Osteopenia in 37 Members of Seven Families: Analysis Based on a Model of Dominant Inheritance

Spotila, Loretta D.; Caminis, John; Devoto, Marcella; Shimoya, Koichiro; Sereda, Larisa; Ott, Jürg; Whyte, Michael P.; Tenenhouse, Alan; Prockop, Darwin J.

doi:10.1007/BF03401629

Molecular Medicine

Table 3 Lod scores for markers at or near the COL1A1, COL1A2, and VDR loci

From: Osteopenia in 37 Members of Seven Families: Analysis Based on a Model of Dominant Inheritance

Marker/Family	Lod score at θ =
Marker/Family	0.0	0.01	0.05	0.1	0.2	0.3
D17S798
1	−0.97	−0.91	−0.69	−0.48	−0.20	−0.07
2	−0.29	−0.29	−0.29	−0.25	−0.13	−0.05
3	Not determined
4	−0.72	−0.66	−0.47	−0.30	−0.10	−0.03
5	−0.62	−0.56	−0.39	−0.26	−0.12	−0.05
6	−1.05	−1.00	−0.81	−0.61	−0.30	−0.12
7	−0.25	−0.23	−0.15	−0.07	0.02	0.03
Total	−3.90	−3.65	−2.80	−1.96	−0.84	−0.29
HOX2B
1	−0.91	−0.88	−0.75	−0.59	−0.34	−0.15
2	0.17	0.22	0.35	0.43	0.42	0.28
3	−2.01	−1.85	−1.39	−1.02	−0.55	−0.26
4	−0.02	0.00	0.07	0.10	0.10	0.05
5	−0.70	−0.64	−0.45	−0.31	−0.14	−0.07
6	−0.48	−0.44	−0.34	−0.25	−0.14	−0.07
7	−0.34	−0.31	−0.16	0.01	0.17	0.16
Total	−4.28	−3.89	−2.67	−1.63	−0.48	−0.05
D17S806
1	−1.50	−1.38	−1.07	−0.80	−0.42	−0.18
2	−0.67	−0.63	−0.47	−0.30	−0.09	−0.02
3	Not determined
4	−1.12	−1.01	−0.69	−0.41	−0.12	−0.03
5	−0.02	−0.02	−0.02	−0.01	−0.01	−0.00
6	0.13	0.18	0.28	0.31	0.26	0.14
7	0.12	0.11	0.08	0.06	0.06	0.07
Total	−3.06	−2.76	−1.89	−1.15	−0.32	−0.01
Intron 1 COL1A2
1	−0.38	−0.36	−0.29	−0.21	−0.08	−0.01
2	−0.49	−0.47	−0.39	−0.29	−0.16	−0.07
3	−0.01	−0.01	−0.01	−0.01	−0.01	−0.00
4	−0.89	−0.84	−0.69	−0.52	−0.27	−0.10
5	−0.57	−0.51	−0.35	−0.24	−0.11	−0.04
6	−0.99	−0.91	−0.68	−0.47	−0.23	−0.09
7	−0.66	−0.64	−0.58	−0.49	−0.28	−0.12
Total	−3.99	−3.76	−2.99	−2.24	−1.13	−0.44
Intron 12 COL1A2
1	−0.21	−0.21	−0.18	−0.15	−0.09	−0.04
2	0.01	0.01	0.02	0.02	0.03	0.04
3	0.85	0.83	0.75	0.65	0.46	0.28
4	−0.88	−0.84	−0.68	−0.53	−0.28	−0.12
5	−0.61	−0.55	−0.39	−0.26	−0.12	−0.05
6	−0.87	−0.80	−0.59	−0.42	−0.21	−0.08
7	−1.55	−1.54	−1.45	−1.19	−0.63	−0.25
Total	−3.26	−3.09	−2.52	−1.86	−0.83	−0.24
D7S558
1	Not determined
2	0.18	0.19	0.19	0.19	0.14	0.07
3	0.23	0.23	0.21	0.19	0.19	0.14
4	−1.17	−1.10	−0.88	−0.66	−0.35	−0.15
5	Not determined
6	Not determined
7	Not determined
Total	−0.76	−0.69	−0.47	−0.28	−0.08	−0.01
COL2A1
1	−0.15	−0.14	−0.09	−0.05	−0.00	−0.03
2	−0.45	−0.44	−0.41	−0.34	−0.20	−0.08
3	−1.35	−1.28	−1.05	−0.81	−0.46	−0.24
4	Not determined
5	−0.73	−0.68	−0.50	−0.35	−0.17	−0.07
6	0.79	0.78	0.72	0.63	0.43	0.22
7	−1.52	−1.47	−1.22	−0.92	−0.49	−0.22
Total	−3.40	−3.23	−2.54	−1.83	−0.88	−0.36

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ISSN: 1528-3658

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