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  1. Content type: Research article

    Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/...

    Authors: Qicai Liu, Ling Guo, Sheng Zhang, Jingwen Wang, Xinhua Lin and Feng Gao

    Citation: Molecular Medicine 2019 25:44

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  2. Content type: Research article

    The protective effect of melatonin against bone metabolism imbalance in osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this study was to explore the role of melatonin in b...

    Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang

    Citation: Molecular Medicine 2019 25:43

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  3. Content type: Research article

    HER2 is considered as one of the most important, predictive biomarkers in oncology. The diagnosis of HER2 positive cancer types such as breast- and gastric cancer is usually based on immunohistochemical HER2 s...

    Authors: Diana B. Peckys, Daniela Hirsch, Timo Gaiser and Niels de Jonge

    Citation: Molecular Medicine 2019 25:42

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  4. Content type: Research article

    Peritoneal fibrosis (PF) represents a long-term complication of peritoneal dialysis (PD), affecting peritoneal membrane (PM) integrity and function. Understanding the mechanisms underlying PF development in an...

    Authors: Filipe M. O. Silva, Elerson C. Costalonga, Cleonice Silva, Ana C. O. Carreira, Samirah A. Gomes, Mari C. Sogayar, Camilla Fanelli and Irene L. Noronha

    Citation: Molecular Medicine 2019 25:41

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  5. Content type: Research article

    Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. ...

    Authors: Takashi Tani, Ken Okamoto, Megumi Fujiwara, Akira Katayama and Shuichi Tsuruoka

    Citation: Molecular Medicine 2019 25:40

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  6. Content type: Research article

    Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammato...

    Authors: Marie Hilderman, Abdul Rashid Qureshi, Farhad Abtahi, Nils Witt, Christina Jägren, Joakim Olbers, Martin Delle, Kaj Lindecrantz and Annette Bruchfeld

    Citation: Molecular Medicine 2019 25:39

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  7. Content type: Research article

    Early distinction between refractory M. pneumoniae pneumonia (RMPP) and non-RMPP (NRMPP) is still difficult. The community-acquired respiratory distress syndrome (CARDS) toxin can induce inflammatory and histopat...

    Authors: Gang Li, Liping Fan, Yuqing Wang, Li Huang, Meijuan Wang, Canhong Zhu, Chuangli Hao, Wei Ji, Hansi Liang, Yongdong Yan and Zhengrong Chen

    Citation: Molecular Medicine 2019 25:38

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  8. Content type: Short report

    Human reproductive disorders consist of frequently occurring dysfunctions including a broad range of phenotypes affecting fertility and women’s health during pregnancy. Several female-related diseases have bee...

    Authors: Paula Quintero-Ronderos, Karen Marcela Jiménez, Clara Esteban-Pérez, Diego A. Ojeda, Sandra Bello, Dora Janeth Fonseca, María Alejandra Coronel, Harold Moreno-Ortiz, Diana Carolina Sierra-Díaz, Elkin Lucena, Sandrine Barbaux, Daniel Vaiman and Paul Laissue

    Citation: Molecular Medicine 2019 25:37

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  9. Content type: Research article

    Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children and Glucocorticoids (GCs) form an essential component of the standard chemotherapy in most treatment regimens. The cat...

    Authors: Zaynab Mousavian, Abbas Nowzari-Dalini, Yasir Rahmatallah and Ali Masoudi-Nejad

    Citation: Molecular Medicine 2019 25:36

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  10. Content type: Research article

    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose onset and progression are affected by genetic and environmental factors. The purpose of this study is to identify the influence of gut m...

    Authors: Yiyangzi Ma, Xiaoxue Xu, Mengtao Li, Jun Cai, Qiang Wei and Haitao Niu

    Citation: Molecular Medicine 2019 25:35

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  11. Content type: Correction

    Following publication of the original article [1], the author reported an error in Figure 1. The correct version of Figure 1 is as follows:

    Authors: Vijay K. Sonkar, Paresh P. Kulkarni, Susheel N. Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata Dash

    Citation: Molecular Medicine 2019 25:34

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    The original article was published in Molecular Medicine 2016 22:2201224

  12. Content type: Research article

    The beneficial effects of angiotensin II type 1 receptor blockers (ARBs) on atherosclerosis have been demonstrated in numerous studies. We investigated the effects of fimasartan on reducing neointimal formatio...

    Authors: Jong-Ho Kim, I-Rang Lim, Hyung Joon Joo, Chi-Yeon Park, Seung-Cheol Choi, Han Saem Jeong and Soon Jun Hong

    Citation: Molecular Medicine 2019 25:33

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  13. Content type: Research article

    Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the...

