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  1. Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims t...

    Authors: Lini Fang, Yang Tao, Guoying Che, Yongzi Yun, Min Ren and Yujie Liu
    Citation: Molecular Medicine 2024 30:31
  2. Sepsis is a systemic inflammatory response which is frequently associated with acute lung injury (ALI). Activating transcription factor 3 (ATF3) promotes M2 polarization, however, the biological effects of ATF...

    Authors: Wei Wang, Rongli Xu, Ping He, Yuqing Xiong, Haomiao Zhao, Xuewei Fu, Jie Lin and Lijiao Ye
    Citation: Molecular Medicine 2024 30:30
  3. The escalating challenge of Carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital-acquired pneumonia (HAP) is closely linked to the blaNDM-1 gene. This study explores the regulatory mechanisms of blaNDM-1...

    Authors: Liang Ding, Zheng Yang and Baier Sun
    Citation: Molecular Medicine 2024 30:29
  4. Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen depe...

    Authors: Jiaping Chen, Rong Zhao, Yangwei Wang, Han Xiao, Wei Lin, Mingxin Diao, Shiwen He, Peiyuan Mei and Yongde Liao
    Citation: Molecular Medicine 2024 30:28
  5. Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its effects on bone metabolism remain largely unknown.

    Authors: Bo Zhang, Zechao Qu, Hua Hui, Baorong He, Dong Wang, Yong Zhang, Yiwei Zhao, Jingjun Zhang and Liang Yan
    Citation: Molecular Medicine 2024 30:27
  6. Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oropharyngeal cancer in developed countries. HPV-related squamous cell carcinomas of the o...

    Authors: Robin Baudouin, Eric Tartour, Cécile Badoual and Stéphane Hans
    Citation: Molecular Medicine 2024 30:26
  7. Scleral extracellular matrix (ECM) remodeling plays a crucial role in the development of myopia, particularly in ocular axial elongation. Thrombospondin-1 (THBS1), also known as TSP-1, is a significant cellula...

    Authors: Junhan Chen, Shin-ichi Ikeda, Yajing Yang, Yan Zhang, Ziyan Ma, Yifan Liang, Kazuno Negishi, Kazuo Tsubota and Toshihide Kurihara
    Citation: Molecular Medicine 2024 30:25
  8. Lipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, eventually leading to severe retinal vascular abnormalities. Selenium (Se) can directly or ...

    Authors: Tian Niu, Xin Shi, Xijian Liu, Haiyan Wang, Kun Liu and Yupeng Xu
    Citation: Molecular Medicine 2024 30:24
  9. Fluvoxamine is one of the selective serotonin reuptake inhibitors (SSRIs) that are regarded as the first-line drugs to manage mental disorders. It has been also recognized with the potential to treat inflammat...

    Authors: Yuan Zou, Jing Zhang, Fei Sun, Qianqian Xu, Longmin Chen, Xi Luo, Ting Wang, Qing Zhou, Shu Zhang, Fei Xiong, Wen Kong, Ping Yang, Qilin Yu, Shiwei Liu and Cong-Yi Wang
    Citation: Molecular Medicine 2024 30:23
  10. The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory refl...

    Authors: Mabel N. Abraham, Ana Nedeljkovic-Kurepa, Tiago D. Fernandes, Omar Yaipen, Mariana R. Brewer, Daniel E. Leisman, Matthew D. Taylor and Clifford S. Deutschman
    Citation: Molecular Medicine 2024 30:22
  11. Pericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic ...

    Authors: Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki and Toshiyasu Sasaoka
    Citation: Molecular Medicine 2024 30:21
  12. Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability. The main patholo...

    Authors: Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang and Huanghe Yu
    Citation: Molecular Medicine 2024 30:20
  13. Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be suitable for active surveillance. We previously deve...

