Fig. 1

Schematic domain organization of proteins with band 4.1 JEF domains. Examples of proteins with distinct domain organization are shown in six groups based on the sequence similarities of their band 4.1/JEF domain. Group I: JAK kinases; group II: FAK, PYK2, and KIAA0316, a non-characterized open reading frame; group III: talin, unconventional myosins, and plant kinesin-like calmodulin binding proteins (KCBP); group IV: the ERM proteins (ezrin, radixin, moesin) and the tumor suppressor merlin/schwannomin; group V: band 4.1, CDEP, and several protein tyrosine phosphatases (PTP); group VI: Expanded, a Drosophila protein, and PTP-BAS, which have no close relationship with each other or with other proteins in the sequence of their band 4.1/JEF domain. Additional domains include the tyrosine kinase domain (Tyr-kin), the kinase-like domain (kinase-like), a domain structurally related to the Src-homology 2 domain (SH2-L), the PSD95-Dlg-ZO1-homology domain (PDZ), the pleckstrin homology domain (PH), and the protein tyrosine phosphatase domain (PTP). Other characterized regions, including those involved in coiled-coil interactions or in actin binding are not indicated because their sequence and limits are less well defined than those of globular domains.