Articles

Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways

Dysfunctional osteogenesis of bone marrow mesenchymal stem cells (BMSCs) plays an important role in osteoporosis occurrence and development. However, the molecular mechanisms of osteogenic differentiation rema...

Authors: Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang and Minghai Wang

IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is r...

Authors: Qian Jin, He Yang, Zhao Jing, Wu Hong-hua, Song Ben-jing, Wang Li-ting, Ye Li-juan, Xu Wei, Kang Xia, Wu Juan and Zheng Wei

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19

We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortal...

Authors: Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu and Yongzhe Li

PIAS3 suppresses damage in an Alzheimer’s disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway

Alzheimer’s disease (AD), the most common form of dementia, is caused by the degeneration of the central nervous system (CNS). A previous study reported that signal transducer and activator of transcription 3 ...

Authors: Chen Li, Ruili Wang, Youyou Zhang, Chunting Hu and Qiaoya Ma

DMAG, a novel countermeasure for the treatment of thrombocytopenia

Thrombocytopenia is one of the most common hematological disease that can be life-threatening caused by bleeding complications. However, the treatment options for thrombocytopenia remain limited.

Authors: Jing Lin, Jing Zeng, Sha Liu, Xin Shen, Nan Jiang, Yue-Song Wu, Hong Li, Long Wang and Jian-Ming Wu

Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1

Imatinib (IM), targeting of BCR-ABL1 tyrosine kinase, is currently one of the first-line choices in the treatment of chronic myeloid leukemia (CML). This study aims to explore the molecular mechanisms underlyi...

Authors: Yao-hua Lu and Zhong-yi Huang

Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism

Patients with salt-sensitive hypertension are often accompanied with severe renal damage and accelerate to end-stage renal disease, which currently lacks effective treatment. Fibroblast growth factor 21 (FGF21...

Authors: Hua-Chun Weng, Xin-Yu Lu, Yu-Peng Xu, Yi-Hong Wang, Dan Wang, Yi-Ling Feng, Zhang Chi, Xiao-Qing Yan, Chao-Sheng Lu and Hong-Wei Wang

ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m⁶A modification to improve wound healing of diabetic foot ulcers

Adipose-derived mesenchymal stem cells (ADSCs) are an important focus in regenerative medicine. However, the biological function of ADSCs in the wound repair of diabetic foot ulcers (DFUs) remains unclear. Thi...

Authors: Jie Zhou, Tianhong Wei and Zhiyou He

Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes

The alarming trend of paediatric obesity deserves our greatest awareness to hinder the early onset of metabolic complications impacting growth and functionality. Presently, insight into molecular mechanisms of...

Authors: Margot De Spiegeleer, Ellen De Paepe, Lieven Van Meulebroek, Inge Gies, Jean De Schepper and Lynn Vanhaecke

Nuclear receptors: a bridge linking the gut microbiome and the host

The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological proc...

Authors: Zixuan Wang, Wei-Dong Chen and Yan-Dong Wang

LncRNA-ATB participates in the regulation of calcium oxalate crystal-induced renal injury by sponging the miR-200 family

LncRNA-ATB is a long noncoding RNA (lncRNA) activated by transforming growth factor β (TGF-β) and it has important biological functions in tumours and nontumour diseases. Meanwhile, TGF-β is the most critical ...

Authors: Yinhui Li, Tao Ding, Haiyan Hu, Tingting Zhao, Chao Zhu, Jiarong Ding, Jihang Yuan and Zhiyong Guo

Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network

Cardiotoxicity is a common complication following anthracycline chemotherapy and represents one of the serious adverse reactions affecting life, which severely limits the effective use of anthracyclines in can...

Authors: Guoxing Wan, Peinan Chen, Xue Sun, Xiaojun Cai, Xiongjie Yu, Xianhe Wang and Fengjun Cao

lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway

We aimed to investigate the functions and underlying mechanism of lncRNA SNHG1 in bone differentiation and angiogenesis in the development of osteoporosis.

Authors: Xiao Yu, Peng-Ze Rong, Meng-Sheng Song, Ze-Wen Shi, Gong Feng, Xian-Jun Chen, Lin Shi, Cheng-Hao Wang and Qing-Jiang Pang

Correction to: A Journey in Science: Immersion in the search for effective cancer immunotherapies

Authors: Steven A. Rosenberg

Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis

Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance in multiple solid tumours. However, there is a lack of universal measures of CAFs in c...

Authors: Yu-feng Chen, Zhao-liang Yu, Min-yi Lv, Ze-rong Cai, Yi-feng Zou, Ping Lan, Xiao-jian Wu and Feng Gao

ARID1A serves as a receivable biomarker for the resistance to EGFR-TKIs in non-small cell lung cancer

ARID1A is a key component of the SWI/SNF chromatin remodeling complexes which is important for the maintaining of biological processes of cells. Recent studies had uncovered the potential role of ARID1A alteratio...

Authors: Dantong Sun, Fei Teng, Puyuan Xing and Junling Li

IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy

Obesity-related nephropathy (ORN) has become one of the leading causes of end-stage renal disease and has tripled over the past decade. Previous studies have demonstrated that decreased reactive oxygen species...

