on:

  10. LncRNA-ATB is a long noncoding RNA (lncRNA) activated by transforming growth factor β (TGF-β) and it has important biological functions in tumours and nontumour diseases. Meanwhile, TGF-β is the most critical ...

    Authors: Yinhui Li, Tao Ding, Haiyan Hu, Tingting Zhao, Chao Zhu, Jiarong Ding, Jihang Yuan and Zhiyong Guo

    Citation: Molecular Medicine 2021 27:143

    Content type: Research article

    Published on:

  11. Cardiotoxicity is a common complication following anthracycline chemotherapy and represents one of the serious adverse reactions affecting life, which severely limits the effective use of anthracyclines in can...

    Authors: Guoxing Wan, Peinan Chen, Xue Sun, Xiaojun Cai, Xiongjie Yu, Xianhe Wang and Fengjun Cao

    Citation: Molecular Medicine 2021 27:142

    Content type: Research article

    Published on:

  12. We aimed to investigate the functions and underlying mechanism of lncRNA SNHG1 in bone differentiation and angiogenesis in the development of osteoporosis.

    Authors: Xiao Yu, Peng-Ze Rong, Meng-Sheng Song, Ze-Wen Shi, Gong Feng, Xian-Jun Chen, Lin Shi, Cheng-Hao Wang and Qing-Jiang Pang

    Citation: Molecular Medicine 2021 27:141

    Content type: Research article

    Published on:

  13. Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance in multiple solid tumours. However, there is a lack of universal measures of CAFs in c...

    Authors: Yu-feng Chen, Zhao-liang Yu, Min-yi Lv, Ze-rong Cai, Yi-feng Zou, Ping Lan, Xiao-jian Wu and Feng Gao

    Citation: Molecular Medicine 2021 27:139

    Content type: Research article

    Published on:

  14. Obesity-related nephropathy (ORN) has become one of the leading causes of end-stage renal disease and has tripled over the past decade. Previous studies have demonstrated that decreased reactive oxygen species...

    Authors: Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang and Li-Yu He

    Citation: Molecular Medicine 2021 27:137

    Content type: Research article

    Published on:

  15. Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang

    Citation: Molecular Medicine 2021 27:136

    Content type: Correction

    Published on:

    The original article was published in Molecular Medicine 2019 25:43

  16. Cardiac arrest (CA) results in loss of blood circulation to all tissues leading to oxygen and metabolite dysfunction. Return of blood flow and oxygen during resuscitative efforts is the beginning of reperfusio...

    Authors: Muhammad Shoaib, Nancy Kim, Rishabh C. Choudhary, Tai Yin, Koichiro Shinozaki, Lance B. Becker and Junhwan Kim

    Citation: Molecular Medicine 2021 27:135

    Content type: Research article

    Published on:

  17. Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosyntheti...

    Authors: Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey and Sangeeta S. Chavan

    Citation: Molecular Medicine 2021 27:133

    Content type: Research article

    Published on:

  18. The FOXP3/miR-146a/NF-κB axis was previously reported to modulate the induction and function of CD4+ Treg cells to alleviate oral lichen planus. Also, other signaling pathways including microRNA-155-IFN-γ loop...

    Authors: Zhen Huang, Fen Liu, Wenjuan Wang, Shaobo Ouyang, Ting Sang, Zikun Huang, Lan Liao and Jun Wu

    Citation: Molecular Medicine 2021 27:132

    Content type: Research article

    Published on:

  19. Myocardial dysfunction caused by sepsis (SIMD) leads to high mortality in critically ill patients. We investigated the function and mechanism of long non-coding RNA MAPKAPK5-AS1 (lncRNA MAPKAPK-AS1) on lipopol...

    Authors: Weiwei Chen, Guangyuan Gao, Mengjie Yan, Ming Yu, Kaiyao Shi and Ping Yang

    Citation: Molecular Medicine 2021 27:131

    Content type: Research article

    Published on:

  20. Host inflammation contributes to determine whether SARS-CoV-2 infection causes mild or life-threatening disease. Tools are needed for early risk assessment.

