Restoration of an antigen-induced immunoglobulin class switch upon bone marrow transplantation into TNF-LTα-deficient mice
The reconstituted mice were immunized with SRBC (2 × 108 i.p.) and the SRBC-specific IgM (A), IgG1 (B), IgG2b (C), and IgG3 (D) titers were determined by ELISA at 6 (shaded bar) and 15 days (open bar) after immunization. Preimmunization sera (black bars) are shown as baseline. Results are pooled from two independent experiments and expressed as mean ± SEM (n = 7–8 mice/group).