Articles

Pinocembrin mitigates depressive-like behaviors induced by chronic unpredictable mild stress through ameliorating neuroinflammation and apoptosis

The majority of patients with chronic fatigue have a risk of comorbidity with depression. Pinocembrin (PB) is a kind of flavonoid molecule isolated from honey and propolis and has antimicrobial, anti-inflammat...

Authors: Wei Wang, Lili Zheng, Lijun Xu, Jianglong Tu and Xunhu Gu

Circulating fibrocytes traffic to the lung in murine acute lung injury and predict outcomes in human acute respiratory distress syndrome: a pilot study

Fibrosis is an integral component of the pathogenesis of acute lung injury and is associated with poor outcomes in patients with acute respiratory distress syndrome (ARDS). Fibrocytes are bone marrow-derived c...

Authors: Christine M. Lin, Abdullah Alrbiaan, John Odackal, Zhimin Zhang, Yogesh Scindia, Sun-Sang J. Sung, Marie D. Burdick and Borna Mehrad

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania. There is...

Authors: Anna E. Pravednikova, Sergey Y. Shevchenko, Victor V. Kerchev, Manana R. Skhirtladze, Svetlana N. Larina, Zaur M. Kachaev, Alexander D. Egorov and Yulii V. Shidlovskii

Down-regulated miR-495 can target programmed cell death 10 in ankylosing spondylitis

MicroRNAs (miRNAs) play crucial roles in regulating eukaryotic gene expression. Recent studies indicated that aberrantly expressed miRNAs are involved in the pathogenesis of ankylosing spondylitis (AS). Indeed...

Authors: Wen-Juan Ni and Xiao-Min Leng

Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways

Pirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying ...

Authors: Qun Lv, Jianjun Wang, Changqing Xu, Xuqing Huang, Zhaoyang Ruan and Yifan Dai

An integrative investigation on significant mutations and their down-stream pathways in lung squamous cell carcinoma reveals CUL3/KEAP1/NRF2 relevant subtypes

Molecular mechanism of lung squamous cell carcinoma (LUSC) remains poorly understood, hampering effective targeted therapies or precision diagnosis about LUSC. We devised an integrative framework to investigat...

Authors: Zongang Liu, Meiyan Deng, Lin Wu and Suning Zhang

The role of adhesion protein Fibulin7 in development and diseases

Fibulins are a family of secreted glycoproteins, which play an important role in regulating multiple cellular functions such as adhesion, growth, motility, and survival. Fibulin7 (Fbln7) is expressed in develo...

Authors: Papiya Chakraborty, Shiba Prasad Dash and Pranita P. Sarangi

MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis

MicroRNAs control gene expression by post-transcriptional inhibition. Dysregulation of the expressions of miR-199a/214 cluster has been linked to cardiovascular diseases. This study aimed at identifying potent...

Authors: Yi-Ling Chen, Jiunn-Jye Sheu, Cheuk-Kwan Sun, Tien-Hung Huang, Yuan-Ping Lin and Hon-Kan Yip

SRC-2 Coactivator: a role in human metabolic evolution and disease

The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the co...

Authors: Bert W. O’Malley

MiR-543 promotes tumorigenesis and angiogenesis in non-small cell lung cancer via modulating metastasis associated protein 1

This study is aimed to explore the role of miR-543 in non-small cell lung cancer (NSCLC), and verify whether miR-543 targets metastasis associated protein 1 (MTA1) to affect tumorigenesis and angiogenesis in N...

Authors: Dawei Wang, Li Cai, Xudong Tian and Wenjun Li

Overexpression of RPN2 suppresses radiosensitivity of glioma cells by activating STAT3 signal transduction

Radiation therapy is the primary method of treatment for glioblastoma (GBM). Therefore, the suppression of radioresistance in GBM cells is of enormous significance. Ribophorin II (RPN2), a protein component of...

Authors: Changyu Li, Haonan Ran, Shaojun Song, Weisong Liu, Wenhui Zou, Bei Jiang, Hongmei Zhao and Bin Shao

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

The 2019 novel coronavirus disease (COVID-19) causes for unresolved reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to identify key pathogenic molecules in COVID-19-assoc...

Authors: Ulf Andersson, William Ottestad and Kevin J. Tracey

Hydrogen peroxide and disease: towards a unified system of pathogenesis and therapeutics

Although the immune response has a prominent role in the pathophysiology of ulcerative colitis, sepsis, and systemic lupus erythematosus, a primary immune causation has not been established to explain the path...