    Authors: Michael Rade, Markus Kreuz, Angelika Borkowetz, Ulrich Sommer, Conny Blumert, Susanne Füssel, Catharina Bertram, Dennis Löffler, Dominik J. Otto, Livia A. Wöller, Carolin Schimmelpfennig, Ulrike Köhl, Ann-Cathrin Gottschling, Pia Hönscheid, Gustavo B. Baretton, Manfred Wirth…
    Citation: Molecular Medicine 2024 30:19
  14. Ischemia–reperfusion (I/R) injury is a major cause of surgical skin flap compromise and organ dysfunction. Platelet-rich plasma (PRP) is an autologous product rich in growth factors, with tissue regenerative p...

    Authors: Linlin Su, Songtao Xie, Ting Li, Yanhui Jia and Yunchuan Wang
    Citation: Molecular Medicine 2024 30:18
  15. It is well-established that CD8+ T-cells play a critical role in graft rejection. The basic leucine zipper ATF-like transcription factor (BATF) and BATF3 are transcriptional factors expressed in T lymphocytes. He...

    Authors: Chenghao Li, Zongtao Liu, Zihao Wang, Wai Yen Yim, Yajun Huang and Yuqi Chen
    Citation: Molecular Medicine 2024 30:16
  16. In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity and aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated my...

    Authors: Hao Yu, Daojing Gan, Zhen Luo, Qilin Yang, Dongqi An, Hao Zhang, Yingchun Hu, Zhuang Ma, Qingchun Zeng, Dingli Xu and Hao Ren
    Citation: Molecular Medicine 2024 30:15
  17. N6-Methyladenosine (m6A) methylation is the most prevalent post-transcriptional modification in mRNA, and plays significant roles in various diseases. Nevertheless, the precise functions of m6A modification in...

    Authors: Chenzhen Xu, Congkuan Song, Wenjie Wang, Bohao Liu, Guorui Li, Tinglv Fu, Bo Hao, Ning Li and Qing Geng
    Citation: Molecular Medicine 2024 30:14
  18. PD-1/PD-L1 play a crucial role as immune checkpoint inhibitors in various types of cancer. Although our previous study revealed that NPM1 was a novel transcriptional regulator of PD-L1 and stimulated the trans...

    Authors: Ge Qin, Fan Bai, Huabin Hu, Jianwei Zhang, Weixiang Zhan, Zehua Wu, Jianxia Li, Yang Fu and Yanhong Deng
    Citation: Molecular Medicine 2024 30:13
  19. Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution.

    Authors: Giulio Ferrero, Rosaria Festa, Laura Follia, Gennaro Lettieri, Sonia Tarallo, Tiziana Notari, Antonella Giarra, Carmela Marinaro, Barbara Pardini, Alessandra Marano, Giulia Piaggeschi, Carla Di Battista, Marco Trifuoggi, Marina Piscopo, Luigi Montano and Alessio Naccarati
    Citation: Molecular Medicine 2024 30:12
  20. Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline...

    Authors: Di-Zheng Wu, Guo-Zheng Zhu, Kai Zhao, Jia-Wen Gao, Gui-Xing Cai, Hong-Zhou Li, Yu-Sheng Huang, Chen Tu, Jing-Shen Zhuang, Zhi-Wei Huang and Zhao-Ming Zhong
    Citation: Molecular Medicine 2024 30:10
  21. Lysine demethylase 5C (KDM5C) has been implicated in the development of several human cancers. This study aims to investigate the role of KDM5C in the progression of colorectal cancer (CRC) and explore the ass...

    Authors: Fulong Yu, Liang Li, Yimei Gu, Song Wang, Lianbang Zhou, Xiaohu Cheng, Heng Jiang, Yang Huang, Yingfeng Zhang, Wenbao Qian, Xianghua Li and Zhining Liu
    Citation: Molecular Medicine 2024 30:9
  22. Medial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life quality of patients. This study aimed to investigate the effects of prote...

    Authors: Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao and Guangyi Zhao
    Citation: Molecular Medicine 2024 30:8
  23. Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the nor...

    Authors: Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang and Liang Xiao
    Citation: Molecular Medicine 2024 30:7
  24. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm infants, characterised by compromised alveolar development and pulmonary vascular abnormalities. Emerging evidence suggests that reg...

