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Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

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  1. asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious pulmonary diseases that contain common and unique characteristics. Therefore, the identification ...

    Authors: Mazaher Maghsoudloo, Sadegh Azimzadeh Jamalkandi, Ali Najafi and Ali Masoudi-Nejad

    Citation: Molecular Medicine 2020 26:9

    Content type: Research article

    Published on:

  2. Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of biochemis...

    Authors: Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Dimitrios P. Bogdanos, Piotr Milkiewicz and Malgorzata Milkiewicz

    Citation: Molecular Medicine 2020 26:8

    Content type: Research article

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  3. Previous studies have found ischemic stroke is associated with atrial fibrillation. However, the causal association between ischemic stroke and atrial fibrillation is not clear. Furthermore, the network relati...

    Authors: Lei Hou, Mingqing Xu, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Lu Liu, Yunxia Li, Tonghui Yuan, Wenchao Li, Hongkai Li and Fuzhong Xue

    Citation: Molecular Medicine 2020 26:7

    Content type: Research article

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  4. The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patt...

    Authors: Zachary Mostel, Abraham Perl, Matthew Marck, Syed F. Mehdi, Barbara Lowell, Sagar Bathija, Ramchandani Santosh, Valentin A. Pavlov, Sangeeta S. Chavan and Jesse Roth

    Citation: Molecular Medicine 2019 26:6

    Content type: Review

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  5. HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, d...

    Authors: William Ottestad, Ingrid N. Rognes, Erlend Skaga, Cassandra Frisvoll, Guttorm Haraldsen, Torsten Eken and Peter Lundbäck

    Citation: Molecular Medicine 2019 26:5

    Content type: Research article

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  6. The main features of bronchopulmonary dysplasia (BPD) are alveolar simplification, pulmonary growth arrest, and abnormal lung function. Multiple studies have highlighted microRNA-29 (miR-29) as a potential bio...

    Authors: Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou and Hanmin Liu

    Citation: Molecular Medicine 2019 26:3

    Content type: Research article

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  7. In mammalians, serotonin (5-HT) has critical roles in the central nervous system (CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority of serotonin is produced by intes...

    Authors: Alejandro Quintero-Villegas and Sergio Iván Valdés-Ferrer

    Citation: Molecular Medicine 2019 26:2

    Content type: Mini-review

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  8. Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...

    Authors: Lourdes Valdés-Sánchez, Sofia M. Calado, Berta de la Cerda, Ana Aramburu, Ana Belén García-Delgado, Simone Massalini, Adoración Montero-Sánchez, Vaibhav Bhatia, Eduardo Rodríguez-Bocanegra, Andrea Diez-Lloret, Daniel Rodríguez-Martínez, Christina Chakarova, Shom S. Bhattacharya and Francisco J. Díaz-Corrales

    Citation: Molecular Medicine 2019 26:1

    Content type: Research article

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  9. The incidence and mortality of strokes have increased over the past three decades in China. Ischemic strokes can cause a sequence of detrimental events in patients, including increased permeability and dysfunc...

    Authors: Zili Feng, Qian Sun, Wang Chen, Yu Bai, Daihua Hu and Xin Xie

    Citation: Molecular Medicine 2019 25:57

    Content type: Review

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  10. There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act s...

    Authors: Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi and Toshiro Okazaki

    Citation: Molecular Medicine 2019 25:56

    Content type: Research article

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  11. Pancreatic cancer (PC) is a type of malignant gastrointestinal tumor. Long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to stimulate proliferation, migration and invasion in several typ...

    Authors: Ming Yang, Shijuan Sun, Yao Guo, Junjie Qin and Guangming Liu

    Citation: Molecular Medicine 2019 25:55

    Content type: Research article

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  12. Intestinal mucosa barrier dysfunction after burn injury is an important factor for causing mortality of burn patients. The current study established a burn model in rats and used a free radical scavenger edara...

