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Fig. 8 | Molecular Medicine

Fig. 8

From: Chondroitin-4-Sulfate Impairs In Vitro and In Vivo Cytoadherence of Plasmodium falciparum Infected Erythrocytes

Fig. 8

CSA-dependence of the IRBC release

IRBCs in the blood samples collected just before and 8 hr after the injection of CSA in Animals 89085 (□ and , respectively) and 8901M ( and ■, respectively) were tested on 1D cells for their cytoadherence phenotypes. The cytoadherence assay was performed in the presence of 100 µg/ml of CSA, 10 µg/ml of anti-CD36 monoclonal FA6-152 antibody, or 25 µg/ml of anti-ICAM-1 monoclonal 84H10 antibody and the inhibition is expressed as the percentage of a control performed in the absence of CSA or in the presence of unrelated mouse IgG1 antibody (777 ± 170 cytoadherent IRBC/mm2 and 316 ± 176 for the blood samples collected before injections and 400 ±151 and 488 ± 250 for the blood sample collected 8 hr after injection for Monkeys 89085 and 8901M, respectively).

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