Fig. 1
From: Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy
Establishment of transgenic mouse lines with cardiac-specific expression of a mutant Myh
Transgenic mice were produced in a CBA/B16 (Fl cross) background and identified using standard techniques. The transgene consists of a mutant rat α Myh cDNA flanked by heterologous introns at the 5′ and 3′ end, and promoter elements provided by approximately 3.3 kb of rat α Myh 5′-flanking DNA (27). Five independent transgenic lines number were identified: Lines 131, 136, 138, 140, and 143.