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  1. Diffuse large B cell lymphoma (DLBCL) is an aggressive and molecularly heterogeneous non-Hodgkin’s lymphoma. The B cell receptor (BCR) signaling pathway in DLBCL emerges as a new drug target. Protein phosphata...

    Authors: Ji-Lin Chen, Pei-Yi Chu, Chun-Teng Huang, Tzu-Ting Huang, Wan-Lun Wang, Yu-Hsuan Lee, Yuan-Ya Chang, Ming-Shen Dai, Chung-Wai Shiau and Chun-Yu Liu
    Citation: Molecular Medicine 2022 28:93
    Content type: Research article Published on:

  2. The forkhead box O3a protein (FoxO3a) has been reported to be involved in the migration and invasion of trophoblast, but its underlying mechanisms unknown. In this study, we aim to explore the transcriptional ...

    Authors: Hao Chen, Shi-Han Wang, Chang Chen, Xin-Yang Yu, Jia-Nan Zhu, Toby Mansell, Boris Novakovic, Richard Saffery, Philip N. Baker, Ting-Li Han and Hua Zhang
    Citation: Molecular Medicine 2022 28:92
    Content type: Research article Published on:

  3. Neutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and fungal infection. However, accumulation of activated neutrophils can ca...

    Authors: Satoshi Takizawa, Yongchan Lee, Asha Jacob, Monowar Aziz and Ping Wang
    Citation: Molecular Medicine 2022 28:91
    Content type: Research article Published on:

  4. Myoclonus, Epilepsy and Ragged-Red-Fibers (MERRF) is a mitochondrial encephalomyopathy due to heteroplasmic mutations in mitochondrial DNA (mtDNA) most frequently affecting the tRNALys gene at position m.8344A > ...

    Authors: Mariantonietta Capristo, Valentina Del Dotto, Concetta Valentina Tropeano, Claudio Fiorini, Leonardo Caporali, Chiara La Morgia, Maria Lucia Valentino, Monica Montopoli, Valerio Carelli and Alessandra Maresca
    Citation: Molecular Medicine 2022 28:90
    Content type: Research article Published on:

  6. Kidney stones are composed of approximately 70–80% calcium oxalate. However, the exact mechanism of formation of calcium oxalate kidney stones remains unclear. In this study, we investigated the roles of endop...

    Authors: Shaoxiong Ming, Jia Tian, Ke Ma, Chengbin Pei, Ling Li, Zeyu Wang, Ziyu Fang, Min Liu, Hao Dong, Weijian Li, Jianwen Zeng, Yonghan Peng and Xiaofeng Gao
    Citation: Molecular Medicine 2022 28:88
    Content type: Research article Published on:

  7. Angiogenesis plays a critical role on post-infarction heart failure (PIHF), the presence of which facilitates additional blood supply to maintain the survival of residual cardiomyocytes. The sigma-1 receptor (...

    Authors: Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu and Bo Yang
    Citation: Molecular Medicine 2022 28:87
    Content type: Research article Published on:

  8. Regardless of improvements in controlling the COVID-19 pandemic, the lack of comprehensive insight into SARS-COV-2 pathogenesis is still a sophisticated challenge. In order to deal with this challenge, we util...

    Authors: Samaneh Maleknia, Mohammad Javad Tavassolifar, Faezeh Mottaghitalab, Mohammad Reza Zali and Anna Meyfour
    Citation: Molecular Medicine 2022 28:86
    Content type: Research article Published on:

  9. Uncontrolled inflammation is an important factor in the occurrence and development of acute lung injury (ALI). Fibroblast growth factor-inducible 14 (Fn14), a plasma membrane-anchored receptor, takes part in t...

    Authors: Xin-Xin Guan, Hui-Hui Yang, Wen-Jing Zhong, Jia-Xi Duan, Chen-Yu Zhang, Hui-Ling Jiang, Yang Xiang, Yong Zhou and Cha-Xiang Guan
    Citation: Molecular Medicine 2022 28:85
    Content type: Research article Published on:

  10. Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways enforces limits th...

