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Table 2 Identical or similar TCR VJ α sequences found in V α 2.3 + J α 9.11 + lung accumulated CD4 + BAL T cells recovered from two sarcoidosis Patients (Patients 1 and 2)

From: Restricted Usage of T Cell Receptor Vα/Jα Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis Patients

Sequence

Vα 2.3

 

9.11

 

C

V

V

 

D

Y

G

G

S

Q

G

N

2.3 + 2.14 + 1.10

5′-TGT

GTG

GTG

—

GAT

TAT

GGA

GGA

AGC

CAA

GGA

AAT

2.30

5′-TGT

GTG

GTG

—

GAT

TAC

GGA

GGA

AGC

CAA

GGA

AAT

2.43

5′-TGT

GTG

GTG

—

GAT

TAC

GGA

GGA

AGC

CAG

GGA

AAT

 

C

V

V

 

P

S

G

G

S

Q

G

N

2.8

5′-TGT

GTG

GTC

—

CCA

TCA

GGA

GGA

AGC

CAA

GGA

AAT

2.37

5′-TGT

GTG

GTC

—

CCA

TCA

GGA

GGG

AGC

CAA

GGA

AAT

  1. Nucleotides that alter between sequences are underlined. The identical sequences 2.3/2.14 and 1.10 are from two different patients (Patients 2 and 1, respectively). Note that the tyrosine (Y) at the second 5′ position of Jα 9.11, in the upper group of sequences, is substituted with a serine (S), with similar properties, in sequences 2.8 and 2.37.
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Molecular Medicine

ISSN: 1528-3658