    Authors: Junling Zhao, Hsiao Tung Yang, Lakmini Wasala, Keqing Zhang, Yongping Yue, Dongsheng Duan and Yi Lai

    Citation: Molecular Medicine 2019 25:31

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  14. Content type: Research article

    Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume ...

    Authors: Ali Khosravi, B. Jayaram, Bahram Goliaei and Ali Masoudi-Nejad

    Citation: Molecular Medicine 2019 25:30

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  15. Content type: Research article

    Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of L...

    Authors: Yuya Asanomi, Daichi Shigemizu, Akinori Miyashita, Risa Mitsumori, Taiki Mori, Norikazu Hara, Kaoru Ito, Shumpei Niida, Takeshi Ikeuchi and Kouichi Ozaki

    Citation: Molecular Medicine 2019 25:20

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  16. Content type: Research article

    Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immu...

    Authors: Cheng Zhang, Feng Chen, Li Feng, Qun Shan, Gui-Hong Zheng, Yong-Jian Wang, Jun Lu, Shao-Hua Fan, Chun-Hui Sun, Dong-Mei Wu, Meng-Qiu Li, Bin Hu, Qing-Qing Wang, Zi-Feng Zhang and Yuan-Lin Zheng

    Citation: Molecular Medicine 2019 25:29

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  17. Content type: Research article

    Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology with only two federally approved drug options. Given the complex molecular pathogenesis of IPF involving multiple cell types and ...

    Authors: L. R. Rodriguez, S. N. Bui, R. T. Beuschel, E. Ellis, E. M. Liberti, M. K. Chhina, B. Cannon, M. Lemma, S. D. Nathan and G. M. Grant

    Citation: Molecular Medicine 2019 25:27

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  18. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-12...

    Authors: Jun-Ke Long, Wen Dai, Ya-Wen Zheng and Shui-Ping Zhao

    Citation: Molecular Medicine 2019 25:26

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  19. Content type: Short report

    Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build a...

    Authors: Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Li Jin, Hejian Zou, Shifang Ren and Jiucun Wang

    Citation: Molecular Medicine 2019 25:25

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  20. Content type: Research article

    Alcohol abuse affects the brain regions responsible for memory, coordination and emotional processing. Binge alcohol drinking has shown reductions in brain activity, but the molecular targets have not been com...

    Authors: Asha Jacob, Yilong Ma, Elham Nasiri, Mahendar Ochani, Joseph Carrion, Shichun Peng, Max Brenner, Patricio T. Huerta and Ping Wang

    Citation: Molecular Medicine 2019 25:24

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  21. Content type: Research article

    Cervical cancer is the third most common gynecological malignancy. Conventional treatment options are known to be ineffective for the majority of patients with advanced or recurrent cervical cancer. Therefore,...

    Authors: Sungha Lee, Jung Yoon Ho, Jing Jing Liu, Hyewon Lee, Jae Young Park, Minwha Baik, Minji Ko, Seon Ui Lee, Youn Jin Choi and Soo Young Hur

    Citation: Molecular Medicine 2019 25:23

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  22. Content type: Research article

    Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition ...

    Authors: Tao Jiang, Meiyan Wu, Zhanqin Zhang, Chaoying Yan, Zhi Ma, Shan He, Wei Yuan, Kairui Pu and Qiang Wang

    Citation: Molecular Medicine 2019 25:22

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  23. Content type: Research article

    Metabolic memory contributes to the development of diabetic retinopathy (DR), which is the complication of diabetes. But it’s still unknown how to prevent the metabolic memory to treat the DR. In our study, we...

    Authors: Ping Liu, Qing-Hua Peng, Ping Tong and Wen-Jie Li

    Citation: Molecular Medicine 2019 25:21

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  24. Content type: Research article

    The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their per...

    Authors: Amol Kolte and Rainer König

    Citation: Molecular Medicine 2019 25:19

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  25. Content type: Research article

    Acute myocardial infarction (AMI) was considered to be one of the major causes of morbidity and mortality worldwide. In order to manage the acute myocardial infarction outbreaks, accurate biomarkers for risk p...

    Authors: Sheng Xue, Wenjie Zhu, Dacheng Liu, Zhe Su, Liwei Zhang, Qing Chang and Peifeng Li

    Citation: Molecular Medicine 2019 25:18

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  26. Content type: Research article

    Obesity is one of the leading causes of insulin resistance. Accumulating reports have highlighted that serum amyloid A-1 (SAA1) is a potential candidate that is capable of attenuating insulin resistance. Hence...