    Authors: Jiaxiang Ke, Xi Bian, Hu Liu, Bei Li and Ran Huo

    Citation: Molecular Medicine 2019 25:54

    Content type: Research article

    Published on:

  13. Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adv...

    Authors: Shimin An, Nimra Gilani, Yuan Huang, Adam Muncan, Youhua Zhang, Yi-Da Tang, A. Martin Gerdes and Kaie Ojamaa

    Citation: Molecular Medicine 2019 25:53

    Content type: Research article

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  14. Alcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth factor-factor VIII (MFG-E8), a glycoprotein essential for optimal efferocytos...

    Authors: Wayne W. Chaung, Max Brenner, Hao-Ting Yen, Mahendar L. Ochani, Asha Jacob and Ping Wang

    Citation: Molecular Medicine 2019 25:52

    Content type: Research article

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  15. This study aimed to investigate the differences in the serum levels of glucose, lipid, and thyroid function markers between unipolar and bipolar depressed patients, as well as the effect of anhedonia and suici...

    Authors: Meilei Su, Enze Li, Chong Tang, Yongzhi Zhao, Ruqing Liu and Keming Gao

    Citation: Molecular Medicine 2019 25:51

    Content type: Research article

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  16. Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulat...

    Authors: Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria and Nhan L. Tran

    Citation: Molecular Medicine 2019 25:49

    Content type: Research article

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  17. To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.

    Authors: Meruyert Massabayeva, Nailya Chaizhunusova, Nurlan Aukenov, Tolkyn Bulegenov, Bakytbek Apsalikov, Aigerim Shapihanova and Yersin Zhunussov

    Citation: Molecular Medicine 2019 25:48

    Content type: Research article

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  18. The hunt for the molecular markers with specificity and sensitivity has been a hot area for the tumor treatment. Due to the poor diagnosis and prognosis of pancreatic cancer (PC), the excision rate is often lo...

    Authors: Yang-Yang Zhou, Li-Ping Chen, Yi Zhang, Sun-Kuan Hu, Zhao-Jun Dong, Ming Wu, Qiu-Xiang Chen, Zhi-Zhi Zhuang and Xiao-Jing Du

    Citation: Molecular Medicine 2019 25:47

    Content type: Research article

    Published on:

  19. Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes rel...

    Authors: Wai Hoong Chang and Alvina G. Lai

    Citation: Molecular Medicine 2019 25:46

    Content type: Research article

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  20. Club Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-in...

    Authors: Baolin Xu, Andrea Janicova, Jan Tilmann Vollrath, Philipp Störmann, Lukas Martin, Ingo Marzi, Sebastian Wutzler, Frank Hildebrand, Sabrina Ehnert and Borna Relja

    Citation: Molecular Medicine 2019 25:45

    Content type: Research article

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  21. Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/...

    Authors: Qicai Liu, Ling Guo, Sheng Zhang, Jingwen Wang, Xinhua Lin and Feng Gao

    Citation: Molecular Medicine 2019 25:44

    Content type: Research article

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  22. The protective effect of melatonin against bone metabolism imbalance in osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this study was to explore the role of melatonin in b...

    Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang

    Citation: Molecular Medicine 2019 25:43

    Content type: Research article

    Published on:

  23. HER2 is considered as one of the most important, predictive biomarkers in oncology. The diagnosis of HER2 positive cancer types such as breast- and gastric cancer is usually based on immunohistochemical HER2 s...

    Authors: Diana B. Peckys, Daniela Hirsch, Timo Gaiser and Niels de Jonge

    Citation: Molecular Medicine 2019 25:42

    Content type: Research article

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  24. Peritoneal fibrosis (PF) represents a long-term complication of peritoneal dialysis (PD), affecting peritoneal membrane (PM) integrity and function. Understanding the mechanisms underlying PF development in an...

    Authors: Filipe M. O. Silva, Elerson C. Costalonga, Cleonice Silva, Ana C. O. Carreira, Samirah A. Gomes, Mari C. Sogayar, Camilla Fanelli and Irene L. Noronha

    Citation: Molecular Medicine 2019 25:41

    Content type: Research article

    Published on:

  25. Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. ...