    Authors: Ying Zhu, Langyue He, Yue Zhu, Huici Yao, Jianfeng Jiang and Hongyan Lu
    Citation: Molecular Medicine 2024 30:6
  25. Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to in...

    Authors: Ziang Zheng, Xinghan Zhao, Bo Yuan, Shan Jiang, Rushan Yan, Xiaowei Dong, Qijun Yao and Haidong Liang
    Citation: Molecular Medicine 2024 30:5
  26. Autophagic defects are involved in Methamphetamine (Meth)-induced neurotoxicity. Syntaxin 17 (Stx17), a member of the SNARE protein family, participating in several stages of autophagy, including autophagosome...

    Authors: Xi Wang, Miaoyang Hu, Jingrong Chen, Xinyu Lou, Hongchao Zhang, Muhan Li, Jie Cheng, Tengfei Ma, Jianping Xiong, Rong Gao, Xufeng Chen and Jun Wang
    Citation: Molecular Medicine 2024 30:4
  27. Lesch-Nyhan disease (LND) is a severe neurological disorder caused by the genetic deficiency of hypoxanthine–guanine phosphoribosyltransferase (HGprt), an enzyme involved in the salvage synthesis of purines. T...

    Authors: Paula Escudero-Ferruz, Neus Ontiveros, Claudia Cano-Estrada, Diane J. Sutcliffe, H. A. Jinnah, Rosa J. Torres and José M. López
    Citation: Molecular Medicine 2024 30:3
  28. Umbilical cord blood-derived therapeutics, such as serum (UCS) and platelet-rich plasma (UCPRP), are popular treatment options in clinical trials and can potentially be utilized to address a clinically unmet n...

    Authors: Ruojing Huang, Caiying Su, Na Zhang, Congying Shi, Guangming Pu, Yong Ding, Wei Wei and Jiansu Chen
    Citation: Molecular Medicine 2024 30:2
  29. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals a...

    Authors: Kaylin Huitsing, Tara Tritsch, Francisco Javier Carrera Arias, Fanny Collado, Kristina K. Aenlle, Lubov Nathason, Mary Ann Fletcher, Nancy G. Klimas and Travis J. A. Craddock
    Citation: Molecular Medicine 2024 30:1
  30. Sepsis is a severe syndrome of organ dysfunction that often leads to cardiac dysfunction and endangers life. The role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) in LPS-induced myocardial injury is uncle...

    Authors: Haoran Liu, Qin Hu, Ke Ren, Pengxin Wu, Yang Wang and Chuanzhu Lv
    Citation: Molecular Medicine 2023 29:171
  31. T cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) initially discovered on the surface of Th1 cells, negatively regulates immune responses and mediates apoptosis of Th1 cells. An increasing n...

    Authors: Wei Tian, Min Liu, Yuqiu Liu, Qingfeng Lv, HuaFeng Cheng, Yanling Gu and Mingjiang Li
    Citation: Molecular Medicine 2023 29:170
  32. The aberrant formation of neutrophil extracellular traps (NETs) has been implicated in ulcerative colitis (UC), a chronic recurrent intestinal inflammation. Cyclosporine A (CsA) is now applied as rescue therap...

    Authors: Chenjing Xu, Ziping Ye, Wenyu Jiang, Shu Wang and Hongjie Zhang
    Citation: Molecular Medicine 2023 29:169
  33. Shenqi Compound (SQC) has been used in clinic for several decades in the prevention and treatment of diabetes and its complications. But this is merely a heritage of experience. The primary aim of this study i...

    Authors: Chan Yang, Ziyan Xie, Hanyu Liu, Xueru Wang, Zehua Zhang, Lian Du and Chunguang Xie
    Citation: Molecular Medicine 2023 29:168
  34. The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING si...

    Authors: Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu…
    Citation: Molecular Medicine 2023 29:167
  35. Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after int...

    Authors: Runfeng Wang, Jin Wang, Zhiguo Zhang, Bo Ma, Shukai Sun, Li Gao and Guodong Gao
    Citation: Molecular Medicine 2023 29:165
  36. Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be rel...

