Table 2 Possible variants of known germline V λ gene segments expressed in cDNA clones from patients with rheumatoid arthritis and normal controls
Gene Segment | Codon | Domain | Reported Sequence | Variant Sequence | Non-clonally Related Sequences Containing Described Variation | % of clones with variant sequence |
|---|---|---|---|---|---|---|
IGLV3S2 | 92 | CDR3 | GAC | GAT | ASSynL182, 232; ASPBLL1, 220, 234; BCPBLL11; BCSynL4, 21, 22, 24 | 83.3% |
hsigll150 | 32 | CDR1 | TAT | TTT | ASSynL202, 209; ASPBLL42, 53; BCSynL47; ITPBLL70 | 14.3% |
hsigll150 | 33 | CDR1 | GCT | GTT | ASSynL216; ASPBLL42, 53; BCSynL51; LBPBLL3F; LKPBLL9; ITPBLL11, 70 | 17.8% |
hsigll150 | 46 | FR2 | CTG | TTG | ASSynL204, 215, 216; ASPBLL48, 51, 59; BCSynL47; BCPBLL27; LBPBLL2, 3F, 5; LKPBLL9, 59; ITPBLL 13, 45, 70, 80 | 40.0% |
hsigll150 | 52 | CDR2 | AGT | ACT | ASSynL209, 210, 211, 215, 216; ASPBLL42 53; LBPBLL2; LKPBLL59, 76, 72; ITPBLL70, 76 | 28.9% |
hsigll150 | 87 | FR3 | TAC | TAT | ASSynL84, 202, 209, 211, 214, 216; ASPBLL42, 53; BCSynL17, 51; BCPBLL27; LBPBLL3J, 3K, 3S, 5; ITPBLL45 | 35.6% |
III.1 | 20 | FR1 | AGC | ACC | ASPBLL2, 12, 13; BCPBLL8; LBPBLL4H; LKPBLL25 | 18.8% |
III.1 | 52 | CDR2 | AGC | AAC | BCSynL56; BCPBLL6, 7, 9; ASPBLL10; LBPBLL4H; LKPBLL84, 85, 87, 88; ITPBLL25, 97 | 39.4% |
III.1 | 87 | FR3 | TAC | TAT | ASSynL226; ASPBLL2; BCSynL56; BCPBLL6, 8; ITPBLL25 | 17.7% |
III.1 | 94 | CDR3 | AGC | AAC | ASSynL227; ASPBLL10; BCPBLL4; LBPBLL4F, 4S; LKPBLL84; ITPBLL26 | 20.5% |
6S1 | 43 | FR2 | TCC | GCC | BCSynL1, 3, 38, 59; BCPBLL16; LBPBLL2S, 4; ITPBLL75 | 88.9% |