Fig. 5

Adoptive transfer of tissue infiltrating T cells with a survival advantage in xenografts

Temporal artery tissue was engrafted as described in Fig. 1. After 4 weeks, a T cell line was established from explanted tissue. T cells from this line were adoptively transferred into mice carrying implants of temporal artery tissue from the same patient. Control mice received T cells isolated from a peripheral blood lymphocyte line of the tissue donor. Tissue implants were retrieved 5 days after the adoptive transfers and in situ transcription of lymphokines was determined. Results are expressed as the percent increase of in situ cytokine production in the chimeras that had received tissue-derived T cells compared with that in the control mice.