    Authors: Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gaßler and Adrian T. Press
    Citation: Molecular Medicine 2022 28:84
    Content type: Review Published on:

  11. Exposure to anesthesia in the elderly might increase the risk of dementia. Although the mechanism underlying the association is uncertain, anesthesia has been shown to induce acute tau hyperphosphorylation in ...

    Authors: John David Eun, Heidy Jimenez, Leslie Adrien, Adam Wolin, Philippe Marambaud, Peter Davies and Jeremy L. Koppel
    Citation: Molecular Medicine 2022 28:83
    Content type: Research article Published on:

  12. Metastasis of malignant tumors accelerates systemic failure and hastens the deaths of pancreatic cancer patients. During the metastatic process, the physical translocation of cancer cells from the primary lesi...

    Authors: Zhongbo Zhang and Yuanhong Xu
    Citation: Molecular Medicine 2022 28:82
    Content type: Research article Published on:

  14. Liver fibrosis is a progressive liver injury response. Transforming growth factor β1 (TGF-β1) is oversecreted during liver fibrosis and promotes the development of liver fibrosis. Therapeutic approaches target...

    Authors: Xudong Song, Jiayi Shi, Jieting Liu, Yong Liu, Yang Yu, Yufei Qiu, Zhiqin Cao, Yu Pan, Xiaohuan Yuan, Yanhui Chu and Dan Wu
    Citation: Molecular Medicine 2022 28:80
    Content type: Research article Published on:

  15. Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N6-methyladenosine (m6A), the most abundant...

    Authors: Shiyi Qin, Qi Zhang, Yanhua Xu, Shuo Ma, Tianyi Wang, Yuejiao Huang and Shaoqing Ju
    Citation: Molecular Medicine 2022 28:79
    Content type: Review Published on:

  16. Angiogenesis plays the critical roles in promoting tumor progression, aggressiveness, and metastasis. Although few studies have revealed some angiogenesis-related genes (ARGs) could serve as prognosis-related ...

    Authors: Cheng-Yuan Gu, Bo Dai, Yao Zhu, Guo-Wen Lin, Hong-Kai Wang, Ding-Wei Ye and Xiao-Jian Qin
    Citation: Molecular Medicine 2022 28:78
    Content type: Research article Published on:

  17. Postoperative cognitive dysfunction induced by anesthetics commonly occurs in elderly patients. This study aimed to evaluate the protective role of trametenolic acid B (TAB) in sevoflurane-induced cognitive im...

    Authors: Jun Chen, Shuo Feng, Linyan Li, Shujie Qiu, Yanwu Jin and Yingui Sun
    Citation: Molecular Medicine 2022 28:77
    Content type: Research article Published on:

  18. Axonal regeneration following peripheral nerve injury (PNI) depends on the complex interaction between Schwann cells (SCs) and macrophages, but the mechanisms underlying macrophage recruitment and activation i...

    Authors: Gang Yin, Yaofa Lin, Peilin Wang, Jun Zhou and Haodong Lin
    Citation: Molecular Medicine 2022 28:76
    Content type: Research article Published on:

  19. Probucol (PBC) is a potent cholesterol-lowering drug and has been studied extensively for its powerful antioxidative stress. The purpose of this study is to investigate the role of PBC in ovariectomized rat mo...

    Authors: Zhou-Shan Tao, Tian-Lin Li and Shan Wei
    Citation: Molecular Medicine 2022 28:75
    Content type: Research article Published on:

  20. Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncog...

    Authors: Ruby Lieshout, Alessandra V. S. Faria, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Monique M. A. Verstegen and Gwenny M. Fuhler
    Citation: Molecular Medicine 2022 28:74
    Content type: Research article Published on:

  21. Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are devastating clinical disorders with high mortality, and for which more effective therapies are urgently needed. FGF1...

    Authors: Qhaweni Dhlamini, Wei Wang, Guifeng Feng, Aiping Chen, Lei Chong, Xue Li, Quan Li, Jin Wu, Depu Zhou, Jie Wang, Hailin Zhang and Jin-San Zhang
    Citation: Molecular Medicine 2022 28:73
    Content type: Research article Published on:

  22. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are clinical syndromes characterized by acute lung inflammation, pulmonary edema and hypoxemia, with up to 50% mortality rate without effective ...

