Soft Tissue Sarcomas and p53 Mutations

Table 1 Frequency of p53 mutations in different STS reported through 1997

Entity	Patients	Tumors	Total	With p53 Mutation	Frequency in %
Synovial sarcoma	7	8	15	0	0
Neuroblastoma	77	53	130	5	3.9
Fibrosarcoma	29	12	41	2	4.9
MFH	80	143	223	26	11.7
MPNST	30	34	64	8	12.5
Liposarcoma	67	54	121	21	17.4
Mesothelioma	17	4	21	4	19.1
Leiomyosarcoma	46	75	121	23	19.0
Rhabdomyosarcoma	49	17	66	16	24.2
PNET (without Nb)		20	20	8	40.0
Angiosarcoma	6		6	3	50.0
Mixed-mesenchymal tumors		41	41	24	58.5
Undifferentiated sarcoma	1		1	1
Total	409	461	870	142	16.3

MFH, malignant fibrous histiocytoma; MPNST, malignant peripheral nerve sheath tumor; PNET, primitive neuroectodermal tumor; Nb, neuroblastoma. Compilation is based on data of a p53 mutational bank (25) and on further results (26–28).

ISSN: 1528-3658