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  1. Content type: Research article

    Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for ...

    Authors: Huan Yang, Hui Liu, Qiong Zeng, Gavin H. Imperato, Meghan E. Addorisio, Jianhua Li, Mingzhu He, Kai Fan Cheng, Yousef Al-Abed, Helena E. Harris, Sangeeta S. Chavan, Ulf Andersson and Kevin J. Tracey

    Citation: Molecular Medicine 2019 25:13

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  2. Content type: Research article

    The polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we exa...

    Authors: Kim R. Simpfendorfer, Nancy Wang, Dedreia L. Tull, David P. De Souza, Amsha Nahid, Andre Mu, Dianna M. Hocking, John S. Pedersen, Odilia L. C. Wijburg, Malcolm J. McConville and Richard A. Strugnell

    Citation: Molecular Medicine 2019 25:12

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  3. Content type: Research article

    Endometrial carcinoma represents one of the most common cancer types of the female reproductive tract. If diagnosed at an early stage, the 5-year survival rate is promising. However, recurrence and chemoresist...

    Authors: Jing-Wei Zhou, Juan-Juan Tang, Wei Sun and Hui Wang

    Citation: Molecular Medicine 2019 25:11

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  4. Content type: Research article

    The pathological features of aortic dissection (AD) include vascular smooth muscle cell (VSMC) loss, elastic fiber fraction, and inflammatory responses in the aorta. However, little is known about the post-tra...

    Authors: Xian Guo, Ze-Min Fang, Xiang Wei, Bo Huo, Xin Yi, Cai Cheng, Jun Chen, Xue-Hai Zhu, Anas Omar Khalil Abu Bokha and Ding-Sheng Jiang

    Citation: Molecular Medicine 2019 25:10

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  5. Content type: Research article

    Cell therapy is proposed to be a potential treatment for Parkinson’s disease (PD). Although fetal retinal pigment epithelial (RPE) cells have been tested in trials for treating PD patients, controversy has bee...

    Authors: Sha Li, Han Zhang, Aifang Wang, Yan Liu, Houqi Liu, Feng Yue, Xianmixinuer Abulaiti, Caiqiao Zhang and Lingsong Li

    Citation: Molecular Medicine 2019 25:9

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  6. Content type: Research article

    2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure (HF), but its effect on short-term adverse outcomes in patients with acu...

    Authors: Zhengliang Peng, Qiong Zhan, Xiangkun Xie, Hanlin Li, Yan Tu, Yujia Bai, Xingfu Huang, Wenyan Lai, Boxin Zhao, Qingchun Zeng and Dingli Xu

    Citation: Molecular Medicine 2019 25:8

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  7. Content type: Research article

    Long non-coding RNAs (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been shown to be associated with liver fibrosis. Nevertheless, the role of PVT1 in atrial fibrosis remains undefined. This study ai...

    Authors: Feng Cao, Zhe Li, Wen-mao Ding, Ling Yan and Qing-yan Zhao

    Citation: Molecular Medicine 2019 25:7

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  8. Content type: Research article

    Deleterious variants in the voltage-gated sodium channel type 2 (Nav1.2) lead to a broad spectrum of phenotypes ranging from benign familial neonatal-infantile epilepsy (BFNIE), severe developmental and epileptic...

    Authors: Anaïs Begemann, Mario A. Acuña, Markus Zweier, Marie Vincent, Katharina Steindl, Ruxandra Bachmann-Gagescu, Annette Hackenberg, Lucia Abela, Barbara Plecko, Judith Kroell-Seger, Alessandra Baumer, Kazuhiro Yamakawa, Yushi Inoue, Reza Asadollahi, Heinrich Sticht, Hanns Ulrich Zeilhofer…

    Citation: Molecular Medicine 2019 25:6

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  9. Content type: Research article

    Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the...

    Authors: Wen-Chih Chiang, Yu-Chin Huang, Ten-I Fu, Ping-Min Chen, Fan-Chi Chang, Chun-Fu Lai, Vin-Cent Wu, Shuei-Liong Lin and Yung-Ming Chen

    Citation: Molecular Medicine 2019 25:5

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  10. Content type: Research article

    Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible ...

    Authors: Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll and Alex F. de Vos

    Citation: Molecular Medicine 2019 25:3

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  11. Content type: Research article

    Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Here, we sought to investigate the glucose metabolism characteristics of SUR1−/− rats.

    Authors: Xiaojun Zhou, Chunmei Xu, Zhiwei Zou, Xue Shen, Tianyue Xie, Rui Zhang, Lin Liao and Jianjun Dong

    Citation: Molecular Medicine 2019 25:2

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  12. Content type: Research article

    Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to invest...

