Fig. 1

Anti-MIF Ab treatment improves renal function in rat anti-GBM disease. The effect of anti-MIF Ab (open circles, dotted line) and irrelevant control Ab treatment (closed circles, solid line) was assessed in terms of (a) urinary protein excretion, (b) serum urea levels, (c) serum creatinine levels, and (d) the rate of creatinine clearance. Data are shown as the mean ± SEM for six animals. *p < 0.05, **p < 0.01, ***p < 0.001 versus time-matched control Ab-treated animals; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus day 7 by ANOVA. The group of six animals killed on day 7 of disease without any treatment had 291 ± 42 mg protein/24 hr, 17.3 ± 3.5 nmol urea/L, 63 ± 6.8 µmol creatinine/L, and 0.48 ± 0.03 ml/min creatinine clearance.