Fig. 3From: Molecular and Structural Characterization of Five Novel Mutations in the Bruton’s Tyrosine Kinase Gene from Patients with X-Linked Agammaglobulinemia Altered splicing of the Btk transcript in P11 and P12 Exons 17, 18, and 19 are shown as rectangles. Introns are shown as lines (not in scale). The donor splice-site mutation, G to T, in intron 18 (+1) is predicted to cause splicing of exon 17 with exon 19, skipping exon 18 altogether.Back to article page