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  1. Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histam...

    Authors: Huan Yang, Sam J. George, Dane A. Thompson, Harold A. Silverman, Téa Tsaava, Aisling Tynan, Valentin A. Pavlov, Eric H. Chang, Ulf Andersson, Michael Brines, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Molecular Medicine 2022 28:57
    Content type: Research article Published on:

  2. The dynamic balance of osteoblast and osteoclast is critical for bone homeostasis and overactive osteoclastic function may lead to osteoporosis. Activating transcription factor 1 (ATF1) is involved in osteocla...

    Authors: Lu-Lin Liu, Yao-Sheng Xiao, Wei-Min Huang, Sheng Liu, Li-Xing Huang, Jing-Hua Zhong, Peng Jia and Wu-Yang Liu
    Citation: Molecular Medicine 2022 28:56
    Content type: Research article Published on:

  3. The aim of this study was to draw a comprehensive mutational landscape of nasopharyngeal carcinoma (NPC) tumors and identify the prognostic factors for distant metastasis-free survival (DMFS).

    Authors: Zihan Zhou, Peifeng Li, Xianbin Zhang, Juan Xu, Jin Xu, Shui Yu, Dongqing Wang, Wei Dong, Xiujuan Cao, Hongjiang Yan, Mingping Sun, Xiuping Ding, Jun Xing, Peng Zhang, Limin Zhai, Tingyong Fan…
    Citation: Molecular Medicine 2022 28:55
    Content type: Research article Published on:

  4. Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition. Emerging evidence indicate that...

    Authors: Caroline Boulouis, Tobias Kammann, Angelica Cuapio, Tiphaine Parrot, Yu Gao, Elli Mouchtaridi, David Wullimann, Joshua Lange, Puran Chen, Mira Akber, Olga Rivera Ballesteros, Jagadeeswara Rao Muvva, C. I. Edvard Smith, Jan Vesterbacka, Oscar Kieri, Piotr Nowak…
    Citation: Molecular Medicine 2022 28:54
    Content type: Research article Published on:

  5. Authors: Chun Xi Liu, Qin Hu, Yan Wang, Wei Zhang, Zhi Yong Ma, Jin Bo Feng, Rong Wang, Xu Ping Wang, Bo Dong, Fei Gao, Ming Xiang Zhang and Yun Zhang
    Citation: Molecular Medicine 2022 28:53
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2010 17:Art10

  6. The altered gut microbiota is implicated in the pathogenesis of liver fibrosis. Resveratrol is a candidate for the treatment of liver fibrosis, which could ameliorate the dysregulation of gut microbiota in mic...

    Authors: Zhiqin Li, Jianxia Dong, Meng Wang, Jingya Yan, Yushu Hu, Yang Liu, Yajie Pan and Hua Li
    Citation: Molecular Medicine 2022 28:52
    Content type: Research article Published on:

  7. Thrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly...

    Authors: Bjoern F. Kraemer, Irina Hennis, Anne Karge, Anne Katrin Kraemer, Tobias F. Dreyer, Marion Kiechle, Bettina Kuschel and Holger Bronger
    Citation: Molecular Medicine 2022 28:51
    Content type: Research article Published on:

  8. The conversion of astrocytes activated by nerve injuries to oligodendrocytes is not only beneficial to axonal remyelination, but also helpful for reversal of glial scar. Recent studies have shown that patholog...

    Authors: Xinyu Liu, Conghui Li, Jiao Li, Lesi Xie, Zeng Hong, Kang Zheng, Xiaofeng Zhao, Aifen Yang, Xiaofeng Xu, Huaping Tao, Mengsheng Qiu and Junlin Yang
    Citation: Molecular Medicine 2022 28:50
    Content type: Research article Published on:

  9. The existence of breast cancer stem cells (BCSCs) causes tumor relapses, metastasis and resistance to conventional therapy in breast cancer. NDR1 kinase, a component of the Hippo pathway, plays important roles...

    Authors: Ling-Ling Wang, Xiao-Yun Wan, Chun-Qi Liu and Fei-Meng Zheng
    Citation: Molecular Medicine 2022 28:49
    Content type: Research article Published on:

  10. The appearance of alterations in normal metabolic activity has been increasingly considered a risk factor for the development of sporadic and late-onset neurodegenerative diseases. In this report, we induced c...