    Authors: Rose A. Willemze, Olaf Welting, Patricia van Hamersveld, Caroline Verseijden, Laurens E. Nijhuis, Francisca W. Hilbers, Sybren L. Meijer, Balthasar A. Heesters, Joost H. A. Folgering, Harold Darwinkel, Philippe Blancou, Margriet J. Vervoordeldonk, Jurgen Seppen, Sigrid E. M. Heinsbroek and Wouter J. de Jonge

    Citation: Molecular Medicine 2019 25:1

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  13. Content type: Research

    Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate c...

    Authors: Yiting Tang, Rui Zhang, Qianqian Xue, Ran Meng, Xiangyu Wang, Yanliang Yang, Lingli Xie, Xianzhong Xiao, Timothy R. Billiar and Ben Lu

    Citation: Molecular Medicine 2018 24:66

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  14. Content type: Research article

    Numerous host cellular factors are exploited by viruses to facilitate infection. Our previous studies and those of others have shown heat-shock protein 90 (Hsp90), a cellular molecular chaperone, is involved i...

    Authors: Yiliang Wang, Rongze Wang, Feng Li, Yun Wang, Zhen Zhang, Qiaoli Wang, Zhe Ren, Fujun Jin, Kaio Kitazato and Yifei Wang

    Citation: Molecular Medicine 2018 24:65

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  15. Content type: Research article

    The multiple biological effects of vitamin D and its novel activities on inflammation and redox homeostasis have raised high expectations on its use as a therapeutic agent for multiple fibrogenic conditions. W...

    Authors: Trinidad Guijarro, Esmeralda Magro-Lopez, Joana Manso, Ricardo Garcia-Martinez, Maria Jesus Fernandez-Aceñero, Isabel Liste and Alberto Zambrano

    Citation: Molecular Medicine 2018 24:64

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  16. Content type: Research article

    Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought t...

    Authors: Rafael Y. Brzezinski, Eyal Fisher, Noa Cohen, Etti Zwang, Gabi Shefer, Naftali Stern, David Zeltser, Itzhak Shapira, Shlomo Berliner, Ori Rogowski and Shani Shenhar-Tsarfaty

    Citation: Molecular Medicine 2018 24:63

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  17. Content type: Research article

    Gold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown. The aim of this study is to explore the effect of AuN...

    Authors: Hui Yang, Libo Du, Guangjun Wu, Zhenyu Wu and Jeffrey A. Keelan

    Citation: Molecular Medicine 2018 24:62

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  18. Content type: Research article

    There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD)...

    Authors: Yue Dong, Li-Li Han and Zhong-Xin Xu

    Citation: Molecular Medicine 2018 24:61

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  19. Content type: Research article

    We tested the hypothesis that extracorporeal shockwave treatment (ESWT) can abolish inflammation and restore urothelial barrier integrity in acute interstitial cystitis by upregulating the fatty acid receptor ...

    Authors: Yi-Ling Chen, Yuan-Ping Lin, Cheuk-Kwan Sun, Tien-Hung Huang, Hon-Kan Yip and Yen-Ta Chen

    Citation: Molecular Medicine 2018 24:60

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  20. Content type: Review

    Traditional risk factors are insufficient to explain all cases of coronary artery disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products (AGEs) and their receptors may play impo...

    Authors: Sarah Louise Fishman, Halis Sonmez, Craig Basman, Varinder Singh and Leonid Poretsky

    Citation: Molecular Medicine 2018 24:59

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  21. Content type: Research article

    The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion (I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective mechanisms of PPF were linked to its reg...

    Authors: Bei Sun, Hao Ou, Fei Ren, Ye Huan, Tao Zhong, Min Gao and Hongwei Cai

    Citation: Molecular Medicine 2018 24:58

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  22. Content type: Research article

    Gene expression profiles of normal and tumor tissue reflect both differences in biological processes taking place in vivo and differences in response to stress during surgery and sample handling. The effect of...

    Authors: Inge Søkilde Pedersen, Mads Thomassen, Qihua Tan, Torben Kruse, Ole Thorlacius-Ussing, Jens Peter Garne and Henrik Bygum Krarup

    Citation: Molecular Medicine 2018 24:57

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  23. Content type: Research article

    Exposure of rodents to chronic high-fat diet (HFD) results in upregulation of inflammatory markers and proliferation of microglia within the mediobasal hypothalamus. Such hypothalamic inflammation is associate...

    Authors: Mary K. Herrick, Kristin M. Favela, Richard B. Simerly, Naji N. Abumrad and Nathan C. Bingham

    Citation: Molecular Medicine 2018 24:56

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  24. Content type: Research article

    Intestinal barrier dysfunction is a significant clinical problem, commonly developing in a variety of acute or chronic pathological conditions. Herein, we evaluate the effect of microRNA-31 (miR-31) on intesti...

