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Fig. 6 | Molecular Medicine

Fig. 6

From: An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality

Fig. 6

Pretreatment with CNI-1493 prevents cytokine-inducible NO production in quiescent RAW cellsa

In this preactivation experiment, there was a dose-dependent inhibition of nitrite production by addition of CNI-1493 at either 1 µM (open triangles) or 5 µM (closed triangles). Note that the inhibitory activity of CNI-1493 competes with increasing L-arginine concentration in the medium.

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