    Authors: Yong Wang, Feng Cao, Yang Wang, Gang Yu and Ben-Li Jia

    Citation: Molecular Medicine 2019 25:17

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  27. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide. Inflammation plays an important role in disease pathogenesis and recent studies have shown a potential role for the neutr...

    Authors: Andreea-Manuela Mirea, Erik J. M. Toonen, Inge van den Munckhof, Isabelle D. Munsterman, Eric T. T. L. Tjwa, Martin Jaeger, Marije Oosting, Kiki Schraa, Joost H. W. Rutten, Marinette van der Graaf, Niels P. Riksen, Jacqueline de Graaf, Mihai G. Netea, Cees J. Tack, Triantafyllos Chavakis and Leo A. B. Joosten

    Citation: Molecular Medicine 2019 25:16

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  28. Content type: Research article

    The demonstration of EGFR T790M gene mutation in plasma is crucial to assess the eligibility of Non Small Cell Lung Cancer (NSCLC) patients, who have acquired resistance to first or second generation Tyrosine Kin...

    Authors: Mariella Dono, Giuseppa De Luca, Sonia Lastraioli, Giorgia Anselmi, Maria Giovanna Dal Bello, Simona Coco, Irene Vanni, Francesco Grossi, Antonella Vigani, Carlo Genova, Manlio Ferrarini, Jean Louis Ravetti and Simona Zupo

    Citation: Molecular Medicine 2019 25:15

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  29. Content type: Research article

    Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations. Although the aetiology of CFS/ME remains elusive, immunolo...

    Authors: H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines and S. Marshall-Gradisnik

    Citation: Molecular Medicine 2019 25:14

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  30. Content type: Research article

    Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for ...

    Authors: Huan Yang, Hui Liu, Qiong Zeng, Gavin H. Imperato, Meghan E. Addorisio, Jianhua Li, Mingzhu He, Kai Fan Cheng, Yousef Al-Abed, Helena E. Harris, Sangeeta S. Chavan, Ulf Andersson and Kevin J. Tracey

    Citation: Molecular Medicine 2019 25:13

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  31. Content type: Research article

    The polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we exa...

    Authors: Kim R. Simpfendorfer, Nancy Wang, Dedreia L. Tull, David P. De Souza, Amsha Nahid, Andre Mu, Dianna M. Hocking, John S. Pedersen, Odilia L. C. Wijburg, Malcolm J. McConville and Richard A. Strugnell

    Citation: Molecular Medicine 2019 25:12

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  32. Content type: Research article

    Endometrial carcinoma represents one of the most common cancer types of the female reproductive tract. If diagnosed at an early stage, the 5-year survival rate is promising. However, recurrence and chemoresist...

    Authors: Jing-Wei Zhou, Juan-Juan Tang, Wei Sun and Hui Wang

    Citation: Molecular Medicine 2019 25:11

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  33. Content type: Research article

    The pathological features of aortic dissection (AD) include vascular smooth muscle cell (VSMC) loss, elastic fiber fraction, and inflammatory responses in the aorta. However, little is known about the post-tra...

    Authors: Xian Guo, Ze-Min Fang, Xiang Wei, Bo Huo, Xin Yi, Cai Cheng, Jun Chen, Xue-Hai Zhu, Anas Omar Khalil Abu Bokha and Ding-Sheng Jiang

    Citation: Molecular Medicine 2019 25:10

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  34. Content type: Research article

    Cell therapy is proposed to be a potential treatment for Parkinson’s disease (PD). Although fetal retinal pigment epithelial (RPE) cells have been tested in trials for treating PD patients, controversy has bee...

    Authors: Sha Li, Han Zhang, Aifang Wang, Yan Liu, Houqi Liu, Feng Yue, Xianmixinuer Abulaiti, Caiqiao Zhang and Lingsong Li

    Citation: Molecular Medicine 2019 25:9

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  35. Content type: Research article

    2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure (HF), but its effect on short-term adverse outcomes in patients with acu...

    Authors: Zhengliang Peng, Qiong Zhan, Xiangkun Xie, Hanlin Li, Yan Tu, Yujia Bai, Xingfu Huang, Wenyan Lai, Boxin Zhao, Qingchun Zeng and Dingli Xu

    Citation: Molecular Medicine 2019 25:8

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  36. Content type: Research article

    Long non-coding RNAs (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been shown to be associated with liver fibrosis. Nevertheless, the role of PVT1 in atrial fibrosis remains undefined. This study ai...