    Authors: Nicola I. Lorè, Rebecca De Lorenzo, Paola M. V. Rancoita, Federica Cugnata, Alessandra Agresti, Francesco Benedetti, Marco E. Bianchi, Chiara Bonini, Annalisa Capobianco, Caterina Conte, Angelo Corti, Roberto Furlan, Paola Mantegani, Norma Maugeri, Clara Sciorati, Fabio Saliu…

    Citation: Molecular Medicine 2021 27:129

    Content type: Research article

    Published on:

  21. Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played a tumorigenic role in various types of cancer and miR-23b-5p was down-regulated in human mese...

    Authors: Hui Cheng, Jie Ding, Gusheng Tang, Aijie Huang, Lei Gao, Jianmin Yang and Li Chen

    Citation: Molecular Medicine 2021 27:128

    Content type: Research article

    Published on:

  22. d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays...

    Authors: Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu, Yuanjian Yang and Wei Wang

    Citation: Molecular Medicine 2021 27:127

    Content type: Research article

    Published on:

  23. Immune checkpoint inhibitors (ICIs) have witnessed the achievements of convincing clinical benefits that feature the significantly prolonged overall survival (OS) of patients suffering from advanced non-small ...

    Authors: Xilin Hu, Hanlin Xu, Qianwen Xue, Ruran Wen, Wenjie Jiao and Kaihua Tian

    Citation: Molecular Medicine 2021 27:126

    Content type: Research article

    Published on:

  24. C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Disc...

    Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son and Jeon-Soo Shin

    Citation: Molecular Medicine 2021 27:125

    Content type: Research article

    Published on:

  25. Inflammation plays an important role in the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The long non-coding RNA (lncRNA) MINCR is closely related to inflammation inju...

    Authors: Wei Gao and Ying Zhang

    Citation: Molecular Medicine 2021 27:124

    Content type: Research article

    Published on:

  26. Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase...

    Authors: Wujun Chen, Yingjie Zhong, Nuan Feng, Zhu Guo, Shuai Wang and Dongming Xing

    Citation: Molecular Medicine 2021 27:123

    Content type: Review

    Published on:

  27. Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. Th...

    Authors: Paola Allavena, Elisabeth Digifico and Cristina Belgiovine

    Citation: Molecular Medicine 2021 27:121

    Content type: Review

    Published on:

  28. Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particula...

    Authors: Martin Begemann, Oliver Gross, Dominik Wincewicz, Rüdiger Hardeland, Vinicius Daguano Gastaldi, Eduard Vieta, Karin Weissenborn, Kamilla W. Miskowiak, Onnen Moerer and Hannelore Ehrenreich

    Citation: Molecular Medicine 2021 27:120

    Content type: Review

    Published on:

  29. While anti-tumor necrosis factor alpha (TNF-α) therapy has been proven effective in inflammatory bowel disease (IBD), approximately 40% of patients lose the response. Transmembrane TNF-α (mTNF-α) expression in...

    Authors: Xiaoyan Miao, Ren Mao, Yujia You, Huichao Zhou, Chen Qiu, Xuehua Li, Zhihui Chen, Jie Ren, Minhu Chen, Ping Wang, Rongqin Zheng and Tinghui Yin

    Citation: Molecular Medicine 2021 27:119

    Content type: Research article

    Published on:

  30. The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the activ...

    Authors: Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han and Pei Jiang

    Citation: Molecular Medicine 2021 27:118

    Content type: Research article

    Published on:

  31. GINS4, an indispensable component of the GINS complex, is vital for a variety of cancer. However, no known empirical research has focused on exploring relationships between GINS4 and glioma. Thus, this study aims...

    Authors: Binfeng Liu, Zhendong Liu, Yanbiao Wang, Xiaoyu Lian, Zhibin Han, Xingbo Cheng, Yongjie Zhu, Runze Liu, Yaoye Zhao and Yanzheng Gao

    Citation: Molecular Medicine 2021 27:117

    Content type: Research article

    Published on:

  32. Osteoarthritis (OA) is the most prevalent chronic joint disease, and is hard to be cured at present. Cytokine receptor-like factor 1 (CRLF1) has been identified as an upregulated gene in OA cartilage. However,...

