Fig. 3
From: A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein
Amino acid sequence alignment of MDM2 1–115
The mutations identified from the yeast screen are indicated with large arrows and mutations affecting p53 interaction identified by site-directed mutagenesis are shown with small arrows. Stars indicate residues that are 100% conserved between species, and dots indicate that the amino acids are of similar character.