    Authors: Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong and Ruowen Ge
    Citation: Molecular Medicine 2022 28:72
    Content type: Research article Published on:

  23. Complete healing of diabetic wounds continues to be a clinically unmet need. Although robust therapies such as stem cell therapy and growth factor treatment are clinically applied, these treatments are costly ...

    Authors: Peng-Hsiang Fang, Ying-Ying Lai, Chih-Ling Chen, Hsin-Yu Wang, Ya-Ning Chang, Yung-Chang Lin, Yu-Ting Yan, Cheng-Hung Lai and Bill Cheng
    Citation: Molecular Medicine 2022 28:71
    Content type: Research article Published on:

  24. 5-HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative dise...

    Authors: Alejandro Quintero-Villegas and Sergio Iván Valdés-Ferrer
    Citation: Molecular Medicine 2022 28:70
    Content type: Mini-review Published on:

  25. Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypophary...

    Authors: Mengyi Lao, Xiaozhen Zhang, Hanshen Yang, Xueli Bai and Tingbo Liang
    Citation: Molecular Medicine 2022 28:69
    Content type: Mini-review Published on:

  26. Thyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role in humans remains unknown.

    Authors: Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen and Vesa M. Olkkonen
    Citation: Molecular Medicine 2022 28:68
    Content type: Research article Published on:

  27. Approximately 25% of patients with early-stage breast cancer experience cancer progression throughout the disease course. Alterations in TMEM240 in breast cancer were identified and investigated to monitor treatm...

    Authors: Ruo-Kai Lin, Chih-Ming Su, Shih-Yun Lin, Le Thi Anh Thu, Phui-Ly Liew, Jian-Yu Chen, Huey-En Tzeng, Yun-Ru Liu, Tzu-Hao Chang, Cheng-Yang Lee and Chin-Sheng Hung
    Citation: Molecular Medicine 2022 28:67
    Content type: Research article Published on:

  28. At present, the molecular mechanisms underlying inflammation remain unclear. In recent years, research on inflammation has focused on stimulating cell inflammation by using exogenous pro-inflammatory substance...

    Authors: Wenxin Wang, Jie Geng, Xiaohan Wu, Jianguang Zhang, Chenna Zheng, Huachun Rao, Tianyu Li, Yong Diao and Huiyong Yang
    Citation: Molecular Medicine 2022 28:66
    Content type: Research article Published on:

  29. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that results from widespread immune complex deposition and secondary tissue injury. Hydroxychloroquine (HCQ) has been used clinically to trea...

    Authors: Jiali Ni, Haiyan Zhu, Li Lu, Zihe Zhao, Jiaxuan Jiang, Xiaokang You, Yuzhu Wang, Yuliang Ma, Zirui Yang, Yayi Hou and Huan Dou
    Citation: Molecular Medicine 2022 28:65
    Content type: Research article Published on:

  30. Hypoxia is one of the important characteristics of synovial microenvironment in rheumatoid arthritis (RA), and plays an important role in synovial hyperplasia. In terms of cell survival, fibroblast-like synovi...

    Authors: Ran Deng, Yan Wang, Yanhong Bu and Hong Wu
    Citation: Molecular Medicine 2022 28:64
    Content type: Research article Published on:

  31. Gastric cancer (GC) is one of the diseases that endanger human health with high morbidity and mortality. The positive rates of traditional biomarkers in the diagnosis of GC are low, so it is necessary to find ...

    Authors: Yu Zhang, Xinliang Gu, Xinyue Qin, Yuejiao Huang and Shaoqing Ju
    Citation: Molecular Medicine 2022 28:63
    Content type: Research article Published on:

  32. Ovarian cancer is one of the important factors that seriously threaten women's health and its morbidity and mortality ranks eighth among female cancers in the world. It is critical to identify potential and pr...

    Authors: Mengjun Zhang, Yuan Liu, Yue Yin, Zhenxing Sun, Yan Wang, Zexue Zhang, Fei Li and Xiuwei Chen
    Citation: Molecular Medicine 2022 28:62
    Content type: Research article Published on:

  33. Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis and death by asphyxiation. Other than post-exposure...