    Authors: Cheng-Ye Zhan, Di Chen, Jin-Long Luo, Ying-Hua Shi and You-Ping Zhang

    Citation: Molecular Medicine 2018 24:55

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  25. Content type: Research article

    Currently, no suitable clinical marker for detection of septic immunosuppression is available. We aimed at identifying microRNAs that could serve as biomarkers of T-cell mediated immunoparalysis in sepsis.

    Authors: P Möhnle, S Hirschberger, L C Hinske, J Briegel, M Hübner, S Weis, G Dimopoulos, M Bauer, E J Giamarellos-Bourboulis and S Kreth

    Citation: Molecular Medicine 2018 24:54

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  26. Content type: Research article

    Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum level...

    Authors: Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran and Ziv Ben-Ari

    Citation: Molecular Medicine 2018 24:53

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  27. Content type: Research article

    For the study, we determine the potential biomarkers and uncover the regulatory mechanisms of lncRNA MALAT1 / miR-145 / SOX9 axis on the abilities of cell growth and cell metastasis of colorectal cancer.

    Authors: Yuanlin Xu, Xihong Zhang, Xiufeng Hu, Wenping Zhou, Peipei Zhang, Jiuyang Zhang, Shujun Yang and Yanyan Liu

    Citation: Molecular Medicine 2018 24:52

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  28. Content type: Research article

    The pro-myelinating effects of leukemia inhibitory factor (LIF) and other cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), have long been known, but controver...

    Authors: Georgina Gyetvai, Cieron Roe, Lamia Heikal, Pietro Ghezzi and Manuela Mengozzi

    Citation: Molecular Medicine 2018 24:51

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  29. Content type: Research article

    MicroRNAs (miRNAs) contribute to the progression of chronic kidney disease (CKD) by regulating renal homeostasis. This study explored the effects of miR-181a on CKD through the Toll-like receptor (TLR)/nuclear...

    Authors: Lei Liu, Xin-Lu Pang, Wen-Jun Shang, Hong-Chang Xie, Jun-Xiang Wang and Gui-Wen Feng

    Citation: Molecular Medicine 2018 24:49

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  30. Content type: Research article

    Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal deformity. The etiology and pathology of AIS remain unexplained, and have been reported to involve a combination of genetic and epigen...

    Authors: Heng Jiang, Fu Yang, Tao Lin, Wei Shao, Yichen Meng, Jun Ma, Ce Wang, Rui Gao and Xuhui Zhou

    Citation: Molecular Medicine 2018 24:48

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  31. Content type: Research article

    Sulfonylureas (SUs) are widely prescribed for the treatment of type 2 diabetes (T2DM). Sulfonylurea receptors (SURs) are their main functional receptors. These receptors are also found in kidney, especially th...

    Authors: Rui Zhang, Xiaojun Zhou, Xue Shen, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong and Lin Liao

    Citation: Molecular Medicine 2018 24:47

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  32. Content type: Review

    Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are small (104 amino acids) and have a striking relationship to the acute phase response with serum levels rising as much as 1000-...

    Authors: George H. Sack Jr

    Citation: Molecular Medicine 2018 24:46

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  33. Content type: Short report

    Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of c...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Molecular Medicine 2018 24:45

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  34. Content type: Research article

    Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune...

    Authors: Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Molecular Medicine 2018 24:44

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  35. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is characterized by pancreatic β-cell failure, which arises from metabolic stress and results in β cell dedifferentiation, leading to β-cell death. Pathological activation of th...

    Authors: Hong Chen, Wenjun Zhou, Yuting Ruan, Lei Yang, Ningning Xu, Rongping Chen, Rui Yang, Jia Sun and Zhen Zhang

    Citation: Molecular Medicine 2018 24:43

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  36. Content type: Research article

    Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disorder of the central nervous system (CNS). Several observations support interactions between vascular and neurodegenerative mechani...

    Authors: Giovanna Marchetti, Nicole Ziliotto, Silvia Meneghetti, Marcello Baroni, Barbara Lunghi, Erica Menegatti, Massimo Pedriali, Fabrizio Salvi, Ilaria Bartolomei, Sofia Straudi, Fabio Manfredini, Rebecca Voltan, Nino Basaglia, Francesco Mascoli, Paolo Zamboni and Francesco Bernardi

    Citation: Molecular Medicine 2018 24:42

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  37. Content type: Research Article

    Retinopathy of prematurity (ROP) remains a major cause of childhood blindness and current laser photocoagulation and anti-VEGF antibody treatments are associated with reduced peripheral vision and possible del...