    Authors: Oriol Busquets, Triana Espinosa-Jiménez, Miren Ettcheto, Jordi Olloquequi, Mònica Bulló, Eva Carro, José Luis Cantero, Gemma Casadesús, Jaume Folch, Ester Verdaguer, Carme Auladell and Antoni Camins
    Citation: Molecular Medicine 2022 28:48
    Content type: Research article Published on:

  11. Receptor-interacting protein kinase 2 (RIPK2, also known as RIP2) was reported to be associated with bacterial infections as well as inflammatory responses. However, the role of RIPK2 in prognosis and immunoth...

    Authors: Junquan Song, Runyu Yang, Rongyuan Wei, Yue Du, Pengcheng He and Xiaowen Liu
    Citation: Molecular Medicine 2022 28:47
    Content type: Research article Published on:

  12. Risperidone, an atypical antipsychotic, impedes serotonin and dopamine receptor systems. Meanwhile, tumor necrosis factor-α (TNF-α) is known to participate in regulating osteoblast functions. Consequently, the...

    Authors: Shuyao Zhang, Wei He, Aiguo Li, Chengkuan Zhao, Yun Chen, Chengcheng Xu, Qiuzhen Zhang, Danling Zheng, Meini Chen, Haixiong Miao and Yihui Huang
    Citation: Molecular Medicine 2022 28:46
    Content type: Research article Published on:

  13. Clinical data suggest that male reproductive dysfunction especially infertility is a critical issue for type 1 diabetic patient (T1D) because most of them are at the reproductive age. Gut dysbiosis is involved...

    Authors: Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Ruqing Zhong, Xiangfang Tang, Wei Shen, Qingyuan Sun, Zhongyi Sun, Yonglin Ren, Hongfu Zhang and Yong Zhao
    Citation: Molecular Medicine 2022 28:45
    Content type: Research article Published on:

  14. Menopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety concerns with long-term treatment. We investigated the ability of 2′,3...

    Authors: Candice B. Herber, Chaoshen Yuan, Anthony Chang, Jen-Chywan Wang, Isaac Cohen and Dale C. Leitman
    Citation: Molecular Medicine 2022 28:44
    Content type: Research article Published on:

  15. Pancreatic cancer (PC) is a malignancy with a poor prognosis and high mortality. Surgical resection is the only “curative” treatment. However, only a minority of patients with PC can obtain surgery. Improving ...

    Authors: Wei Li, Tiandong Li, Chenguang Sun, Yimeng Du, Linna Chen, Chunyan Du, Jianxiang Shi and Weijie Wang
    Citation: Molecular Medicine 2022 28:43
    Content type: Research article Published on:

  16. Colorectal cancer (CRC), a common malignancy, is one of the leading cause of cancer death in adults. AT-rich interaction domain 1A (ARID1A), a critical portion of the SWItch/sucrose non-fermentation (SWI/SNF) chr...

    Authors: Shankun Zhao, Weizhou Wu, Zufu Jiang, Fuqin Tang, Lingzhi Ding, Weifang Xu and Libin Ruan
    Citation: Molecular Medicine 2022 28:42
    Content type: Review Published on:

  17. The mechanisms of Gastric cancer (GC) initiation and progression are complicated, at least partly owing to the dynamic changes of gene regulation during carcinogenesis. Thus, investigations on the changes in r...

    Authors: Beiqin Yu, Wentao Dai, Li Pang, Qingqing Sang, Fangyuan Li, Junxian Yu, Haoran Feng, Jianfang Li, Junyi Hou, Chao Yan, Liping Su, Zhenggang Zhu, Yuan-Yuan Li and Bingya Liu
    Citation: Molecular Medicine 2022 28:41
    Content type: Research article Published on:

  18. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already caused 6 million deaths worldwide. While asymptomatic individuals are responsible of many potential transmissions, the difficulty to ide...

    Authors: Lucía Beltrán-Camacho, Sara Eslava-Alcón, Marta Rojas-Torres, Daniel Sánchez-Morillo, Mª Pilar Martinez-Nicolás, Victoria Martín-Bermejo, Inés García de la Torre, Esther Berrocoso, Juan Antonio Moreno, Rafael Moreno-Luna and Mª Carmen Durán-Ruiz
    Citation: Molecular Medicine 2022 28:40
    Content type: Research article Published on:

  19. Bladder cancer (BC) has the highest per-patient cost of all cancer types. Hence, we aim to develop a non-invasive, point-of-care tool for the diagnostic and molecular stratification of patients with BC based o...