    Authors: James B. Machamer, Edwin J. Vazquez-Cintron, Sean W. O’Brien, Kyle E. Kelly, Amber C. Altvater, Kathleen T. Pagarigan, Parker B. Dubee, Celinia A. Ondeck and Patrick M. McNutt
    Citation: Molecular Medicine 2022 28:61
    Content type: Research article Published on:

  34. African Americans (AAs) are disproportionately affected by cardiovascular disease (CVD), they are 20% more likely to die from CVD than whites, chronic exposure to inflammation and oxidative stress contributes ...

    Authors: Dena Parsa, Luul A. Aden, Ashley Pitzer, Tan Ding, Chang Yu, Andre Diedrich, Ginger L. Milne, Annet Kirabo and Cyndya A. Shibao
    Citation: Molecular Medicine 2022 28:60
    Content type: Research article Published on:

  35. Cholinergic output, which could modulate innate immune responses through stimulation of α7 nicotinic acetylcholine receptor (α7nAChR), might be a target to minimize tissue damage in autoimmune disease. GTS-21,...

    Authors: Ziping Ye, Yunjuan Zhu, Nana Tang, Xiaojing Zhao, Jingyue Jiang, Jingjing Ma and Hongjie Zhang
    Citation: Molecular Medicine 2022 28:59
    Content type: Research article Published on:

  36. Glabridin (Glab) is a bioactive component of licorice that can ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom been reported. Herein, we explored the effect and underlying mechanism o...

    Authors: Hongtao Tan, Junxian Chen, Yicong Li, Yingshan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu and Yiqun Li
    Citation: Molecular Medicine 2022 28:58
    Content type: Research article Published on:

  37. Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histam...

    Authors: Huan Yang, Sam J. George, Dane A. Thompson, Harold A. Silverman, Téa Tsaava, Aisling Tynan, Valentin A. Pavlov, Eric H. Chang, Ulf Andersson, Michael Brines, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Molecular Medicine 2022 28:57
    Content type: Research article Published on:

  38. The dynamic balance of osteoblast and osteoclast is critical for bone homeostasis and overactive osteoclastic function may lead to osteoporosis. Activating transcription factor 1 (ATF1) is involved in osteocla...

    Authors: Lu-Lin Liu, Yao-Sheng Xiao, Wei-Min Huang, Sheng Liu, Li-Xing Huang, Jing-Hua Zhong, Peng Jia and Wu-Yang Liu
    Citation: Molecular Medicine 2022 28:56
    Content type: Research article Published on:

  39. The aim of this study was to draw a comprehensive mutational landscape of nasopharyngeal carcinoma (NPC) tumors and identify the prognostic factors for distant metastasis-free survival (DMFS).

    Authors: Zihan Zhou, Peifeng Li, Xianbin Zhang, Juan Xu, Jin Xu, Shui Yu, Dongqing Wang, Wei Dong, Xiujuan Cao, Hongjiang Yan, Mingping Sun, Xiuping Ding, Jun Xing, Peng Zhang, Limin Zhai, Tingyong Fan…
    Citation: Molecular Medicine 2022 28:55
    Content type: Research article Published on:

  40. Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition. Emerging evidence indicate that...

    Authors: Caroline Boulouis, Tobias Kammann, Angelica Cuapio, Tiphaine Parrot, Yu Gao, Elli Mouchtaridi, David Wullimann, Joshua Lange, Puran Chen, Mira Akber, Olga Rivera Ballesteros, Jagadeeswara Rao Muvva, C. I. Edvard Smith, Jan Vesterbacka, Oscar Kieri, Piotr Nowak…
    Citation: Molecular Medicine 2022 28:54
    Content type: Research article Published on:

  41. Authors: Chun Xi Liu, Qin Hu, Yan Wang, Wei Zhang, Zhi Yong Ma, Jin Bo Feng, Rong Wang, Xu Ping Wang, Bo Dong, Fei Gao, Ming Xiang Zhang and Yun Zhang
    Citation: Molecular Medicine 2022 28:53
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2010 17:Art10

  42. The altered gut microbiota is implicated in the pathogenesis of liver fibrosis. Resveratrol is a candidate for the treatment of liver fibrosis, which could ameliorate the dysregulation of gut microbiota in mic...

