Reversal of Established Rat Crescentic Glomerulonephritis by Blockade of Macrophage Migration Inhibitory Factor (MIF): Potential Role of MIF in Regulating Glucocorticoid Production

Table 1 Serum corticosterone levels correlate with disease parameters in rat anti-GBM disease

Disease Parameter Measured on Day 21 ^a	Day 21 Serum Corticosterone Level ^a
Glomerular MIF mRNA⁺ cells	r = −0.77, p = 0.005
Tubular MIF mRNA⁺ cells	r= −0.87, p< 0.001
Glomerular ED1⁺ macrophage	r = −0.57, p = N.S.
Interstitial ED1⁺ macrophages	r= −0.57, p < 0.001
Interstitial IL-2R⁺ cells	r = −0.82, p = 0.002
Proteinuria	r = −0.61, p = 0.046
Serum creatinine	r = −0.82, p = 0.002
Creatinine clearance	r = 0.72, p = 0.013
Serum urea	r = −0.72, p = 0.013

^a Data are pooled from both control and anti-MIF Ab-treated animals on day 21 (n = 12) and analyzed using the Pearson single correlation coefficient.

ISSN: 1528-3658