    Authors: Tudor Moisoiu, Mihnea P. Dragomir, Stefania D. Iancu, Simon Schallenberg, Giovanni Birolo, Giulio Ferrero, Dan Burghelea, Andrei Stefancu, Ramona G. Cozan, Emilia Licarete, Alessandra Allione, Giuseppe Matullo, Gheorghita Iacob, Zoltán Bálint, Radu I. Badea, Alessio Naccarati…
    Citation: Molecular Medicine 2022 28:39
    Content type: Research article Published on:

  20. The diagnostic yield of whole-exome sequencing (WES) varies from 30%–50% among patients with mild to severe neurodevelopmental delay (NDD)/intellectual disability (ID). Routine retrospective reanalysis of undi...

    Authors: Go Hun Seo, Hane Lee, Jungsul Lee, Heonjong Han, You Kyung Cho, Minji Kim, Yunha Choi, Jeongmin Choi, In Hee Choi, Seonkyeong Rhie, Kyu Young Chae, Yoo-Mi Kim, Chong Kun Cheon, Su Jin Kim, Jieun Lee, Eungu Kang…
    Citation: Molecular Medicine 2022 28:38
    Content type: Research article Published on:

  21. Chronic liver injury induces pathological repair, resulting in fibrosis, during which hepatic stellate cells (HSCs) are activated and transform into myofibroblasts. CD248 is mainly expressed on myofibroblasts ...

    Authors: Shaojie Liu, Donghui Han, Chao Xu, Fa Yang, Yu Li, Keying Zhang, Xiaolong Zhao, Jiayu Zhang, Tong Lu, Shiqi Lu, Changhong Shi, Rui Zhang, An-Gang Yang, Aizhi Zhao, Weijun Qin, Bo Yang…
    Citation: Molecular Medicine 2022 28:37
    Content type: Research article Published on:

  22. Over the years, microRNAs (miRNAs) have been involved in the pathogenesis of rheumatoid arthritis (RA). We aim to investigate the role of human umbilical cord mesenchymal stem cells (HUCMSCs)-derived exosomal ...

    Authors: Yijiang Huang, Liang Chen, Daosen Chen, Pei Fan and Huachen Yu
    Citation: Molecular Medicine 2022 28:36
    Content type: Research article Published on:

  23. Authors: Carlo Calissano, Rajendra N. Damle, Sonia Marsilio, Xiao-Jie Yan, Sophia Yancopoulos, Gregory Hayes, Claire Emson, Elizabeth J. Murphy, Marc K. Hellerstein, Cristina Sison, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Ivana Ivanovic, Igor M. Dozmorov…
    Citation: Molecular Medicine 2022 28:35
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2011 17:Art28

  24. IDH-mutant astrocytoma and oligodendroglioma have an indolent natural history and are recognized as distinct entities of neoplasms. There is little knowledge on the molecular differences between IDH-mutant ast...

    Authors: Binghao Zhao, Yu Xia, Fengchun Yang, Yaning Wang, Yuekun Wang, Yadong Wang, Congxin Dai, Yu Wang and Wenbin Ma
    Citation: Molecular Medicine 2022 28:34
    Content type: Research article Published on:

  25. Long non-coding RNAs (lncRNAs) play critically in the pathogenesis of myocardial ischemia–reperfusion (I/R) injury. Thus, it was proposed to investigate the mechanism of LINC00461 in the disease through mediat...

    Authors: Feng Gao, Xiaochen Wang, Tingting Fan, Zhidan Luo, Mengqing Ma, Guangquan Hu, Yue Li, Yi Liang, Xianhe Lin and Banglong Xu
    Citation: Molecular Medicine 2022 28:33
    Content type: Research article Published on:

  26. Sepsis induces group 2 innate lymphoid cell (ILC2) expansion in the lung. However, the origin of these lung-recruited ILC2 and the mechanism of ILC2 expansion are unclear. This study aims to determine the orig...

    Authors: Dengming Lai, Weiwei Chen, Kai Zhang, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson and Jie Fan
    Citation: Molecular Medicine 2022 28:32
    Content type: Research article Published on:

  27. Caloric restriction and exercise are lifestyle interventions that effectively attenuate cardiometabolic impairment. However, cardioprotective effects of long-term lifestyle interventions and short-term lifesty...

