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Fig. 1 | Molecular Medicine

Fig. 1

From: Specific Killing of HIV-infected Lymphocytes by a Recombinant Immunotoxin Directed against the HIV-1 Envelope Glycoprotein

Fig. 1

Plasmid for expression of 3B3(Fv)-PE38 immunotoxin. (A) Schematic of 3B3(Fv)-PE38. The VH and VL portion of antibody 3B3 linked by a 15 amino acid linker and fused to the translocation and ADP ribosylation domains of PE. (B) The expression plasmid pTKB22.18 encodes the VH and VL domains of antibody 3B3 fused in frame to PE38. The carboxy terminus of VL is linked to the amino terminus of the toxin molecule (PE38).

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Molecular Medicine

ISSN: 1528-3658