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  1. Content type: Research article

    Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the...

    Authors: Wen-Chih Chiang, Yu-Chin Huang, Ten-I Fu, Ping-Min Chen, Fan-Chi Chang, Chun-Fu Lai, Vin-Cent Wu, Shuei-Liong Lin and Yung-Ming Chen

    Citation: Molecular Medicine 2019 25:5

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  2. Content type: Research article

    Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible ...

    Authors: Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll and Alex F. de Vos

    Citation: Molecular Medicine 2019 25:3

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  3. Content type: Research article

    Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Here, we sought to investigate the glucose metabolism characteristics of SUR1−/− rats.

    Authors: Xiaojun Zhou, Chunmei Xu, Zhiwei Zou, Xue Shen, Tianyue Xie, Rui Zhang, Lin Liao and Jianjun Dong

    Citation: Molecular Medicine 2019 25:2

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  4. Content type: Research article

    Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to invest...

    Authors: Rose A. Willemze, Olaf Welting, Patricia van Hamersveld, Caroline Verseijden, Laurens E. Nijhuis, Francisca W. Hilbers, Sybren L. Meijer, Balthasar A. Heesters, Joost H. A. Folgering, Harold Darwinkel, Philippe Blancou, Margriet J. Vervoordeldonk, Jurgen Seppen, Sigrid E. M. Heinsbroek and Wouter J. de Jonge

    Citation: Molecular Medicine 2019 25:1

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  5. Content type: Research

    Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate c...

    Authors: Yiting Tang, Rui Zhang, Qianqian Xue, Ran Meng, Xiangyu Wang, Yanliang Yang, Lingli Xie, Xianzhong Xiao, Timothy R. Billiar and Ben Lu

    Citation: Molecular Medicine 2018 24:66

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  6. Content type: Research article

    Numerous host cellular factors are exploited by viruses to facilitate infection. Our previous studies and those of others have shown heat-shock protein 90 (Hsp90), a cellular molecular chaperone, is involved i...

    Authors: Yiliang Wang, Rongze Wang, Feng Li, Yun Wang, Zhen Zhang, Qiaoli Wang, Zhe Ren, Fujun Jin, Kaio Kitazato and Yifei Wang

    Citation: Molecular Medicine 2018 24:65

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  7. Content type: Research article

    The multiple biological effects of vitamin D and its novel activities on inflammation and redox homeostasis have raised high expectations on its use as a therapeutic agent for multiple fibrogenic conditions. W...

    Authors: Trinidad Guijarro, Esmeralda Magro-Lopez, Joana Manso, Ricardo Garcia-Martinez, Maria Jesus Fernandez-Aceñero, Isabel Liste and Alberto Zambrano

    Citation: Molecular Medicine 2018 24:64

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  8. Content type: Research article

    Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought t...

    Authors: Rafael Y. Brzezinski, Eyal Fisher, Noa Cohen, Etti Zwang, Gabi Shefer, Naftali Stern, David Zeltser, Itzhak Shapira, Shlomo Berliner, Ori Rogowski and Shani Shenhar-Tsarfaty

    Citation: Molecular Medicine 2018 24:63

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  9. Content type: Research article

    Gold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown. The aim of this study is to explore the effect of AuN...

    Authors: Hui Yang, Libo Du, Guangjun Wu, Zhenyu Wu and Jeffrey A. Keelan

    Citation: Molecular Medicine 2018 24:62

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  10. Content type: Research article

    There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD)...

    Authors: Yue Dong, Li-Li Han and Zhong-Xin Xu

    Citation: Molecular Medicine 2018 24:61

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  11. Content type: Research article

    We tested the hypothesis that extracorporeal shockwave treatment (ESWT) can abolish inflammation and restore urothelial barrier integrity in acute interstitial cystitis by upregulating the fatty acid receptor ...

    Authors: Yi-Ling Chen, Yuan-Ping Lin, Cheuk-Kwan Sun, Tien-Hung Huang, Hon-Kan Yip and Yen-Ta Chen

    Citation: Molecular Medicine 2018 24:60

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  12. Content type: Review

    Traditional risk factors are insufficient to explain all cases of coronary artery disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products (AGEs) and their receptors may play impo...

    Authors: Sarah Louise Fishman, Halis Sonmez, Craig Basman, Varinder Singh and Leonid Poretsky

    Citation: Molecular Medicine 2018 24:59

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  13. Content type: Research article

    The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion (I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective mechanisms of PPF were linked to its reg...

