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Fig. 2 | Molecular Medicine

Fig. 2

From: Susceptibility Locus for IgA Deficiency and Common Variable Immunodeficiency in the HLA-DR3, -B8, -A1 Haplotypes

Fig. 2

DNA marker analysis of selected loci across class I, II, and III regions. (A) Map of the MHC locus on chromosome six showing the relative position of selected class I, II, and III genes as well as the approximate location of 11 markers used to identify haplotype 1. A susceptibility locus for IgAD/CVID appears to lie within the interval illustrated by the open bar, which is delimited by microsatellite markers 821/823 towards the class II terminus and HLA-B at the class I terminus of the region. (B) An expanded view of the susceptibility locus illustrated in the open bar above and the genes that have been mapped to this interval (24).

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Molecular Medicine

ISSN: 1528-3658