    Authors: Feng Cao, Zhe Li, Wen-mao Ding, Ling Yan and Qing-yan Zhao

    Citation: Molecular Medicine 2019 25:7

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  37. Content type: Research article

    Deleterious variants in the voltage-gated sodium channel type 2 (Nav1.2) lead to a broad spectrum of phenotypes ranging from benign familial neonatal-infantile epilepsy (BFNIE), severe developmental and epileptic...

    Authors: Anaïs Begemann, Mario A. Acuña, Markus Zweier, Marie Vincent, Katharina Steindl, Ruxandra Bachmann-Gagescu, Annette Hackenberg, Lucia Abela, Barbara Plecko, Judith Kroell-Seger, Alessandra Baumer, Kazuhiro Yamakawa, Yushi Inoue, Reza Asadollahi, Heinrich Sticht, Hanns Ulrich Zeilhofer…

    Citation: Molecular Medicine 2019 25:6

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  38. Content type: Research article

    Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the...

    Authors: Wen-Chih Chiang, Yu-Chin Huang, Ten-I Fu, Ping-Min Chen, Fan-Chi Chang, Chun-Fu Lai, Vin-Cent Wu, Shuei-Liong Lin and Yung-Ming Chen

    Citation: Molecular Medicine 2019 25:5

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  39. Content type: Research article

    Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible ...

    Authors: Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll and Alex F. de Vos

    Citation: Molecular Medicine 2019 25:3

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  40. Content type: Research article

    Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Here, we sought to investigate the glucose metabolism characteristics of SUR1−/− rats.

    Authors: Xiaojun Zhou, Chunmei Xu, Zhiwei Zou, Xue Shen, Tianyue Xie, Rui Zhang, Lin Liao and Jianjun Dong

    Citation: Molecular Medicine 2019 25:2

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  41. Content type: Research article

    Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to invest...

    Authors: Rose A. Willemze, Olaf Welting, Patricia van Hamersveld, Caroline Verseijden, Laurens E. Nijhuis, Francisca W. Hilbers, Sybren L. Meijer, Balthasar A. Heesters, Joost H. A. Folgering, Harold Darwinkel, Philippe Blancou, Margriet J. Vervoordeldonk, Jurgen Seppen, Sigrid E. M. Heinsbroek and Wouter J. de Jonge

    Citation: Molecular Medicine 2019 25:1

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  42. Content type: Research

    Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate c...

    Authors: Yiting Tang, Rui Zhang, Qianqian Xue, Ran Meng, Xiangyu Wang, Yanliang Yang, Lingli Xie, Xianzhong Xiao, Timothy R. Billiar and Ben Lu

    Citation: Molecular Medicine 2018 24:66

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  43. Content type: Research article

    Numerous host cellular factors are exploited by viruses to facilitate infection. Our previous studies and those of others have shown heat-shock protein 90 (Hsp90), a cellular molecular chaperone, is involved i...

    Authors: Yiliang Wang, Rongze Wang, Feng Li, Yun Wang, Zhen Zhang, Qiaoli Wang, Zhe Ren, Fujun Jin, Kaio Kitazato and Yifei Wang

    Citation: Molecular Medicine 2018 24:65

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  44. Content type: Research article

    The multiple biological effects of vitamin D and its novel activities on inflammation and redox homeostasis have raised high expectations on its use as a therapeutic agent for multiple fibrogenic conditions. W...

    Authors: Trinidad Guijarro, Esmeralda Magro-Lopez, Joana Manso, Ricardo Garcia-Martinez, Maria Jesus Fernandez-Aceñero, Isabel Liste and Alberto Zambrano

    Citation: Molecular Medicine 2018 24:64

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  45. Content type: Research article

    Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought t...

    Authors: Rafael Y. Brzezinski, Eyal Fisher, Noa Cohen, Etti Zwang, Gabi Shefer, Naftali Stern, David Zeltser, Itzhak Shapira, Shlomo Berliner, Ori Rogowski and Shani Shenhar-Tsarfaty

    Citation: Molecular Medicine 2018 24:63

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  46. Content type: Research article

    Gold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown. The aim of this study is to explore the effect of AuN...

    Authors: Hui Yang, Libo Du, Guangjun Wu, Zhenyu Wu and Jeffrey A. Keelan

    Citation: Molecular Medicine 2018 24:62

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  47. Content type: Research article

    There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD)...

    Authors: Yue Dong, Li-Li Han and Zhong-Xin Xu

    Citation: Molecular Medicine 2018 24:61

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