    Authors: Bei Sun, Hao Ou, Fei Ren, Ye Huan, Tao Zhong, Min Gao and Hongwei Cai

    Citation: Molecular Medicine 2018 24:58

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  14. Content type: Research article

    Gene expression profiles of normal and tumor tissue reflect both differences in biological processes taking place in vivo and differences in response to stress during surgery and sample handling. The effect of...

    Authors: Inge Søkilde Pedersen, Mads Thomassen, Qihua Tan, Torben Kruse, Ole Thorlacius-Ussing, Jens Peter Garne and Henrik Bygum Krarup

    Citation: Molecular Medicine 2018 24:57

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  15. Content type: Research article

    Exposure of rodents to chronic high-fat diet (HFD) results in upregulation of inflammatory markers and proliferation of microglia within the mediobasal hypothalamus. Such hypothalamic inflammation is associate...

    Authors: Mary K. Herrick, Kristin M. Favela, Richard B. Simerly, Naji N. Abumrad and Nathan C. Bingham

    Citation: Molecular Medicine 2018 24:56

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  16. Content type: Research article

    Intestinal barrier dysfunction is a significant clinical problem, commonly developing in a variety of acute or chronic pathological conditions. Herein, we evaluate the effect of microRNA-31 (miR-31) on intesti...

    Authors: Cheng-Ye Zhan, Di Chen, Jin-Long Luo, Ying-Hua Shi and You-Ping Zhang

    Citation: Molecular Medicine 2018 24:55

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  17. Content type: Research article

    Currently, no suitable clinical marker for detection of septic immunosuppression is available. We aimed at identifying microRNAs that could serve as biomarkers of T-cell mediated immunoparalysis in sepsis.

    Authors: P Möhnle, S Hirschberger, L C Hinske, J Briegel, M Hübner, S Weis, G Dimopoulos, M Bauer, E J Giamarellos-Bourboulis and S Kreth

    Citation: Molecular Medicine 2018 24:54

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  18. Content type: Research article

    Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum level...

    Authors: Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran and Ziv Ben-Ari

    Citation: Molecular Medicine 2018 24:53

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  19. Content type: Research article

    For the study, we determine the potential biomarkers and uncover the regulatory mechanisms of lncRNA MALAT1 / miR-145 / SOX9 axis on the abilities of cell growth and cell metastasis of colorectal cancer.

    Authors: Yuanlin Xu, Xihong Zhang, Xiufeng Hu, Wenping Zhou, Peipei Zhang, Jiuyang Zhang, Shujun Yang and Yanyan Liu

    Citation: Molecular Medicine 2018 24:52

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  20. Content type: Research article

    The pro-myelinating effects of leukemia inhibitory factor (LIF) and other cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), have long been known, but controver...

    Authors: Georgina Gyetvai, Cieron Roe, Lamia Heikal, Pietro Ghezzi and Manuela Mengozzi

    Citation: Molecular Medicine 2018 24:51

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  21. Content type: Research article

    MicroRNAs (miRNAs) contribute to the progression of chronic kidney disease (CKD) by regulating renal homeostasis. This study explored the effects of miR-181a on CKD through the Toll-like receptor (TLR)/nuclear...

    Authors: Lei Liu, Xin-Lu Pang, Wen-Jun Shang, Hong-Chang Xie, Jun-Xiang Wang and Gui-Wen Feng

    Citation: Molecular Medicine 2018 24:49

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  22. Content type: Research article

    Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal deformity. The etiology and pathology of AIS remain unexplained, and have been reported to involve a combination of genetic and epigen...

    Authors: Heng Jiang, Fu Yang, Tao Lin, Wei Shao, Yichen Meng, Jun Ma, Ce Wang, Rui Gao and Xuhui Zhou

    Citation: Molecular Medicine 2018 24:48

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  23. Content type: Research article

    Sulfonylureas (SUs) are widely prescribed for the treatment of type 2 diabetes (T2DM). Sulfonylurea receptors (SURs) are their main functional receptors. These receptors are also found in kidney, especially th...

    Authors: Rui Zhang, Xiaojun Zhou, Xue Shen, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong and Lin Liao

    Citation: Molecular Medicine 2018 24:47

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  24. Content type: Review

    Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are small (104 amino acids) and have a striking relationship to the acute phase response with serum levels rising as much as 1000-...

    Authors: George H. Sack Jr

    Citation: Molecular Medicine 2018 24:46

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  25. Content type: Short report

    Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of c...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Molecular Medicine 2018 24:45

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  26. Content type: Research article

    Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune...

