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Fig. 4 | Molecular Medicine

Fig. 4

From: Differential Regulation of the p21/WAF-1 and mdm2 Genes after High-Dose UV Irradiation: p53-Dependent and p53-Independent Regulation of the mdm2 Gene

Fig. 4

The initial decrease of Mdm2 expression after high-dose UV irradiation is p53-inde-pendent

The MEF from p53 knockout mice (MEFKO p53-/-), H1299 cells and Saos-2 cells, all of which lack the endogenous expression of p53, were treated with a dose of 20 J/M2 UV and harvested at the indicated times. The protein levels of Mdm2 were analyzed by IP-Western (A) and the mRNA levels of mdm2 were examined by Northern analysis (B) as described in Figures 1 and 3.

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Molecular Medicine

ISSN: 1528-3658