Fig. 5
From: Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury
Local overexpression of CSF-1 causes initial Mϕ accumulation, followed by lymphocytes infiltration in the MRL- lpr kidney
Three days post-Ix, the cells accumulated in the capsule are predominantly Mϕ (F4/80) (A), with only a few lymphocytes (B). By comparison, 28 days post-Ix, only a few Mϕ were identified in the intrarenal lesion (C, arrow) in which many B220-positive cells accumulated (D). sc, subcapsular space. (Magnification: A–D, 330×.)