Authors: Jay Pravda

EEG-IP: an international infant EEG data integration platform for the study of risk and resilience in autism and related conditions

Establishing reliable predictive and diganostic biomarkers of autism would enhance early identification and facilitate targeted intervention during periods of greatest plasticity in early brain development. Hi...

Authors: Stefon van Noordt, James A. Desjardins, Scott Huberty, Lina Abou-Abbas, Sara Jane Webb, April R. Levin, Sidney J. Segalowitz, Alan C. Evans and Mayada Elsabbagh

The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer

Ovarian cancer is the most lethal gynecologic cancer. Chemoresistance, especially platinum-resistance, is closely related to metastasis of ovarian cancer, however, the molecular basis by which links chemoresis...

Authors: Qi Zhang, Guifang Yan, Juan Lei, Yu Chen, Ting Wang, Juan Gong, Yong Zhou, Huakan Zhao, Hao Chen, Yu Zhou, Lei Wu, Jiangang Zhang, Xiao Zhang, Jingchun Wang and Yongsheng Li

Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2

Propofol is an intravenous anesthetic agent that commonly induces significant neuroapoptosis. MicroRNAs (miRNAs) have been reported to participate in the regulation of propofol exposure-mediated neurotoxicity....

Authors: Fang Tang, Lili Zhao, Qi Yu, Tianyin Liu, Hongyan Gong, Zhiyi Liu and Qing Li

Neonatal hair profiling reveals a metabolic phenotype of monochorionic twins with selective intrauterine growth restriction and abnormal umbilical artery flow

Selective intrauterine fetal growth restriction (sIUGR) in monochorionic diamniotic twins, especially types 2&3 with abnormal umbilical artery Doppler, results in increased risk of fetal/perinatal mortality an...

Authors: Jing Yang, Yuan Wei, Hongbo Qi, Nanlin Yin, Yang Yang, Zailing Li, Lili Xu, Xueju Wang, Pengbo Yuan, Luyao Li, Ting-Li Han and Yangyu Zhao

Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo

HDAC4 is a key regulator of chondrocyte hypertrophy and skeletal development, but it is not clear whether the increase in vascular invasion at growth plates is related to HDAC4 expression. To determine it, we ...

Authors: Lilan Gao, Shengchun Li, Xiaochun Wei, Guoqing Du, Dennis Wei and Lei Wei

Antibody development for preventing the human respiratory syncytial virus pathology

Human respiratory syncytial virus (hRSV) is the most important etiological agent causing hospitalizations associated with respiratory diseases in children under 5 years of age as well as the elderly, newborns ...

Authors: Jorge A. Soto, Nicolás M. S. Gálvez, Gaspar A. Pacheco, Susan M. Bueno and Alexis M. Kalergis

Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s disease

Macrophage Migration Inhibitory Factor (MIF) is a potent proinflammatory cytokine that promotes the production of other immune mediators. MIF is produced by most cell types in the brain including microglia, as...

Authors: Elham Nasiri, Roman Sankowski, Henriette Dietrich, Aikaterini Oikonomidi, Patricio T. Huerta, Julius Popp, Yousef Al-Abed and Michael Bacher

Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression

The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism.

Authors: Chunhui Meng, Yan Zou, Weiwei Hong, Chunhua Bao and Xiaofeng Jia

Vitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line

Vitamin D deficiency increases the risk of developing multiple sclerosis (MS) but it is unclear whether vitamin D supplementation improves the clinical course of MS, and there is uncertainty about the dose and...

Authors: Manuela Mengozzi, Andrew Hesketh, Giselda Bucca, Pietro Ghezzi and Colin P. Smith

microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway

Accumulating evidence has implicated the regulation of microRNAs (miRs) in ischemia stroke. The current study aimed to elucidate the role of microRNA-195 (miR-195) in neuronal apoptosis and brain plasticity in...

Authors: Lisha Chang, Wan Zhang, Songxin Shi, Yanbo Peng, Dali Wang, Li Zhang and Jiang Zhang

Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, which threats peoples’ health. Unfortunately, the pathogenesis of PDAC remains unclear. Recent studies have indicated th...

