Oxidative and nonoxidative glucose disposal and glycogen synthesis rates in normal and IDDM subjects
The oxidative and nonoxidative glucose disposal rates were determined from glucose clamp requirements and indirect calorimetry. The whole body rate of glycogen synthesis was calculated by adding the 13C NMR rate measured in the gastrocnemius muscle over the total body muscle mass. In both groups, total nonoxidative glucose disposal is accounted for by total muscle glycogen synthesis, but in the NIDDM group this rate is about one-half of that in the control group. Adapted from Shulman et al., N. Engl. J. Med. 322: 223–228. Copyright 1990. Massachusetts Medical Society. All rights reserved.