Fig. 4
From: Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy
The foci of hypertrophy and cellular disarray contain myocytes with degenerating myofibrils
Hearts from 5 month old 140 line transgenic mice were embedded in plastic resin and abnormal regions within the left ventricle were identified in thick sections of plastic embedded tissue. Thin sections were cut from these regions, stained with uranyl acetate and lead citrate and examined on the electron microscope. Myofibrillar disarray as well as degeneration were evident. Most striking was the observation that severely effected myocytes often bordered on apparently normal cells with the frequent loss of myofibrils bordering the intercalated disc. Bar = 20 µm.