    Authors: Hao Xu, Changrong Ding, Cuicui Guo, Shuai Xiang, Yingzhen Wang, Bing Luo and Hongfei Xiang

    Citation: Molecular Medicine 2021 27:116

    Content type: Research article

    Published on:

  33. Acute lung injury is an important factor that leads to the death of patients with pneumonia. Previous studies have shown that nicotinamide (NAM) plays a role in reducing cell damage, so this study explored the...

    Authors: Qun Zhang, Junyao Li, Haixia Zhong and Yanling Xu

    Citation: Molecular Medicine 2021 27:115

    Content type: Research article

    Published on:

  34. Changes in DNA methylation of immunosuppressive checkpoints may impact express and consequently affect antigen processing and presentation by tumor cells and facilitates evasion of immunosurveillance and lead ...

    Authors: Yuanyuan Zhang, Lei zhang, Hongru Sun, Ying Liu, Jing Xu, Hao Huang, Jinming Fu, Ding Zhang, Tian Tian, Yashuang Zhao and Guiyu Wang

    Citation: Molecular Medicine 2021 27:114

    Content type: Research article

    Published on:

  35. Increasing evidence has indicated that circular RNAs (circRNAs) play a role in various diseases. However, the influence of circRNAs in nephritis remains unknown.

    Authors: Peng-Wei Guo, Hai-Ting Huang, Jing Ma, Yao Zuo, Dan Huang, Lin-Lin He, Zi-Ming Wan, Cheng Chen, Fa-Fen Yang and Yan-Wu You

    Citation: Molecular Medicine 2021 27:113

    Content type: Research article

    Published on:

  36. The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology’s ability to investigate and respond to a novel pathogen and modern medicine’s ability to marshal effective fron...

    Authors: Douglas F. Nixon, Daniela Marín-Hernández and Nathaniel Hupert

    Citation: Molecular Medicine 2021 27:112

    Content type: Perspective

    Published on:

  37. Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6), a unique histone deacetylase with two functional catalytic d...

    Authors: Ping Liu, Ji Xiao, Yiliang Wang, Xiaowei Song, Lianzhou Huang, Zhe Ren, Kaio Kitazato and Yifei Wang

    Citation: Molecular Medicine 2021 27:110

    Content type: Review

    Published on:

  38. Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-214 is possibly implicated in bronchopulmonary dysplasia (BPD) have not ...

    Authors: Zhi-Qun Zhang, Hui Hong, Jing Li, Xiao-Xia Li and Xian-Mei Huang

    Citation: Molecular Medicine 2021 27:109

    Content type: Research article

    Published on:

    The Correction to this article has been published in Molecular Medicine 2021 27:134

  39. Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism...

    Authors: Sofia Moran-Ramos, Luis Macias-Kauffer, Blanca E. López-Contreras, Hugo Villamil-Ramírez, Elvira Ocampo-Medina, Paola León-Mimila, Blanca E. del Rio-Navarro, Omar Granados-Portillo, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Armando R. Tovar, Nimbe Torres, Francisco J. Gomez-Perez, Carlos Aguilar-Salinas and Samuel Canizales-Quinteros

    Citation: Molecular Medicine 2021 27:108

    Content type: Research article

    Published on:

  40. Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial...

    Authors: Rodrigo R. R. Duarte, Dennis C. Copertino Jr., Luis P. Iñiguez, Jez L. Marston, Yaron Bram, Yuling Han, Robert E. Schwartz, Shuibing Chen, Douglas F. Nixon and Timothy R. Powell

    Citation: Molecular Medicine 2021 27:105

    Content type: Research article

    Published on:

  41. The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be c...

    Authors: Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara and Kenneth R. Chien

    Citation: Molecular Medicine 2021 27:102

    Content type: Short report

    Published on:

Annual Journal Metrics

  • Speed
    43 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    128 days from submission to acceptance
    24 days from acceptance to publication


    Citation Impact
    6.354 - 2-year Impact Factor
    5.230 - 5-year Impact Factor

    Usage
    460,369 downloads
    204 Altmetric mentions