    Authors: Chanisa Thonusin, Patcharapong Pantiya, Natticha Sumneang, Titikorn Chunchai, Wichwara Nawara, Busarin Arunsak, Natthaphat Siri-Angkul, Sirawit Sriwichaiin, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Molecular Medicine 2022 28:31
    Content type: Research article Published on:

  28. Advanced type 2 diabetes mellitus (T2DM) accelerates vascular smooth muscle cell (VSMC) dysfunction which contributes to the development of vasculopathy, associated with the highest degree of morbidity of T2DM...

    Authors: Maria Alicia Carrillo-Sepulveda, Nicole Maddie, Christina Mary Johnson, Cameron Burke, Osina Lutz, Bamwa Yakoub, Benjamin Kramer and Dhandevi Persand
    Citation: Molecular Medicine 2022 28:30
    Content type: Research article Published on:

  29. Parkinson's disease (PD) is the second most common neurodegenerative disease without cure or effective treatment. This study explores whether the yeast internal NADH-quinone oxidoreductase (NDI1) can functiona...

    Authors: Hongzhi Li, Bohao Sun, Yuting Huang, Jing Zhang, Xuejing Xu, Yuqi Shen, Zhuo Chen, Jifeng Yang, Luxi Shen, Yongwu Hu and Haihua Gu
    Citation: Molecular Medicine 2022 28:29
    Content type: Research article Published on:

  30. The underlying pathophysiology of Parkinson's disease is complex, involving different molecular pathways, including brain iron deposition and mitochondrial dysfunction. At a molecular level, these disease mech...

    Authors: Jannik Prasuhn, Martin Göttlich, Friederike Gerkan, Sofia Kourou, Britt Ebeling, Meike Kasten, Henrike Hanssen, Christine Klein and Norbert Brüggemann
    Citation: Molecular Medicine 2022 28:28
    Content type: Research article Published on:

  32. Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL. Here in this study, we investigate whether the ...

    Authors: Zhiwen Wang, Juan Chen, Zhuanglin Zeng, Qing Zhang, Gaohui Du, Xiaopeng Guo and Yumiao Wei
    Citation: Molecular Medicine 2022 28:26
    Content type: Research article Published on:

  33. Authors: Sofia Masuelli, Sebastian Real, Emanuel Campoy, Maria Teresita Branham, Diego Matias Marzese, Matthew Salomon, Gerardo De Blas, Rodolfo Arias, Michael Levin and Maria Roque
    Citation: Molecular Medicine 2022 28:25
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2022 28:15

  34. Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial proliferation and bone destruction. Adenosine deaminase (ADA) is a key inflammatory enzyme that increases joint stiff...

    Authors: Karim Samy El-Said, Amira Atta, Maysa A. Mobasher, Mousa O. Germoush, Tarek M. Mohamed and Maha M. Salem
    Citation: Molecular Medicine 2022 28:24
    Content type: Research article Published on:

  35. The inhibition of osteogenic differentiation is a major factor in glucocorticoid-induced bone loss, but there is currently no effective treatment. Dopamine, a major neurotransmitter, transmits signals via five...

    Authors: Jie Zhu, Chengcheng Feng, Weicheng Zhang, Zhidong Wang, Mengdan Zhong, Wenkai Tang, Zhifang Wang, Haiwei Shi, Zhengyu Yin, Jiandong Shi, Yu Huang, Long Xiao, Dechun Geng and Zhirong Wang
    Citation: Molecular Medicine 2022 28:23
    Content type: Research article Published on:

  36. Phosphorylation modification of BCL2 is involved in receptor activator of nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast precursors (OCPs) and osteoclastogenesis. As an antiapoptotic molecule...

    Authors: Dianshan Ke, Yunlong Yu, Chenglong Li, Junyong Han and Jie Xu
    Citation: Molecular Medicine 2022 28:22
    Content type: Research article Published on:

  37. Many clinical studies have shown a correlation between proton pump inhibitors (PPIs) and osteoporosis or fractures. The purpose of this study was to establish a murine model of chronic oral PPI administration ...

    Authors: Ziping Cheng, Yangjie Liu, Mengyuan Ma, Shiyu Sun, Zengqing Ma, Yu Wang, Liyuan Yu, Xuping Qian, Luning Sun, Xuehui Zhang, Yun Liu and Yongqing Wang
    Citation: Molecular Medicine 2022 28:21
    Content type: Research article Published on:

  38. Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized N...