    Authors: Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Molecular Medicine 2018 24:44

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  27. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is characterized by pancreatic β-cell failure, which arises from metabolic stress and results in β cell dedifferentiation, leading to β-cell death. Pathological activation of th...

    Authors: Hong Chen, Wenjun Zhou, Yuting Ruan, Lei Yang, Ningning Xu, Rongping Chen, Rui Yang, Jia Sun and Zhen Zhang

    Citation: Molecular Medicine 2018 24:43

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  28. Content type: Research article

    Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disorder of the central nervous system (CNS). Several observations support interactions between vascular and neurodegenerative mechani...

    Authors: Giovanna Marchetti, Nicole Ziliotto, Silvia Meneghetti, Marcello Baroni, Barbara Lunghi, Erica Menegatti, Massimo Pedriali, Fabrizio Salvi, Ilaria Bartolomei, Sofia Straudi, Fabio Manfredini, Rebecca Voltan, Nino Basaglia, Francesco Mascoli, Paolo Zamboni and Francesco Bernardi

    Citation: Molecular Medicine 2018 24:42

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  29. Content type: Research Article

    Retinopathy of prematurity (ROP) remains a major cause of childhood blindness and current laser photocoagulation and anti-VEGF antibody treatments are associated with reduced peripheral vision and possible del...

    Authors: Rong Zhou, Shuya Zhang, Xuejiao Gu, Yuanyuan Ge, Dingjuan Zhong, Yuling Zhou, Lingyun Tang, Xiao-Ling Liu and Jiang-Fan Chen

    Citation: Molecular Medicine 2018 24:41

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  30. Content type: Research article

    This study aimed to investigate the effect of over-expressing circular RNA CEP128 (circCEP128) on cell functions and explore the molecular mechanism of which in bladder carcinoma.

    Authors: Zhun Wu, Wei Huang, Xuegang Wang, Tao Wang, Yuedong Chen, Bin Chen, Rongfu Liu, Peide Bai and Jinchun Xing

    Citation: Molecular Medicine 2018 24:40

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  31. Content type: Research article

    The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the heart by mimicking the cardioprotective effects of ischaemic postc...

    Authors: Fuhua Wang, Huan Wang, Xuejing Liu, Haiyi Yu, Bo Zuo, Zhu Song, Ning Wang, Wei Huang and Guisong Wang

    Citation: Molecular Medicine 2018 24:39

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  32. Content type: Research article

    Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic sec...

    Authors: Valentina Maria Sofia, Cecilia Surace, Vito Terlizzi, Letizia Da Sacco, Federico Alghisi, Antonella Angiolillo, Cesare Braggion, Natalia Cirilli, Carla Colombo, Antonella Di Lullo, Rita Padoan, Serena Quattrucci, Valeria Raia, Giuseppe Tuccio, Federica Zarrilli, Anna Cristina Tomaiuolo…

    Citation: Molecular Medicine 2018 24:38

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  33. Content type: Research article

    Histone deacetylases (HDACs) play a critical role in modulating myocardial protection and cardiomyocyte survivals. However, Specific HDAC isoforms in mediating myocardial ischemia/reperfusion injury remain cur...

    Authors: Ling Zhang, Hao Wang, Yu Zhao, Jianguo Wang, Patrycja M. Dubielecka, Shougang Zhuang, Gangjian Qin, Y Eugene Chin, Race L. Kao and Ting C. Zhao

    Citation: Molecular Medicine 2018 24:37

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  34. Content type: Research article

    This study was to examine the link between astrocyte elevated gene-1 (AEG-1) and hypoxia induced-chemoresistance in T-cell non-Hodgkin’s lymphoma (T-NHL), as well as the underlying molecular mechanisms.

    Authors: Jiaqin Yan, Junhui Zhang, Xudong Zhang, Xin Li, Ling Li, Zhaoming Li, Renyin Chen, Lei Zhang, Jingjing Wu, Xinhua Wang, Zhenchang Sun, Xiaorui Fu, Yu Chang, Feifei Nan, Hui Yu, Xiaolong Wu…

    Citation: Molecular Medicine 2018 24:35

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  35. Content type: Research article

    Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGF) receptor is a receptor tyrosine kinase, which may mediate signalling to promote progression an...

