Table 1 Apoptotic events (mean ± SD) and insulitis scores (mean ± SD) in B7-1 transgenic and control NOD. scid mice after transfer of splenocytes from diabetic NOD mice
From: β-Cell Apoptosis in an Accelerated Model of Autoimmune Diabetes
Days after Transfer of IDDM | Control NOD. scid Mice | B7-1 Transgenic NOD. scid Mice | ||
|---|---|---|---|---|
Apoptotic Events/104 µm2 (n islets) | Insulitis Score (n mice) | Apoptotic Events/104 µm2 (n islets) | Insulitis Score (n mice) | |
5 | 0.100 ± 0.267 (n = 85) | 0.663 ± 0.050 (n = 4) | 0.035 ± 0.169 (n = 70) | 0.736 ± 0.191 (n = 4) |
10 | 0.074 ± 0.160 (n = 74) | 1.027 ± 0.694 (n = 8) | 0.867 ± 1.036 (n = 75)**,## | 2.194 ± 0.643 (n = 8)++ |
15 | 0.304 ± 0.523 (n = 51) | 1.500 ± 0.551 (n = 3) | 1.115 ± 2.526 (n = 66)*# | 3.044 ± 1.180 (n = 3)+ |