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Table 2 Identical or similar TCR VJ α sequences found in V α 2.3 + J α 9.11 + lung accumulated CD4 + BAL T cells recovered from two sarcoidosis Patients (Patients 1 and 2)

From: Restricted Usage of T Cell Receptor Vα/Jα Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis Patients

Sequence Vα 2.3   9.11
  C V V   D Y G G S Q G N
2.3 + 2.14 + 1.10 5′-TGT GTG GTG — GAT TAT GGA GGA AGC CAA GGA AAT
2.30 5′-TGT GTG GTG — GAT TAC GGA GGA AGC CAA GGA AAT
2.43 5′-TGT GTG GTG — GAT TAC GGA GGA AGC CAG GGA AAT
  C V V   P S G G S Q G N
2.8 5′-TGT GTG GTC — CCA TCA GGA GGA AGC CAA GGA AAT
2.37 5′-TGT GTG GTC — CCA TCA GGA GGG AGC CAA GGA AAT
  1. Nucleotides that alter between sequences are underlined. The identical sequences 2.3/2.14 and 1.10 are from two different patients (Patients 2 and 1, respectively). Note that the tyrosine (Y) at the second 5′ position of Jα 9.11, in the upper group of sequences, is substituted with a serine (S), with similar properties, in sequences 2.8 and 2.37.
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Molecular Medicine

ISSN: 1528-3658