Authors: Jing Wang, Lei Zhao, Kun Shang, Fang Liu, Juanjuan Che, Huihui Li and Bangwei Cao

circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling

Glioma has the characteristics of high incidence and mortality, and is a common malignant tumor of the central nervous system. Circular RNAs (circRNAs) have been reported to play vital roles in progression of ...

Authors: Long-Wei Huo, Ya-Fei Wang, Xiao-Bin Bai, Hu-Lin Zheng and Mao-De Wang

Shikonin suppresses NEAT1 and Akt signaling in treating paclitaxel-resistant non-small cell of lung cancer

The development of paclitaxel-resistance led to the tumor relapse and treatment failure of non-small cell lung cancer. Shikonin has been demonstrated to show anti-cancer activity in many cancer types. The pres...

Authors: Farong Zang, Yuanquan Rao, Xinhai Zhu, Zhibing Wu and Hao Jiang

TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin α5 pathway

Tissue factor pathway inhibitor 2 (TFPI2) participates in carcinogenesis of various tumors, and is associated with poor survival of breast cancer patients. However, the effect and underlying mechanism of TFPI2...

Authors: Danyi Zhao, Jingjing Qiao, Hongmei He, Jincheng Song, Shanshan Zhao and Jing Yu

LncRNA HULC induces the progression of osteosarcoma by regulating the miR-372-3p/HMGB1 signalling axis

Osteosarcoma is a malignancy that normally affects children, adolescents, and young adults. Although accumulating evidence has demonstrated the importance of HULC in osteosarcoma, little is reported about its ...

Authors: Yong Li, Jing-Jing Liu, Jia-Hui Zhou, Rui Chen and Chao-Qun Cen

Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach

B cell receptor Immunoglobulin (BcR IG) repertoire of Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of quasi-identical BcR IG. These are observed in approximately 30% of patients, defin...

Authors: Monica Colombo, Davide Bagnara, Daniele Reverberi, Serena Matis, Martina Cardillo, Rosanna Massara, Luca Mastracci, Jean Louis Ravetti, Luca Agnelli, Antonino Neri, Michela Mazzocco, Margherita Squillario, Andrea Nicola Mazzarello, Giovanna Cutrona, Andreas Agathangelidis, Kostas Stamatopoulos…

Upregulation of the transcription factor TFAP2D is associated with aggressive tumor phenotype in prostate cancer lacking the TMPRSS2:ERG fusion

TFAP2D is a transcription factor important for modulating gene expression in embryogenesis. Its expression and prognostic role in prostate cancer has not been evaluated.

Authors: Christoph Fraune, Luisa Harms, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Katharina Möller, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Guido Sauter, Sören Weidemann, Patrick Lebok, David Dum…

Digital imaging-assisted quantification of H3K27me3 immunoexpression in luminal A/B-like, HER2-negative, invasive breast cancer predicts patient survival and risk of recurrence

Breast cancer (BC) is a major health concern and better understanding of its biology might improve treatment decisions and patient outcomes. Histone3 Lysine27 tri-methylation (H3K27me3) is a post-translational...

Authors: Mário Fontes-Sousa, João Lobo, Silvana Lobo, Sofia Salta, Maria Amorim, Paula Lopes, Luís Antunes, Susana Palma de Sousa, Rui Henrique and Carmen Jerónimo

D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1

D-allose was promising in the protection of ischemia/reperfusion (I/R) injury. We intended to investigate the function of D-allose in skin flap of rat followed by the injury of I/R and whether ERK signal pathw...

Authors: Jihui Ju, Ruixing Hou and Ping Zhang

The role of RICTOR amplification in targeted therapy and drug resistance

The emergence of tyrosine kinase inhibitors (TKIs) has changed the current treatment paradigm and achieved good results in recent decades. However, an increasing number of studies have indicated that the compl...

Authors: Deze Zhao, Man Jiang, Xiaochun Zhang and Helei Hou

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

The serine protease KLK12 belongs to the human fifteen-member family of kallikrein-related peptidases. Differential expression accompanied by either increased or decreased enzymatic activity has been linked to...

Authors: Weiwei Gong, Yueyang Liu, Sarah Preis, Xiaocong Geng, Agnes Petit-Courty, Marion Kiechle, Alexander Muckenhuber, Tobias Dreyer, Julia Dorn, Yves Courty and Viktor Magdolen

Expression of Concern to: Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)

Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine

Expression of concern to: High systematic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome

Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter, Daniel J. Antoine and Ulf Andersson

Expression of Concern to: The α7 nicotine acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

The Editors-in-Chief would like to alert readers that this article (Sitapara et al. 2014) is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the...