    Authors: Rong Zhou, Shuya Zhang, Xuejiao Gu, Yuanyuan Ge, Dingjuan Zhong, Yuling Zhou, Lingyun Tang, Xiao-Ling Liu and Jiang-Fan Chen

    Citation: Molecular Medicine 2018 24:41

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  38. Content type: Research article

    This study aimed to investigate the effect of over-expressing circular RNA CEP128 (circCEP128) on cell functions and explore the molecular mechanism of which in bladder carcinoma.

    Authors: Zhun Wu, Wei Huang, Xuegang Wang, Tao Wang, Yuedong Chen, Bin Chen, Rongfu Liu, Peide Bai and Jinchun Xing

    Citation: Molecular Medicine 2018 24:40

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  39. Content type: Research article

    The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the heart by mimicking the cardioprotective effects of ischaemic postc...

    Authors: Fuhua Wang, Huan Wang, Xuejing Liu, Haiyi Yu, Bo Zuo, Zhu Song, Ning Wang, Wei Huang and Guisong Wang

    Citation: Molecular Medicine 2018 24:39

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  40. Content type: Research article

    Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic sec...

    Authors: Valentina Maria Sofia, Cecilia Surace, Vito Terlizzi, Letizia Da Sacco, Federico Alghisi, Antonella Angiolillo, Cesare Braggion, Natalia Cirilli, Carla Colombo, Antonella Di Lullo, Rita Padoan, Serena Quattrucci, Valeria Raia, Giuseppe Tuccio, Federica Zarrilli, Anna Cristina Tomaiuolo…

    Citation: Molecular Medicine 2018 24:38

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  41. Content type: Research article

    Histone deacetylases (HDACs) play a critical role in modulating myocardial protection and cardiomyocyte survivals. However, Specific HDAC isoforms in mediating myocardial ischemia/reperfusion injury remain cur...

    Authors: Ling Zhang, Hao Wang, Yu Zhao, Jianguo Wang, Patrycja M. Dubielecka, Shougang Zhuang, Gangjian Qin, Y Eugene Chin, Race L. Kao and Ting C. Zhao

    Citation: Molecular Medicine 2018 24:37

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  42. Content type: Research article

    This study was to examine the link between astrocyte elevated gene-1 (AEG-1) and hypoxia induced-chemoresistance in T-cell non-Hodgkin’s lymphoma (T-NHL), as well as the underlying molecular mechanisms.

    Authors: Jiaqin Yan, Junhui Zhang, Xudong Zhang, Xin Li, Ling Li, Zhaoming Li, Renyin Chen, Lei Zhang, Jingjing Wu, Xinhua Wang, Zhenchang Sun, Xiaorui Fu, Yu Chang, Feifei Nan, Hui Yu, Xiaolong Wu…

    Citation: Molecular Medicine 2018 24:35

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  43. Content type: Research article

    Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGF) receptor is a receptor tyrosine kinase, which may mediate signalling to promote progression an...

    Authors: Anna Mandel, Per Larsson, Martuza Sarwar, Julius Semenas, Azharuddin Sajid Syed Khaja and Jenny L. Persson

    Citation: Molecular Medicine 2018 24:34

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  44. Content type: Review

    Histone deacetylase 6 (HDAC6), a cytoplasmic enzyme that plays important roles in many biological processes, is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups fro...

    Authors: Ben Ke, Yanxia Chen, Wei Tu, Ting Ye, Xiangdong Fang and Liping Yang

    Citation: Molecular Medicine 2018 24:33

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  45. Content type: Research article

    Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiolog...

    Authors: Sean F. Monaghan, Debasree Banerjee, Chun-Shiang Chung, Joanne Lomas-Neira, Kamil J. Cygan, Christy L. Rhine, William G. Fairbrother, Daithi S. Heffernan, Mitchell M. Levy, William G. Cioffi and Alfred Ayala

    Citation: Molecular Medicine 2018 24:32

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  46. Content type: Correction

    After publication of this article (He et al., 2018), the corresponding authors recognised an error in Scheme 1, in particular to section “A. HMGB1/TLR4/MD-2 complex formation”. Above “Step 2: B box binding to ...

    Authors: Mingzhu He, Marco E. Bianchi, Tom R. Coleman, Kevin J. Tracey and Yousef Al-Abed

    Citation: Molecular Medicine 2018 24:31

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    The original article was published in Molecular Medicine 2018 24:21

  47. Content type: Research article

    Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined significance (MGUS) explicates genetic dependency of this asymptomatic precursor condition with multiple myel...

    Authors: Subhayan Chattopadhyay, Hauke Thomsen, Miguel Inacio da Silva Filho, Niels Weinhold, Per Hoffmann, Markus M. Nöthen, Arendt Marina, Karl-Heinz Jöckel, Börge Schmidt, Sonali Pechlivanis, Christian Langer, Hartmut Goldschmidt, Kari Hemminki and Asta Försti

    Citation: Molecular Medicine 2018 24:30

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