Authors: Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang and Li-Yu He

Correction to: Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis

Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang

Increased plasma disequilibrium between pro- and anti-oxidants during the early phase resuscitation after cardiac arrest is associated with increased levels of oxidative stress end-products

Cardiac arrest (CA) results in loss of blood circulation to all tissues leading to oxygen and metabolite dysfunction. Return of blood flow and oxygen during resuscitative efforts is the beginning of reperfusio...

Authors: Muhammad Shoaib, Nancy Kim, Rishabh C. Choudhary, Tai Yin, Koichiro Shinozaki, Lance B. Becker and Junhwan Kim

Correction to: MicroRNA‑214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF‑dependent STAT3 pathway

Authors: Zhi‑Qun Zhang, Hui Hong, Jing Li, Xiao‑Xia Li and Xian‑Mei Huang

Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosyntheti...

Authors: Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey and Sangeeta S. Chavan

Deregulation of circ_003912 contributes to pathogenesis of erosive oral lichen planus by via sponging microRNA-123, -647 and -31 and upregulating FOXP3

The FOXP3/miR-146a/NF-κB axis was previously reported to modulate the induction and function of CD4+ Treg cells to alleviate oral lichen planus. Also, other signaling pathways including microRNA-155-IFN-γ loop...

Authors: Zhen Huang, Fen Liu, Wenjuan Wang, Shaobo Ouyang, Ting Sang, Zikun Huang, Lan Liao and Jun Wu

Long noncoding RNA MAPKAPK5-AS1 promoted lipopolysaccharide-induced inflammatory damage in the myocardium by sponging microRNA-124-3p/E2F3

Myocardial dysfunction caused by sepsis (SIMD) leads to high mortality in critically ill patients. We investigated the function and mechanism of long non-coding RNA MAPKAPK5-AS1 (lncRNA MAPKAPK-AS1) on lipopol...

Authors: Weiwei Chen, Guangyuan Gao, Mengjie Yan, Ming Yu, Kaiyao Shi and Ping Yang

Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway

HPV16 is the predominant cancer-causing strain that is responsible for over 50% of all cervical cancers. In this study, we aim to investigate the therapeutic effect of heat shock protein 90 (Hsp90) knockdown o...

Authors: Jie Zeng, Si-Li He, Li-Jie Li and Chen Wang

CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study

Host inflammation contributes to determine whether SARS-CoV-2 infection causes mild or life-threatening disease. Tools are needed for early risk assessment.

Authors: Nicola I. Lorè, Rebecca De Lorenzo, Paola M. V. Rancoita, Federica Cugnata, Alessandra Agresti, Francesco Benedetti, Marco E. Bianchi, Chiara Bonini, Annalisa Capobianco, Caterina Conte, Angelo Corti, Roberto Furlan, Paola Mantegani, Norma Maugeri, Clara Sciorati, Fabio Saliu…

Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway

Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played a tumorigenic role in various types of cancer and miR-23b-5p was down-regulated in human mese...

Authors: Hui Cheng, Jie Ding, Gusheng Tang, Aijie Huang, Lei Gao, Jianmin Yang and Li Chen

d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays...

Authors: Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu, Yuanjian Yang and Wei Wang

The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) have witnessed the achievements of convincing clinical benefits that feature the significantly prolonged overall survival (OS) of patients suffering from advanced non-small ...

Authors: Xilin Hu, Hanlin Xu, Qianwen Xue, Ruran Wen, Wenjie Jiao and Kaihua Tian

The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Disc...

Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son and Jeon-Soo Shin

Depression of lncRNA MINCR antagonizes LPS-evoked acute injury and inflammatory response via miR-146b-5p and the TRAF6-NFkB signaling

Inflammation plays an important role in the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The long non-coding RNA (lncRNA) MINCR is closely related to inflammation inju...

Authors: Wei Gao and Ying Zhang

New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases

Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase...

Authors: Wujun Chen, Yingjie Zhong, Nuan Feng, Zhu Guo, Shuai Wang and Dongming Xing

Role of long non-coding RNA H19 in the development of osteoporosis

Osteoporosis is a widespread and serious metabolic bone disease. At present, revealing the molecular mechanisms of osteoporosis and developing effective prevention and treatment methods are of great significan...

Authors: Senxiang Chen, Da Liu, Zimo Zhou and Sen Qin

Macrophages and cancer stem cells: a malevolent alliance

Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. Th...

Authors: Paola Allavena, Elisabeth Digifico and Cristina Belgiovine

Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues

Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particula...

Authors: Martin Begemann, Oliver Gross, Dominik Wincewicz, Rüdiger Hardeland, Vinicius Daguano Gastaldi, Eduard Vieta, Karin Weissenborn, Kamilla W. Miskowiak, Onnen Moerer and Hannelore Ehrenreich

Intracolic ultrasound molecular imaging: a novel method for assessing colonic tumor necrosis factor-α expression in inflammatory bowel disease

While anti-tumor necrosis factor alpha (TNF-α) therapy has been proven effective in inflammatory bowel disease (IBD), approximately 40% of patients lose the response. Transmembrane TNF-α (mTNF-α) expression in...

