Fig. 2
From: Cystic Fibrosis of the Pancreas: Involvement of MUC6 Mucin in Obstruction of Pancreatic Ducts
Expression of MUC6 and CFTR mRNA in 23-week pancreas and in 28+3 week CF pancreas
(A–F) Expression of MUC6 mRNA (A–C) and CFTR (D–F) in 23-week fetal pancreas. Panels A and D show bright-field views of pancreas sections hybridized with the MUC6 and CFTR antisense probes, respectively, and panels B and E show dark-field images of the same sections. Panels C and F show dark-field views of consecutive sections hybridized with the MUC6 and CFTR sense negative control probes, respectively. Panels G-L show expression of MUC6 mRNA (G–I) and CFTR (J–L) in 28 + 3 week CF fetal pancreas. Panels G and J show bright-field views of pancreas sections hybridized with the MUC6 and CFTR anti-sense probes, respectively, and panels H and K show dark-field images of the same sections. Panels I and L show dark-field views of consecutive sections hybridized with the MUC6 and CFTR sense negative control probes, respectively. Arrowheads in panels A, D, G and J and arrows in panels B, E, H and K denote interlobular ducts, intralobular ducts and developing acini. Scale bar = 200 µm for all panels.