    Authors: Zhiqin Li, Jianxia Dong, Meng Wang, Jingya Yan, Yushu Hu, Yang Liu, Yajie Pan and Hua Li
    Citation: Molecular Medicine 2022 28:52
    Content type: Research article Published on:

  43. Thrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly...

    Authors: Bjoern F. Kraemer, Irina Hennis, Anne Karge, Anne Katrin Kraemer, Tobias F. Dreyer, Marion Kiechle, Bettina Kuschel and Holger Bronger
    Citation: Molecular Medicine 2022 28:51
    Content type: Research article Published on:

  44. The conversion of astrocytes activated by nerve injuries to oligodendrocytes is not only beneficial to axonal remyelination, but also helpful for reversal of glial scar. Recent studies have shown that patholog...

    Authors: Xinyu Liu, Conghui Li, Jiao Li, Lesi Xie, Zeng Hong, Kang Zheng, Xiaofeng Zhao, Aifen Yang, Xiaofeng Xu, Huaping Tao, Mengsheng Qiu and Junlin Yang
    Citation: Molecular Medicine 2022 28:50
    Content type: Research article Published on:

  45. The existence of breast cancer stem cells (BCSCs) causes tumor relapses, metastasis and resistance to conventional therapy in breast cancer. NDR1 kinase, a component of the Hippo pathway, plays important roles...

    Authors: Ling-Ling Wang, Xiao-Yun Wan, Chun-Qi Liu and Fei-Meng Zheng
    Citation: Molecular Medicine 2022 28:49
    Content type: Research article Published on:

  46. The appearance of alterations in normal metabolic activity has been increasingly considered a risk factor for the development of sporadic and late-onset neurodegenerative diseases. In this report, we induced c...

    Authors: Oriol Busquets, Triana Espinosa-Jiménez, Miren Ettcheto, Jordi Olloquequi, Mònica Bulló, Eva Carro, José Luis Cantero, Gemma Casadesús, Jaume Folch, Ester Verdaguer, Carme Auladell and Antoni Camins
    Citation: Molecular Medicine 2022 28:48
    Content type: Research article Published on:

  47. Receptor-interacting protein kinase 2 (RIPK2, also known as RIP2) was reported to be associated with bacterial infections as well as inflammatory responses. However, the role of RIPK2 in prognosis and immunoth...

    Authors: Junquan Song, Runyu Yang, Rongyuan Wei, Yue Du, Pengcheng He and Xiaowen Liu
    Citation: Molecular Medicine 2022 28:47
    Content type: Research article Published on:

  48. Risperidone, an atypical antipsychotic, impedes serotonin and dopamine receptor systems. Meanwhile, tumor necrosis factor-α (TNF-α) is known to participate in regulating osteoblast functions. Consequently, the...

    Authors: Shuyao Zhang, Wei He, Aiguo Li, Chengkuan Zhao, Yun Chen, Chengcheng Xu, Qiuzhen Zhang, Danling Zheng, Meini Chen, Haixiong Miao and Yihui Huang
    Citation: Molecular Medicine 2022 28:46
    Content type: Research article Published on:

  49. Clinical data suggest that male reproductive dysfunction especially infertility is a critical issue for type 1 diabetic patient (T1D) because most of them are at the reproductive age. Gut dysbiosis is involved...

    Authors: Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Ruqing Zhong, Xiangfang Tang, Wei Shen, Qingyuan Sun, Zhongyi Sun, Yonglin Ren, Hongfu Zhang and Yong Zhao
    Citation: Molecular Medicine 2022 28:45
    Content type: Research article Published on:

  50. Menopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety concerns with long-term treatment. We investigated the ability of 2′,3...

    Authors: Candice B. Herber, Chaoshen Yuan, Anthony Chang, Jen-Chywan Wang, Isaac Cohen and Dale C. Leitman
    Citation: Molecular Medicine 2022 28:44
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658