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Fig. 2 | Molecular Medicine

Fig. 2

From: The βc Component of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)/Interleukin 3 (IL-3)/IL-5 Receptor Interacts with a Hybrid GM-CSF/Erythropoietin Receptor to Influence Proliferation and β-Globin mRNA Expression

Fig. 2

β c confers a high-affinity hGM-CSF proliferative response on GMER, whereas β tr acts as a dominant negative

Tritiated thymidine incorporation assay of Ba/F3-GMER (□), Ba/F3-GMER + βc (●), and Ba/F3-GMER + βtr (■). The upper panel shows that Ba/F3-GMER + βc have the same maximum proliferation as Ba/F3-GMER but a 3-log increase in hGM-CSF sensitivity. Ba/F3-GMER + βtr proliferation is markedly inhibited; the upper plot is replotted with an expanded γ-axis in the lower panel to show that the half-maximal proliferative response is similar to Ba/F3-GMER. The data are from one of three experiments.

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Molecular Medicine

ISSN: 1528-3658