Fig. 3
From: β-Cell Apoptosis in an Accelerated Model of Autoimmune Diabetes
Confocal microscopy of islets from B7-1 NOD.scid mice showing different degrees of β-cell destruction, 10 days after transfer of splenocytes from diabetic NOD mice. B7-1 is labeled green and TUNEL-positive nuclei are labeled red. (A) Uniform, strong B7-1 staining with no evidence of β-cell loss or TUNEL-positive nuclei. (B) Nonuniform B7-1 staining of cells also positive for TUNEL, in an islet with patchy β-cell loss. (C) Absent B7-1 staining in an islet positive for TUNEL.