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Fig. 4 | Molecular Medicine

Fig. 4

From: Characterization and Cell Distribution of Polycystin, the Product of Autosomal Dominant Polycystic Kidney Disease Gene 1

Fig. 4

Immunolocalization of polycystin in kidneys from two patients with ADPKD

AP1 (a, b, c, e, and f) and AP-2 (d) were used for immunostaining. (a–d) There is intense cytoplasmic staining of the epithelial cells of cystic tubules (arrows) in Patient 1 (a) and 2 (b and c). Staining was largely abolished in the presence of P1 (c). Bar = 20 µm. (e and f) Confocal microscopy images of tissue sections from normal human fetal kidney (e) and ADPKD kidney from Patient 2 (f) are shown. The strong apical (arrows) and weak basal (arrow heads) staining in normal epithelium is replaced by heavy cytoplasmic staining in the cyst-lining epithelial cells (d, arrows), that is most intense in the preinuclear region. Bar = 20 µm.

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Molecular Medicine

ISSN: 1528-3658