    Authors: Takashi Tani, Ken Okamoto, Megumi Fujiwara, Akira Katayama and Shuichi Tsuruoka

    Citation: Molecular Medicine 2019 25:40

    Content type: Research article

    Published on:

  26. Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammato...

    Authors: Marie Hilderman, Abdul Rashid Qureshi, Farhad Abtahi, Nils Witt, Christina Jägren, Joakim Olbers, Martin Delle, Kaj Lindecrantz and Annette Bruchfeld

    Citation: Molecular Medicine 2019 25:39

    Content type: Research article

    Published on:

  27. Early distinction between refractory M. pneumoniae pneumonia (RMPP) and non-RMPP (NRMPP) is still difficult. The community-acquired respiratory distress syndrome (CARDS) toxin can induce inflammatory and histopat...

    Authors: Gang Li, Liping Fan, Yuqing Wang, Li Huang, Meijuan Wang, Canhong Zhu, Chuangli Hao, Wei Ji, Hansi Liang, Yongdong Yan and Zhengrong Chen

    Citation: Molecular Medicine 2019 25:38

    Content type: Research article

    Published on:

  28. Human reproductive disorders consist of frequently occurring dysfunctions including a broad range of phenotypes affecting fertility and women’s health during pregnancy. Several female-related diseases have bee...

    Authors: Paula Quintero-Ronderos, Karen Marcela Jiménez, Clara Esteban-Pérez, Diego A. Ojeda, Sandra Bello, Dora Janeth Fonseca, María Alejandra Coronel, Harold Moreno-Ortiz, Diana Carolina Sierra-Díaz, Elkin Lucena, Sandrine Barbaux, Daniel Vaiman and Paul Laissue

    Citation: Molecular Medicine 2019 25:37

    Content type: Short report

    Published on:

  29. Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children and Glucocorticoids (GCs) form an essential component of the standard chemotherapy in most treatment regimens. The cat...

    Authors: Zaynab Mousavian, Abbas Nowzari-Dalini, Yasir Rahmatallah and Ali Masoudi-Nejad

    Citation: Molecular Medicine 2019 25:36

    Content type: Research article

    Published on:

  30. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose onset and progression are affected by genetic and environmental factors. The purpose of this study is to identify the influence of gut m...

    Authors: Yiyangzi Ma, Xiaoxue Xu, Mengtao Li, Jun Cai, Qiang Wei and Haitao Niu

    Citation: Molecular Medicine 2019 25:35

    Content type: Research article

    Published on:

  31. Following publication of the original article [1], the author reported an error in Figure 1. The correct version of Figure 1 is as follows:

    Authors: Vijay K. Sonkar, Paresh P. Kulkarni, Susheel N. Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata Dash

    Citation: Molecular Medicine 2019 25:34

    Content type: Correction

    Published on:

    The original article was published in Molecular Medicine 2016 22:2201224

  32. The beneficial effects of angiotensin II type 1 receptor blockers (ARBs) on atherosclerosis have been demonstrated in numerous studies. We investigated the effects of fimasartan on reducing neointimal formatio...

    Authors: Jong-Ho Kim, I-Rang Lim, Hyung Joon Joo, Chi-Yeon Park, Seung-Cheol Choi, Han Saem Jeong and Soon Jun Hong

    Citation: Molecular Medicine 2019 25:33

    Content type: Research article

    Published on:

  33. Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the...

    Authors: Junling Zhao, Hsiao Tung Yang, Lakmini Wasala, Keqing Zhang, Yongping Yue, Dongsheng Duan and Yi Lai

    Citation: Molecular Medicine 2019 25:31

    Content type: Research article

    Published on:

  34. Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume ...

    Authors: Ali Khosravi, B. Jayaram, Bahram Goliaei and Ali Masoudi-Nejad

    Citation: Molecular Medicine 2019 25:30

    Content type: Research article

    Published on:

  35. Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of L...