    Authors: Ziyue Zhang, Xingbing Li, Jingwen Guo, Bo He, Lianpan Wu, Rongpei Yang, Xingyue Li, Dandong Fang, XiaoLi Yang, Donghai Yang, Fengxian Wang, Ming Tang, Yu Han, Pedro A. Jose, Hongyong Wang and Chunyu Zeng
    Citation: Molecular Medicine 2023 29:164
  37. Acute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, and mortality rates remain high. There are well established sex differences in renal IR, ...

    Authors: Riyaz Mohamed and Jennifer C. Sullivan
    Citation: Molecular Medicine 2023 29:163
  38. Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease and worsens its prognosis. Insulin-like growth factor 2 (IGF2) has been implicated in nu...

    Authors: Xiaohai Zhou, Bowen Tan, Weiwei Gui, Caiping Zhou, Hanxin Zhao, Xihua Lin and Hong Li
    Citation: Molecular Medicine 2023 29:161
  39. Anxiety and depression-like behaviors in allergic rhinitis (AR) are attracting attention, while the precise mechanism has not been clearly elucidated. Recent evidence shows that neuroinflammation in anterior c...

    Authors: Ziang Gao, Hao Lv, Yunfei Wang, Yulie Xie, Mengting Guan and Yu Xu
    Citation: Molecular Medicine 2023 29:160
  40. Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute respiratory distress syndrome (ARDS). However, the interaction between Doublecortin-lik...

    Authors: Xiao-Yue Chen, Ching Kao, Syue-Wei Peng, Jer-Hwa Chang, Yueh-Lun Lee, Vincent Laiman, Kian Fan Chung, Pankaj K. Bhavsar, Didik Setyo Heriyanto, Kai-Jen Chuang and Hsiao-Chi Chuang
    Citation: Molecular Medicine 2023 29:159
  41. Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflammatory activity in the context of several inflammatory diseases. A previous study reported that MaR1 could suppress MSU crystal-i...

    Authors: Hui Jiang, DianZe Song, Xiaoqin Zhou, Feng Chen, Qingqing Yu, Long Ren, Qian Dai and Mei Zeng
    Citation: Molecular Medicine 2023 29:158
  42. Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The role of USP38, a member of the ubiquitin-specific protease family, on MI-induced atria...

    Authors: Yang Gong, Tingting Yu, Wei Shuai, Tao Chen, Jingjing Zhang and He Huang
    Citation: Molecular Medicine 2023 29:157
  43. Krüppel-like factor 10 (KLF10) is involved in a positive feedback loop that regulates transforming growth factor β (TGFβ) signaling, and TGFβ plays an important role in the pathogenesis of liver disease. Here,...

    Authors: Sung Hwan Yoo, Ji Hae Nahm, Woon Kyu Lee, Hyun Woong Lee, Hye Young Chang and Jung Il Lee
    Citation: Molecular Medicine 2023 29:156
  44. Colorectal cancer (CRC) is the third frequently diagnosed cancer with high incidence and mortality rate worldwide. Our previous report has demonstrated that circCOL1A1 (hsa_circ_0044556) functions as an oncoge...

    Authors: Gui Hu, Changwei Lin, Kai Gao, Miao Chen, Fei Long and Buning Tian
    Citation: Molecular Medicine 2023 29:155
  45. Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. ...

    Authors: Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang and Jinhua Shen
    Citation: Molecular Medicine 2023 29:154
  46. The MeltPro TB assay (MeltPro) is a molecular rapid diagnostic test designed for detecting resistance to antituberculosis drugs. However, the performance of MeltPro as an initial diagnostic test for simultaneo...

    Authors: Zhi-bin Liu, Li-ping Cheng, Hong-qiu Pan, Xiao-cui Wu, Fu-hui Lu, Jie Cao, Lei Wang, Wei Wei, Hong-yu Chen, Wei Sha and Qin Sun
    Citation: Molecular Medicine 2023 29:153

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