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Fig. 7 | Molecular Medicine

Fig. 7

From: An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality

Fig. 7

CNI-1493 does not inhibit EDRF activitya

Note that the normal response to increasing doses of the EDRF-dependent drug acetylcholine is an increasing blood pressure response (controls). In agreement with previously published work, pretreatment with L-NMA (positive controls) blunts EDRF activity. This stands in contrast to animals pretreated with CNI-1493, which manifest normal EDRF responses following acetylcholine challenge.

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