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Fig. 7 | Molecular Medicine

Fig. 7

From: Reversal of Established Rat Crescentic Glomerulonephritis by Blockade of Macrophage Migration Inhibitory Factor (MIF): Potential Role of MIF in Regulating Glucocorticoid Production

Fig. 7

Anti-MIF Ab treatment suppresses renal IL-1β production in rat anti-GBM disease. Immunohistochemistry staining of IL-1β protein was assessed in (a) glomeruli and (b) cortical tubules. Data arc shown as the mean ± SEM for six animals killed on day 7 of disease without treatment (open bars), and after treatment with an irrelevant control Ab (closed bars) or an anti-MIF Ab (hatched bars) over days 7 to 21. *p < 0.05, **p < 0.01, ***p < 0.001, and NS, not significant by ANOVA. Values for normal rats are 0.8 ± 0.1 glomerular IL-1β+ score (p < 0.001 versus day 7 untreated) and 53 ± 7% IL-1β+ tubules (p = N.S. versus day 7 untreated).

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Molecular Medicine

ISSN: 1528-3658