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Fig. 10 | Molecular Medicine

Fig. 10

From: An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality

Fig. 10

CNI-1493 protects against LPS-induced lethalitya

All animals received an L.D.50 dose of E. coli 0111:B4 LPS (13.75 mg/kg). Note that L-NMA significantly decreased survival, but CNI-1493 significantly improved survival. Each group consisted of 10 mice; differences between CNI-1493 and controls, and between L-NMA and controls, are statistically significant (p < 0.05 by the two-tailed Fisher’s exact test).

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