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Table 2 Synapse formation in wild-type, synapsin I, synapsin n, and synapsin I/II double knockout (k.o.) mice

From: Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

 

Number of synapses/cell

Days in culture

Wild-type

Synapsin I a k.o.

Synapsin II k.o.

Synapsins I/II k.o.

4

18.4 ± 2

0**

0**

0**

7

40.8 ± 3.9

0.5 ± 0.2**

29.9 ± 4.6*

31.1 ± 2.62*

10

64.2 ± 3.9

37.5 ± 4.9**

57.6 ± 2.58*

63.8 ± 5.8

14

75.5 ± 6.5

70.6 ± 6.0

73.2 ± 4.8

77.5 ± 6.2

  1. Embryonic E16 hippocampal neurons were grown in culture for up to 14 days. Twenty fields were analyzed for each time point and experimental condition from three different experiments. Values are given as number of synapses/cell. Each number represents the mean ± SEM. Differs from wild type: *P < 0.05 and **P < 0.001.
  2. aData from Chin et al., 1995 (11).
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Molecular Medicine

ISSN: 1528-3658