Fig. 1

Schematic of β PP showing antibody epitopes

The black box represents Aβ with the amino acid sequence shown below. The vertical dashed boxes and horizontal stippled box represent the plasma membrane and the Kunitz protease inhibitor (KPI) domain, respectively, “α” and “β” indicate α- and β-secretase cleavage sites. Horizontal black bars represent the approximate epitopes of antibodies B5, 5A3, 1G7, CT15, 1736, and 1282.