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Table 3 Demonstration that only a few amino acid sidechains present in natural sequences are necessary for high-affinity binding to I-A u

From: Quantitative Analysis of Peptides from Myelin Basic Protein Binding to the MHC Class II Protein, I-Au, Which Confers Susceptibility to Experimental Allergic Encephalomyelitis

  

I-A u IC 50 (nM)

MBP Ac 1–11 Y4

AcASQYRPSQRHG

100

 

AAAAYRAAAAAAA

31

Ovalbumin 323–339

ISQAVHAAHAEINEAGR

25

 

AAVHAAHAAAAAA

4

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Molecular Medicine

ISSN: 1528-3658