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Table 2 Effect of L -Cit on NOS activity

From: High Concentration of L-Arginine Suppresses Nitric Oxide Synthase Activity and Produces Reactive Oxygen Species in NB9 Human Neuroblastoma Cells

  

Intracellular

Cells

Medium

L-Cit (pmol/106 cells)

NOS activity (%)

NB9

L-Cit 0/µM

N.D.

100

 

50 µM

25.0 ± 1.0

63.3 ± 1.1*

 

100 µM

82.1 ± 1.5

56.7 ±1.2*

 

250 µM

97.0 ± 0.9

37.2 ±0.8*

 

500 µM

108.1 ± 1.0

35.2 ± 1.3*

  1. Cells were treated with various concentrations of L-Cit in the presence of 50 µM L-Arg for 48 hr.
  2. Values are mean ± SD of three independent analyses.
  3. *p < 0.005, significantly different from 0/µM L-Cit.
  4. N.D., not detectable.
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Molecular Medicine

ISSN: 1528-3658