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Table 3 Lod scores for markers at or near the COL1A1, COL1A2, and VDR loci

From: Osteopenia in 37 Members of Seven Families: Analysis Based on a Model of Dominant Inheritance

Marker/Family Lod score at θ =
0.0 0.01 0.05 0.1 0.2 0.3
D17S798       
1 −0.97 −0.91 −0.69 −0.48 −0.20 −0.07
2 −0.29 −0.29 −0.29 −0.25 −0.13 −0.05
3 Not determined     
4 −0.72 −0.66 −0.47 −0.30 −0.10 −0.03
5 −0.62 −0.56 −0.39 −0.26 −0.12 −0.05
6 −1.05 −1.00 −0.81 −0.61 −0.30 −0.12
7 −0.25 −0.23 −0.15 −0.07 0.02 0.03
Total −3.90 −3.65 −2.80 −1.96 −0.84 −0.29
HOX2B       
1 −0.91 −0.88 −0.75 −0.59 −0.34 −0.15
2 0.17 0.22 0.35 0.43 0.42 0.28
3 −2.01 −1.85 −1.39 −1.02 −0.55 −0.26
4 −0.02 0.00 0.07 0.10 0.10 0.05
5 −0.70 −0.64 −0.45 −0.31 −0.14 −0.07
6 −0.48 −0.44 −0.34 −0.25 −0.14 −0.07
7 −0.34 −0.31 −0.16 0.01 0.17 0.16
Total −4.28 −3.89 −2.67 −1.63 −0.48 −0.05
D17S806       
1 −1.50 −1.38 −1.07 −0.80 −0.42 −0.18
2 −0.67 −0.63 −0.47 −0.30 −0.09 −0.02
3 Not determined     
4 −1.12 −1.01 −0.69 −0.41 −0.12 −0.03
5 −0.02 −0.02 −0.02 −0.01 −0.01 −0.00
6 0.13 0.18 0.28 0.31 0.26 0.14
7 0.12 0.11 0.08 0.06 0.06 0.07
Total −3.06 −2.76 −1.89 −1.15 −0.32 −0.01
Intron 1 COL1A2       
1 −0.38 −0.36 −0.29 −0.21 −0.08 −0.01
2 −0.49 −0.47 −0.39 −0.29 −0.16 −0.07
3 −0.01 −0.01 −0.01 −0.01 −0.01 −0.00
4 −0.89 −0.84 −0.69 −0.52 −0.27 −0.10
5 −0.57 −0.51 −0.35 −0.24 −0.11 −0.04
6 −0.99 −0.91 −0.68 −0.47 −0.23 −0.09
7 −0.66 −0.64 −0.58 −0.49 −0.28 −0.12
Total −3.99 −3.76 −2.99 −2.24 −1.13 −0.44
Intron 12 COL1A2       
1 −0.21 −0.21 −0.18 −0.15 −0.09 −0.04
2 0.01 0.01 0.02 0.02 0.03 0.04
3 0.85 0.83 0.75 0.65 0.46 0.28
4 −0.88 −0.84 −0.68 −0.53 −0.28 −0.12
5 −0.61 −0.55 −0.39 −0.26 −0.12 −0.05
6 −0.87 −0.80 −0.59 −0.42 −0.21 −0.08
7 −1.55 −1.54 −1.45 −1.19 −0.63 −0.25
Total −3.26 −3.09 −2.52 −1.86 −0.83 −0.24
D7S558       
1 Not determined     
2 0.18 0.19 0.19 0.19 0.14 0.07
3 0.23 0.23 0.21 0.19 0.19 0.14
4 −1.17 −1.10 −0.88 −0.66 −0.35 −0.15
5 Not determined     
6 Not determined     
7 Not determined     
Total −0.76 −0.69 −0.47 −0.28 −0.08 −0.01
COL2A1       
1 −0.15 −0.14 −0.09 −0.05 −0.00 −0.03
2 −0.45 −0.44 −0.41 −0.34 −0.20 −0.08
3 −1.35 −1.28 −1.05 −0.81 −0.46 −0.24
4 Not determined     
5 −0.73 −0.68 −0.50 −0.35 −0.17 −0.07
6 0.79 0.78 0.72 0.63 0.43 0.22
7 −1.52 −1.47 −1.22 −0.92 −0.49 −0.22
Total −3.40 −3.23 −2.54 −1.83 −0.88 −0.36