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Table 1 Limb and Kidney Phenotypes of F1 Compound Heterozygotes from Homozygous Crosses

From: The Role of a Single Formin Isoform in the Limb and Renal Phenotypes of Limb Deformity

   

Normal kidneys

Abnormal (%)

Kidney abnormality

Genotype

Normal limbs

0

1

2

ldGKO/ +

92/92

0

0

92

0

None

ldGKO/ldGKO

105/105

1

5

99

6%*

Agenesis

ldGKO/ldTgBri

62/62

0

1

61

2%

Agenesis

ldGKO/ldln2

43/43

1

0

42

2%

Multicystic dysplastic

  1. Matings were between homozygous parents to give uniform genotypes in each litter. Pregnant females were checked twice daily for litters to minimize the chance of missing pups that died at birth. All pups were scored for limb phenotype and for the number of kidneys by inspection under a dissecting microscope.
  2. *p < 0.05, when compared with ldGKO/+ neonates by Fisher’s exact test.
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Molecular Medicine

ISSN: 1528-3658