Fig. 3

Immunohistochemical staining of endothelial vascular adhesion molecule-1 (VCAM-1) (a–d), and intercellular adhesion molecule-1 (ICAM-1) expression in aortic sections of euglycemic rabbits treated with AGE-modified rabbit serum albumin (AGE-RSA) or saline with varying diet

Treatments for rabbits were as follows: (a,e) AGE-RSA, 16 mg/kg/d i.v. × 4 months; (b,f) normal saline, 0.5 ml × 4 months; (c,g) AGE-RSA, 16 mg/Kg/d i.v. × 4 months, plus cholesterol-rich diet (CRD) × 2 weeks (AGE + CRD); (d,h) CRD alone X 2 weeks. Arrowheads indicate areas of respective endothelial adhesion molecule expression.