    Authors: Anna Mandel, Per Larsson, Martuza Sarwar, Julius Semenas, Azharuddin Sajid Syed Khaja and Jenny L. Persson

    Citation: Molecular Medicine 2018 24:34

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  36. Content type: Review

    Histone deacetylase 6 (HDAC6), a cytoplasmic enzyme that plays important roles in many biological processes, is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups fro...

    Authors: Ben Ke, Yanxia Chen, Wei Tu, Ting Ye, Xiangdong Fang and Liping Yang

    Citation: Molecular Medicine 2018 24:33

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  37. Content type: Research article

    Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiolog...

    Authors: Sean F. Monaghan, Debasree Banerjee, Chun-Shiang Chung, Joanne Lomas-Neira, Kamil J. Cygan, Christy L. Rhine, William G. Fairbrother, Daithi S. Heffernan, Mitchell M. Levy, William G. Cioffi and Alfred Ayala

    Citation: Molecular Medicine 2018 24:32

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  38. Content type: Correction

    After publication of this article (He et al., 2018), the corresponding authors recognised an error in Scheme 1, in particular to section “A. HMGB1/TLR4/MD-2 complex formation”. Above “Step 2: B box binding to ...

    Authors: Mingzhu He, Marco E. Bianchi, Tom R. Coleman, Kevin J. Tracey and Yousef Al-Abed

    Citation: Molecular Medicine 2018 24:31

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    The original article was published in Molecular Medicine 2018 24:21

  39. Content type: Research article

    Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined significance (MGUS) explicates genetic dependency of this asymptomatic precursor condition with multiple myel...

    Authors: Subhayan Chattopadhyay, Hauke Thomsen, Miguel Inacio da Silva Filho, Niels Weinhold, Per Hoffmann, Markus M. Nöthen, Arendt Marina, Karl-Heinz Jöckel, Börge Schmidt, Sonali Pechlivanis, Christian Langer, Hartmut Goldschmidt, Kari Hemminki and Asta Försti

    Citation: Molecular Medicine 2018 24:30

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  40. Content type: Research article

    Chronic autoimmune urticaria (CAU) is a common skin disease and remains unclear understanding of pathogenesis in the vast majority of cases. In order to explore a new therapy for CAU, the current study was per...

    Authors: Xiao-Yan Luo, Qun Liu, Huan Yang, Qi Tan, Li-Qiang Gan, Fa-Liang Ren and Hua Wang

    Citation: Molecular Medicine 2018 24:28

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  41. Content type: Research article

    Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3–4 fold greate...

    Authors: Jyotsna Bhattacharya, Karalyn Pappas, Bahtiyar Toz, Cynthia Aranow, Meggan Mackay, Peter K. Gregersen, Ogobara Doumbo, Abdel Kader Traore, Martin L. Lesser, Maureen McMahon, Tammy Utset, Earl Silverman, Deborah Levy, William J. McCune, Meenakshi Jolly, Daniel Wallace…

    Citation: Molecular Medicine 2018 24:24

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  42. Content type: Research article

    Parathyroid glands of people with relapsing remitting multiple sclerosis (RRMS) fail to respond to low serum 25-hydroxyvitamin D (25OHD) and low serum calcium, which are stimuli for parathyroid hormone (PTH) s...

    Authors: Mark Simon Stein, Gregory John Ward, Helmut Butzkueven, Trevor John Kilpatrick and Leonard Charles Harrison

    Citation: Molecular Medicine 2018 24:27

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  43. Content type: Research article

    Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and functionally unique sub-population of B cells, ...

    Authors: Monowar Aziz, Yasumasa Ode, Mian Zhou, Mahendar Ochani, Nichol E. Holodick, Thomas L. Rothstein and Ping Wang

    Citation: Molecular Medicine 2018 24:26

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  44. Content type: Review

    Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins. Translational readthrough of PTCs induce...

    Authors: Maciej Dabrowski, Zuzanna Bukowy-Bieryllo and Ewa Zietkiewicz

    Citation: Molecular Medicine 2018 24:25

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  45. Content type: Research article

    Stratified human keratinocytes (SHKs) are an essential part of mucosal innate immune response that modulates adaptive immunity to microbes encountered in the environment. The importance of these SHKs in mucosa...

    Authors: Mohd Israr, David Rosenthal, Lidia Frejo-Navarro, James DeVoti, Craig Meyers and Vincent R. Bonagura

    Citation: Molecular Medicine 2018 24:23

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  46. Content type: Research article

    Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional f...

    Authors: Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi and Gordon Ferns

    Citation: Molecular Medicine 2018 24:22

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