Skip to main content
Fig. 2 | Molecular Medicine

Fig. 2

From: A Major Allergen of Lymphatic Filarial Nematodes Is a Parasite Homolog of the γ-Glutamyl Transpeptidase

Fig. 2

Comparison of the B. malayi γ -GT homolog and human γ-GT-deduced amino acid sequences

The amino acid sequence from the cDNA of B. malayi was aligned to that of human γ-GT (26). The H and L subunits are boxed. Gaps (indicated by dashes) have been introduced to maximize best pairing of homologous amino acids; numbers indicate the amino acid residue in the ORF. Identical residues are indicated by bars (

); conservative substitutions by two points (:). The shaded box indicates the position of the two crucial Asp residues located in the active site of the enzyme. Shared or unique cysteine residues are boxed. The asterisk (*) indicates the position of Thr-555 corresponding to human Thr-524 involved in the binding of acivicin.

Back to article page

Molecular Medicine

ISSN: 1528-3658