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  1. Increasing evidence has indicated that circular RNAs (circRNAs) play a role in various diseases. However, the influence of circRNAs in nephritis remains unknown.

    Authors: Peng-Wei Guo, Hai-Ting Huang, Jing Ma, Yao Zuo, Dan Huang, Lin-Lin He, Zi-Ming Wan, Cheng Chen, Fa-Fen Yang and Yan-Wu You

    Citation: Molecular Medicine 2021 27:113

    Content type: Research article

    Published on:

  2. The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology’s ability to investigate and respond to a novel pathogen and modern medicine’s ability to marshal effective fron...

    Authors: Douglas F. Nixon, Daniela Marín-Hernández and Nathaniel Hupert

    Citation: Molecular Medicine 2021 27:112

    Content type: Perspective

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  3. Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6), a unique histone deacetylase with two functional catalytic d...

    Authors: Ping Liu, Ji Xiao, Yiliang Wang, Xiaowei Song, Lianzhou Huang, Zhe Ren, Kaio Kitazato and Yifei Wang

    Citation: Molecular Medicine 2021 27:110

    Content type: Review

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  4. Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-214 is possibly implicated in bronchopulmonary dysplasia (BPD) have not ...

    Authors: Zhi-Qun Zhang, Hui Hong, Jing Li, Xiao-Xia Li and Xian-Mei Huang

    Citation: Molecular Medicine 2021 27:109

    Content type: Research article

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  5. Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism...

    Authors: Sofia Moran-Ramos, Luis Macias-Kauffer, Blanca E. López-Contreras, Hugo Villamil-Ramírez, Elvira Ocampo-Medina, Paola León-Mimila, Blanca E. del Rio-Navarro, Omar Granados-Portillo, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Armando R. Tovar, Nimbe Torres, Francisco J. Gomez-Perez, Carlos Aguilar-Salinas and Samuel Canizales-Quinteros

    Citation: Molecular Medicine 2021 27:108

    Content type: Research article

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  6. Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial...

    Authors: Rodrigo R. R. Duarte, Dennis C. Copertino Jr., Luis P. Iñiguez, Jez L. Marston, Yaron Bram, Yuling Han, Robert E. Schwartz, Shuibing Chen, Douglas F. Nixon and Timothy R. Powell

    Citation: Molecular Medicine 2021 27:105

    Content type: Research article

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  7. Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis). However, recent an...

    Authors: Liang Shan, Ximing Xu, Jing Zhang, Peng Cai, Han Gao, Yingjie Lu, Jiangang Shi, Yinlong Guo and Yue Su

    Citation: Molecular Medicine 2021 27:103

    Content type: Research article

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  8. The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be c...

    Authors: Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara and Kenneth R. Chien

    Citation: Molecular Medicine 2021 27:102

    Content type: Short report

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  9. Diet-induced obesity can result in the development of a diverse spectrum of cardiovascular and metabolic diseases, including type 2 diabetes, dyslipidemia, non-alcoholic liver steatosis and atherosclerotic dis...

    Authors: Christian Smolka, Delia Schlösser, Catherine Hohnloser, Xavier Bemtgen, Caterina Jänich, Laura Schneider, Julien Martin, Dietmar Pfeifer, Martin Moser, Peter Hasselblatt, Christoph Bode, Sebastian Grundmann and Franziska Pankratz

    Citation: Molecular Medicine 2021 27:101

    Content type: Research article

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  10. Oxidative stress is an important factor involved in the progress of heart failure. The current study was performed to investigate whether pinocembrin was able to ameliorate post-infarct heart failure (PIHF) an...

    Authors: Xiuhuan Chen, Weiguo Wan, Yan Guo, Tianxin Ye, Yuhong Fo, Yazhou Sun, Chuan Qu, Bo Yang and Cui Zhang

    Citation: Molecular Medicine 2021 27:100

    Content type: Research article

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  11. We have found disruption of expression of major transcriptional regulators of circadian rhythm in the kidneys of several mouse models of lupus nephritis. Here we define the consequence of this disturbance with...

    Authors: Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang and Anne Davidson

    Citation: Molecular Medicine 2021 27:99

    Content type: Research article

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  12. Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell

    Citation: Molecular Medicine 2021 27:98

    Content type: Correction

    Published on:

    The original article was published in Molecular Medicine 2021 27:79

  13. N-Acetylcysteine (NAC) demonstrates applications in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD). COPD is often characterized by fibrosis of the small airways. This study aims .....

    Authors: Lanlan Zhu, Fei Xu, Xiuhua Kang, Jing Zhou, Qinqin Yao, Yang Lin and Wei Zhang

    Citation: Molecular Medicine 2021 27:97

    Content type: Research article

    Published on:

  14. Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction m...