    Authors: Yuya Asanomi, Daichi Shigemizu, Akinori Miyashita, Risa Mitsumori, Taiki Mori, Norikazu Hara, Kaoru Ito, Shumpei Niida, Takeshi Ikeuchi and Kouichi Ozaki

    Citation: Molecular Medicine 2019 25:20

    Content type: Research article

    Published on:

  36. Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immu...

    Authors: Cheng Zhang, Feng Chen, Li Feng, Qun Shan, Gui-Hong Zheng, Yong-Jian Wang, Jun Lu, Shao-Hua Fan, Chun-Hui Sun, Dong-Mei Wu, Meng-Qiu Li, Bin Hu, Qing-Qing Wang, Zi-Feng Zhang and Yuan-Lin Zheng

    Citation: Molecular Medicine 2019 25:29

    Content type: Research article

    Published on:

  37. Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology with only two federally approved drug options. Given the complex molecular pathogenesis of IPF involving multiple cell types and ...

    Authors: L. R. Rodriguez, S. N. Bui, R. T. Beuschel, E. Ellis, E. M. Liberti, M. K. Chhina, B. Cannon, M. Lemma, S. D. Nathan and G. M. Grant

    Citation: Molecular Medicine 2019 25:27

    Content type: Research article

    Published on:

  38. Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-12...

    Authors: Jun-Ke Long, Wen Dai, Ya-Wen Zheng and Shui-Ping Zhao

    Citation: Molecular Medicine 2019 25:26

    Content type: Research article

    Published on:

  39. Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build a...

    Authors: Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Li Jin, Hejian Zou, Shifang Ren and Jiucun Wang

    Citation: Molecular Medicine 2019 25:25

    Content type: Short report

    Published on:

  40. Alcohol abuse affects the brain regions responsible for memory, coordination and emotional processing. Binge alcohol drinking has shown reductions in brain activity, but the molecular targets have not been com...

    Authors: Asha Jacob, Yilong Ma, Elham Nasiri, Mahendar Ochani, Joseph Carrion, Shichun Peng, Max Brenner, Patricio T. Huerta and Ping Wang

    Citation: Molecular Medicine 2019 25:24

    Content type: Research article

    Published on:

  41. Cervical cancer is the third most common gynecological malignancy. Conventional treatment options are known to be ineffective for the majority of patients with advanced or recurrent cervical cancer. Therefore,...

    Authors: Sungha Lee, Jung Yoon Ho, Jing Jing Liu, Hyewon Lee, Jae Young Park, Minwha Baik, Minji Ko, Seon Ui Lee, Youn Jin Choi and Soo Young Hur

    Citation: Molecular Medicine 2019 25:23

    Content type: Research article

    Published on:

  42. Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition ...

    Authors: Tao Jiang, Meiyan Wu, Zhanqin Zhang, Chaoying Yan, Zhi Ma, Shan He, Wei Yuan, Kairui Pu and Qiang Wang

    Citation: Molecular Medicine 2019 25:22

    Content type: Research article

    Published on:

  43. Metabolic memory contributes to the development of diabetic retinopathy (DR), which is the complication of diabetes. But it’s still unknown how to prevent the metabolic memory to treat the DR. In our study, we...

    Authors: Ping Liu, Qing-Hua Peng, Ping Tong and Wen-Jie Li

    Citation: Molecular Medicine 2019 25:21

    Content type: Research article

    Published on:

  44. The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their per...

    Authors: Amol Kolte and Rainer König

    Citation: Molecular Medicine 2019 25:19

    Content type: Research article

    Published on:

  45. Acute myocardial infarction (AMI) was considered to be one of the major causes of morbidity and mortality worldwide. In order to manage the acute myocardial infarction outbreaks, accurate biomarkers for risk p...

    Authors: Sheng Xue, Wenjie Zhu, Dacheng Liu, Zhe Su, Liwei Zhang, Qing Chang and Peifeng Li

    Citation: Molecular Medicine 2019 25:18

    Content type: Research article

    Published on:

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