Table 1 Summary of α v integrin requirements during angiogenesis and in knockout mice during development
Model | Evidence for a role of α v integrins in angiogenesis (reference) |
|---|---|
Inhibitor Studies of α v Integrin Antagonists (antibodies, peptides, organics) | |
Chick | Block growth factor-induced angiogenesis on the CAM (47) Causes regression of human tumors on the CAM (25) |
Mouse | Inhibit Retinal vessel outgrowth (63) |
Rabbit | Inhibit Corneal micropocket angiogenesis (62) Arthritic knee angiogenesis, thereby reducing disease (73) Image tumors with antibody-coated liposomes as detected by MRI (74) |
Knockout Studies | |
αv knockout | Lethal because of defective brain and intestinal vessels (70) |
α3 knockout | No vascular defect suggests an αv integrin other than αvβ3 is required for brain and intestinal vessels (71) |