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Table 1 Levels of L -Arg and L -Cit

From: High Concentration of L-Arginine Suppresses Nitric Oxide Synthase Activity and Produces Reactive Oxygen Species in NB9 Human Neuroblastoma Cells

  

Intracellular

 
  

L-Arg

L-Cit

 

Cells

Medium

(pmol/10 6 cells)

NOS Activity (%)

NB9

50 µM L-Arg

68.0 ± 1.0

N.D.

100

 

2 mM L-Arg

1310.0 ± 5.0*

47.1 ± 0.2

71.0 ± 4.8**

IMR32

50 µM L-Arg

88.4 ±2.1

N.D.

129.0 ± 14.5

 

2 mM L-Arg

1467.2 ± 10.0*

51.2 ± 0.5

72.6 ± 9.7**

  1. Cells were treated with 50 µM or 2 mM L-Arg for 48 hr.
  2. Values are expressed as mean ± SD of three independent analyses.
  3. *p < 0.001, **p < 0.005, significantly different from 50 µM L-Arg.
  4. N.D., not detectable.
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Molecular Medicine

ISSN: 1528-3658