Authors: Ravikumar A. Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek S. Patel, Charles R. Ashby Jr, Samir Gorasiya, Huan Yang, Michelle Zur and Lin L. Mantell

Cardioprotective effects of genetically engineered cardiac stem cells by spheroid formation on ischemic cardiomyocytes

Sca-1+ cardiac stem cells and their limited proliferative potential were major limiting factors for use in various studies.

Authors: Han Saem Jeong, Chi-Yeon Park, Jong-Ho Kim, Hyung Joon Joo, Seung-Cheol Choi, Ji-Hyun Choi, I-Rang Lim, Jae Hyoung Park, Soon Jun Hong and Do-Sun Lim

Aspirin has a better effect on PIK3CA mutant colorectal cancer cells by PI3K/Akt/Raptor pathway

Aspirin, as a non-steroidal anti-inflammatory drug, can improve the survival rate of patients with colorectal cancer, while aspirin is effective in patients with PIK3CA mutant colorectal cancer (CRC). However,...

Authors: Zhihang Chen, Chun Wang, Hao Dong, Xing Wang, Feng Gao, Sen Zhang and Xiaolong Zhang

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

The Editors-in-Chief would like to alert readers that this article [1] is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Live...

Authors: Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty and B. Kevin Park

NGF (−198C > T, Ala35Val) and p75^NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

Neural growth factor (NGF) is a neurotrophin that can interact with the p75^NTR receptor and initiate a cascade of reactions that determines cell survival or death, and both are associated with the physiology of l...

Authors: Leonn Mendes Soares Pereira, Ednelza da Silva Graça Amoras, Simone Regina Souza da Silva Conde, Sâmia Demachki, Eduardo José Melo dos Santos, Sandra Souza Lima, Ricardo Ishak and Antonio Carlos Rosário Vallinoto

The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population

Genetic variants play a critical role in the development of breast cancer. This investigation aimed to explore the association between CASC16 polymorphisms and breast cancer susceptibility.

Authors: Xiaoxiao Zuo, Huanhuan Wang, Yin Mi, Yue Zhang, Xiaofei Wang, Ya Yang and Suna Zhai

The mitohormetic response as part of the cytoprotection mechanism of berberine

It was well-known that Berberine, a major bioactive compound extracted from natural plants Coptis chinensis, has anti-diabetic effects for decades in china. Other types of pharmacological activities, such as anti...

Authors: Xiaofei Zhu, Yihui Wei, Beibei Yang, Xiaoxiao Yin and Xiaofang Guo

Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious pulmonary diseases that contain common and unique characteristics. Therefore, the identification ...

Authors: Mazaher Maghsoudloo, Sadegh Azimzadeh Jamalkandi, Ali Najafi and Ali Masoudi-Nejad

Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis

Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of biochemis...

Authors: Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Dimitrios P. Bogdanos, Piotr Milkiewicz and Malgorzata Milkiewicz

Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study

Previous studies have found ischemic stroke is associated with atrial fibrillation. However, the causal association between ischemic stroke and atrial fibrillation is not clear. Furthermore, the network relati...

Authors: Lei Hou, Mingqing Xu, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Lu Liu, Yunxia Li, Tonghui Yuan, Wenchao Li, Hongkai Li and Fuzhong Xue

Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis

The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patt...

Authors: Zachary Mostel, Abraham Perl, Matthew Marck, Syed F. Mehdi, Barbara Lowell, Sagar Bathija, Ramchandani Santosh, Valentin A. Pavlov, Sangeeta S. Chavan and Jesse Roth

HMGB1 concentration measurements in trauma patients: assessment of pre-analytical conditions and sample material

HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, d...

Authors: William Ottestad, Ingrid N. Rognes, Erlend Skaga, Cassandra Frisvoll, Guttorm Haraldsen, Torsten Eken and Peter Lundbäck

Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape

The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in t...

Authors: Reham M. Milhem and Bassam R. Ali

Inhibition of microRNA-29a alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice via upregulation of GAB1

The main features of bronchopulmonary dysplasia (BPD) are alveolar simplification, pulmonary growth arrest, and abnormal lung function. Multiple studies have highlighted microRNA-29 (miR-29) as a potential bio...

Authors: Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou and Hanmin Liu