Authors: Xiaoyan Miao, Ren Mao, Yujia You, Huichao Zhou, Chen Qiu, Xuehua Li, Zhihui Chen, Jie Ren, Minhu Chen, Ping Wang, Rongqin Zheng and Tinghui Yin

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism

The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the activ...

Authors: Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han and Pei Jiang

Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients

GINS4, an indispensable component of the GINS complex, is vital for a variety of cancer. However, no known empirical research has focused on exploring relationships between GINS4 and glioma. Thus, this study aims...

Authors: Binfeng Liu, Zhendong Liu, Yanbiao Wang, Xiaoyu Lian, Zhibin Han, Xingbo Cheng, Yongjie Zhu, Runze Liu, Yaoye Zhao and Yanzheng Gao

Suppression of CRLF1 promotes the chondrogenic differentiation of bone marrow-derived mesenchymal stem and protects cartilage tissue from damage in osteoarthritis via activation of miR-320

Osteoarthritis (OA) is the most prevalent chronic joint disease, and is hard to be cured at present. Cytokine receptor-like factor 1 (CRLF1) has been identified as an upregulated gene in OA cartilage. However,...

Authors: Hao Xu, Changrong Ding, Cuicui Guo, Shuai Xiang, Yingzhen Wang, Bing Luo and Hongfei Xiang

The mechanism of nicotinamide on reducing acute lung injury by inhibiting MAPK and NF-κB signal pathway

Acute lung injury is an important factor that leads to the death of patients with pneumonia. Previous studies have shown that nicotinamide (NAM) plays a role in reducing cell damage, so this study explored the...

Authors: Qun Zhang, Junyao Li, Haixia Zhong and Yanling Xu

Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer

Changes in DNA methylation of immunosuppressive checkpoints may impact express and consequently affect antigen processing and presentation by tumor cells and facilitates evasion of immunosurveillance and lead ...

Authors: Yuanyuan Zhang, Lei zhang, Hongru Sun, Ying Liu, Jing Xu, Hao Huang, Jinming Fu, Ding Zhang, Tian Tian, Yashuang Zhao and Guiyu Wang

Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling

Increasing evidence has indicated that circular RNAs (circRNAs) play a role in various diseases. However, the influence of circRNAs in nephritis remains unknown.

Authors: Peng-Wei Guo, Hai-Ting Huang, Jing Ma, Yao Zuo, Dan Huang, Lin-Lin He, Zi-Ming Wan, Cheng Chen, Fa-Fen Yang and Yan-Wu You

Extreme immunotherapy: emergency immunology to defeat pandemics

The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology’s ability to investigate and respond to a novel pathogen and modern medicine’s ability to marshal effective fron...

Authors: Douglas F. Nixon, Daniela Marín-Hernández and Nathaniel Hupert

Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease

Parkinson’s disease (PD) commences several years before the onset of motor features. Pathophysiological understanding of the pre-clinical or early prodromal stages of PD are essential for the development of ne...

Authors: Sanne K. Meles, Wolfgang H. Oertel and Klaus L. Leenders

Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90

Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6), a unique histone deacetylase with two functional catalytic d...

Authors: Ping Liu, Ji Xiao, Yiliang Wang, Xiaowei Song, Lianzhou Huang, Zhe Ren, Kaio Kitazato and Yifei Wang

MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway

Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-214 is possibly implicated in bronchopulmonary dysplasia (BPD) have not ...

Authors: Zhi-Qun Zhang, Hui Hong, Jing Li, Xiao-Xia Li and Xian-Mei Huang

A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents

Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism...

Authors: Sofia Moran-Ramos, Luis Macias-Kauffer, Blanca E. López-Contreras, Hugo Villamil-Ramírez, Elvira Ocampo-Medina, Paola León-Mimila, Blanca E. del Rio-Navarro, Omar Granados-Portillo, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Armando R. Tovar, Nimbe Torres, Francisco J. Gomez-Perez, Carlos Aguilar-Salinas and Samuel Canizales-Quinteros

Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis

Studies have widely explored in the filed of ischemic stroke (IS) with their focus on transcription factors. However, few studies have pivoted on sex determining region Y-box 2 (SOX2) in IS. Thus, this study i...

Authors: Zhongjun Chen, Tieping Fan, Xusheng Zhao and Zhichen Zhang

METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho

N6-Methyladenosine (m6A) modification has been implicated in many bioprocesses. However, its functions in diabetic nephropathy (DN) have not been determined. Here, we investigated the role of METTL14, a key co...

Authors: Manna Li, Le Deng and Gaosi Xu

Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry

Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial...

Authors: Rodrigo R. R. Duarte, Dennis C. Copertino Jr., Luis P. Iñiguez, Jez L. Marston, Yaron Bram, Yuling Han, Robert E. Schwartz, Shuibing Chen, Douglas F. Nixon and Timothy R. Powell

An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation

The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be c...

Authors: Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara and Kenneth R. Chien