    Authors: Yi Sun, Ping Leng, Pengcheng Guo, Huanshen Gao, Yikai Liu, Chenkai Li, Zhenghui Li and Haining Zhang

    Citation: Molecular Medicine 2021 27:96

    Content type: Research article

    Published on:

  15. Long noncoding RNAs (lncRNAs), a type of pervasive genes that regulates various biological processes, are differentially expressed in different types of malignant tumors. The role of lncRNAs in the carcinogene...

    Authors: Jinglei Li, Hanxing Tong, Dongping Li, Qiuyu Jiang, Yong Zhang, Wenqing Tang, Dayong Jin, She Chen, Xinyu Qin, Si Zhang and Ruyi Xue

    Citation: Molecular Medicine 2021 27:95

    Content type: Research article

    Published on:

  16. Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently closed circular structure resulting from pre-mRNA back splicing via spliceosome and ribozymes. They can be classified diffe...

    Authors: Mei Tao, Ming Zheng, Yanhua Xu, Shuo Ma, Weiwei Zhang and Shaoqing Ju

    Citation: Molecular Medicine 2021 27:94

    Content type: Review

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  17. Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes of intervertebral disc (IVD) degeneration (IVDD). The pathogenesis of IVDD is complex and consists of inflammation, oxidat...

    Authors: Xiaoqiang Cheng, Jiayi Lin, Zhanghuan Chen, Yubo Mao, Xiexin Wu, Congxin Xu, Jiacheng Du, Zhongchen Dong, Huilin Yang, Feng Zhou and Dechun Geng

    Citation: Molecular Medicine 2021 27:92

    Content type: Research article

    Published on:

  18. Intervertebral disc degeneration (IVDD) is the breakdown of the discs supporting the vertebrae. It is one of the most frequent causes of back pain worldwide. Currently, the clinical interventions for IVDD are ...

    Authors: Xiaoqiu Yuan, Tiefeng Li, Lei Shi, Jinhao Miao, Yongfei Guo and Yu Chen

    Citation: Molecular Medicine 2021 27:91

    Content type: Research article

    Published on:

  19. It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are increased in patients after myocardial infarction (MI). However, whether g...

    Authors: Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue and Lin Cai

    Citation: Molecular Medicine 2021 27:90

    Content type: Research article

    Published on:

  20. Atherosclerosis is recognized as a chronic immuno-inflammatory disease that is characterized by the accumulation of immune cells and lipids in the vascular wall. In this review, we focus on the latest advance ...

    Authors: Jin-Wen Luo, Yuan Hu, Jian Liu, Huan Yang and Peng Huang

    Citation: Molecular Medicine 2021 27:88

    Content type: Review

    Published on:

  21. Tongue squamous cell carcinoma (TSCC) ranks as the most prevalent malignancy in the oral cavity. TSCC patients with occult lymph node metastasis (OLNM) are thought to be at risk of worse outcome. However, regu...

    Authors: Bo Zhou, Yue Zhou, Ying Liu, Hailin Zhang, Huangxing Mao, Mingjing Peng, Anji Xu, Zan Li, Hui Wang, Haolei Tan, Huayi Ren, Xiao Zhou and Ying Long

    Citation: Molecular Medicine 2021 27:85

    Content type: Research article

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  22. Fetal docosahexaenoic acid (DHA) supply relies on preferential transplacental transfer, which is regulated by placental DHA lipid metabolism. Maternal hyperglycemia and obesity associate with higher birthweigh...

    Authors: Oliver C. Watkins, Preben Selvam, Reshma Appukuttan Pillai, Victoria K. B. Cracknell-Hazra, Hannah E. J. Yong, Neha Sharma, Amaury Cazenave-Gassiot, Anne K. Bendt, Keith M. Godfrey, Rohan M. Lewis, Markus R. Wenk and Shiao-Yng Chan

    Citation: Molecular Medicine 2021 27:84

    Content type: Research article

    Published on:

  23. Heterogeneity in colorectal cancer (CRC) patients provides novel strategies in clinical decision-making. Identifying distinctive subgroups in patients can improve the screening of CRC and reduce the cost of te...

    Authors: Yongqu Lu, Wendong Wang, Zhenzhen Liu, Junren Ma, Xin Zhou and Wei Fu

    Citation: Molecular Medicine 2021 27:83

    Content type: Research article

    Published on:

  24. Numerous studies have confirmed the correlation of microRNAs (miRNAs) with human disease, yet few have explored the role of miR-135 in preeclampsia (PE). This study intends to discuss miR-135’s function in inf...

    Authors: Xiaolan Zhao, Xun Zhang, Zhao Wu, Jie Mei, Lingling Li and Yujue Wang

    Citation: Molecular Medicine 2021 27:82

    Content type: Research article

    Published on:

  25. Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by in...