    Authors: Angelica Cuapio, Caroline Boulouis, Iva Filipovic, David Wullimann, Tobias Kammann, Tiphaine Parrot, Puran Chen, Mira Akber, Yu Gao, Quirin Hammer, Benedikt Strunz, André Pérez Potti, Olga Rivera Ballesteros, Joshua Lange, Jagadeeswara Rao Muvva, Peter Bergman…
    Citation: Molecular Medicine 2022 28:20
    Content type: Research article Published on:

  39. Myocardial fibrosis after myocardial infarction (MI) is one of the leading causes of cardiovascular diseases. Cardiac fibroblasts (CFs) are activated and promoted by MI to undergo myofibroblast transformation ...

    Authors: Pengfei Chen, Junyu Pei, Xiaopu Wang, Shi Tai, Liang Tang and Xinqun Hu
    Citation: Molecular Medicine 2022 28:19
    Content type: Research article Published on:

  40. Although type 1 diabetes (T1D) is typically described as a T cell-mediated autoimmune disease, increasing evidence for a role of B cells has emerged. However, the pivotal disease-relevant B cell subset and its...

    Authors: Qing Ling, Lei Shen, Wei Zhang, DuoDuo Qu, Hongdong Wang, Bin Wang, Yong Liu, Jing Lu, Dalong Zhu and Yan Bi
    Citation: Molecular Medicine 2022 28:18
    Content type: Research article Published on:

  41. Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnorm...

    Authors: Jiliang Huang, Gaizhen Ru, Jiajia Sun, Luying Sun and Zhiling Li
    Citation: Molecular Medicine 2022 28:17
    Content type: Research article Published on:

  42. Hepatocellular carcinoma (HCC) remains one of the most common malignant tumors with poor survival. Pyroptosis is a kind of programmed cell death that can regulate the proliferation, invasion, and metastasis of...

    Authors: Min Deng, Shiquan Sun, Rongce Zhao, Renguo Guan, Zhen Zhang, Shaohua Li, Wei Wei and Rongping Guo
    Citation: Molecular Medicine 2022 28:16
    Content type: Research article Published on:

  43. During embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast tumors exhibit consistently-biased incidence, gene expression, and DNA m...

    Authors: Sofía Masuelli, Sebastián Real, Emanuel Campoy, María Teresita Branham, Diego Matías Marzese, Matthew Salomon, Gerardo De Blas, Rodolfo Arias, Michael Levin and María Roqué
    Citation: Molecular Medicine 2022 28:15
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2022 28:25

  45. Previously, we observed that hypothermia, widely used for organ preservation, elicits mitochondrial fission in different cell types. However, temperature dependence, mechanisms and consequences of this cold-in...

    Authors: Leonard Quiring, Björn Walter, Niklas Lohaus, Dhanusha Schwan, Anja Rech, Andrea Dlugos and Ursula Rauen
    Citation: Molecular Medicine 2022 28:13
    Content type: Research article Published on:

  46. The increasing incidence of non-alcoholic fatty liver disease (NAFLD) has been reported worldwide, which urges understanding of its pathogenesis and development of more effective therapeutical methods for this...

    Authors: Fei Zhao, Jinjing Ke, Wensheng Pan, Hanghai Pan and Miao Shen
    Citation: Molecular Medicine 2022 28:12
    Content type: Research article Published on:

  47. Alzheimer’s disease (AD) is the most common type of neurodegenerative disease in the contemporary era, and it is still clinically incurable. Eriodictyol, a natural flavonoid compound that is mainly present in ...

    Authors: Lin Li, Wen-Jun Li, Xiang-Ru Zheng, Qing-Long Liu, Qian Du, Yu-Jie Lai and Song-Qing Liu
    Citation: Molecular Medicine 2022 28:11
    Content type: Research article Published on:

  48. Biofilm is a community of bacteria embedded in an extracellular matrix, which can colonize different human cells and tissues and subvert the host immune reactions by preventing immune detection and polarizing ...

    Authors: Rasoul Mirzaei, Niloofar Sabokroo, Yaghoub Ahmadyousefi, Hamid Motamedi and Sajad Karampoor
    Citation: Molecular Medicine 2022 28:10
    Content type: Review Published on:

  49. Sepsis is a troublesome syndrome that can cause intestinal injury and even high mortality rates. Omega-3 fatty acids (FAs) are known to protect against intestinal damage. Accordingly, the current study set out...

    Authors: You-Lian Chen, Yin-Jing Xie, Zhen-Mi Liu, Wei-Bu Chen, Ru Zhang, Hong-Xing Ye, Wei Wang, Xue-Yan Liu and Huai-Sheng Chen
    Citation: Molecular Medicine 2022 28:9
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658