    Authors: Yu Fu, Zhili Xin, Ziji Ling, Hanyu Xie, Tao Xiao, Xin Shen, Jialin Lin, Ling Xu and Hongbing Jiang

    Citation: Molecular Medicine 2021 27:81

    Content type: Research article

    Published on:

  26. Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models. This study aimed to ...

    Authors: Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen and Wubing He

    Citation: Molecular Medicine 2021 27:80

    Content type: Research article

    Published on:

  27. High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the cleara...

    Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell

    Citation: Molecular Medicine 2021 27:79

    Content type: Research article

    Published on:

    The Correction to this article has been published in Molecular Medicine 2021 27:98

  28. Extracellular vesicles (EVs) derived from tumor cells are implicated in the progression of malignancies through the transfer of molecular cargo microRNAs (miRNAs or miRs). We aimed to explore the role of EVs d...

    Authors: Chong Lu, Yu Zhao, Jing Wang, Wei Shi, Fang Dong, Yue Xin, Xiangwang Zhao and Chunping Liu

    Citation: Molecular Medicine 2021 27:78

    Content type: Research article

    Published on:

  29. Propofol, an intravenous anesthetic, was proven to protect against lung ischemia/reperfusion (I/R) injury. However, the detailed mechanism of Propofol in lung I/R injury is still elusive. This study was design...

    Authors: Jian-Ping Zhang, Wei-Jing Zhang, Miao Yang and Hua Fang

    Citation: Molecular Medicine 2021 27:77

    Content type: Research article

    Published on:

  30. Tuberculosis (TB) is an infectious disease. During TB, regulatory T cells (Treg) are related to poor prognosis. However, information about conventional and unconventional Treg (cTreg and uTreg, respectively) i...

    Authors: Norma A. Téllez-Navarrete, Lucero A. Ramon-Luing, Marcela Muñoz-Torrico, Mario Preciado-García, Karen Medina-Quero, Rogelio Hernandez-Pando and Leslie Chavez-Galan

    Citation: Molecular Medicine 2021 27:76

    Content type: Research article

    Published on:

  31. Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a cruci...

    Authors: Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu and Changhong Miao

    Citation: Molecular Medicine 2021 27:74

    Content type: Research article

    Published on:

  32. Although miR-125b plays a crucial role in many human cancers. However, its function in heart failure (HF) remains unclear. Our study aimed to investigate its involvement in heart failure.

    Authors: Bei Zhang, Shanyong Mao, Xingde Liu, Sha Li, Haiyan Zhou, Ying Gu, Wupeng Liu, Lei Fu, Chunyan Liao and Pengzhen Wang

    Citation: Molecular Medicine 2021 27:72

    Content type: Research article

    Published on:

  33. Maternally Expressed Gene 3 (MEG3) is expressed at low levels in placental villi during preeclampsia; however, its roles in unexplained recurrent spontaneous abortion (URSA) remain unclear. In this study, we aime...

    Authors: Jun Zhang, Xinqiong Liu and Yali Gao

    Citation: Molecular Medicine 2021 27:70

    Content type: Research article

    Published on:

  34. Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17) express...

    Authors: Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin and Bing-Chang Chen

    Citation: Molecular Medicine 2021 27:69

    Content type: Research article

    Published on:

  35. The aim of this study was to investigate the clinical value of liquid biopsy as a primary source for variant analysis in lung cancer. In addition, we sought to characterize liquid biopsy variants and to correl...

    Authors: Alvida Qvick, Bianca Stenmark, Jessica Carlsson, Johan Isaksson, Christina Karlsson and Gisela Helenius

    Citation: Molecular Medicine 2021 27:68

    Content type: Research article

    Published on:

  36. This study aimed to explore the role of mesenchymal stromal cells (MSCs)-derived exosomes (MSCs-Exo) in the cerebral ischemia–reperfusion (I/R) injury.

    Authors: Chang Cheng, Xiuying Chen, Yuhan Wang, Wenchao Cheng, Xuzheng Zuo, Weiju Tang and Wen Huang

    Citation: Molecular Medicine 2021 27:67

    Content type: Research article

    Published on:

  37. Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activat...

    Authors: Haijun Zhao, Weijie Zhu, Wude Mao and Chengkai Shen

    Citation: Molecular Medicine 2021 27:66

    Content type: Research article

    Published on:

  38. Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response.

    Authors: Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar and Yoram Vodovotz

    Citation: Molecular Medicine 2021 27:65

    Content type: Research article

    Published on:

  39. The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).

    Authors: Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li and Zhiwen Zhang

    Citation: Molecular Medicine 2021 27:64

    Content type: Research article

    Published on:

Annual Journal Metrics

  • Speed
    43 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    128 days from submission to acceptance
    24 days from acceptance to publication


    Citation Impact
    6.354 - 2-year Impact Factor
    5.230 - 5-year Impact Factor

    Usage
    460,369 downloads
    204 Altmetric mentions