Table 2 Relationship of immunohistochemical results with various clinicopathological parameters
From: Alterations of p16-pRb Pathway and Chromosome Locus 9p21–22 in Sporadic Invasive Breast Carcinomas
Tumor Size (cm) | Lymph Node Metastasis | Grade | Stage | ER | PR | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IHC | <2 | 2 | >2 | p | No | Yes | p | I | II | III | p | I | II | III | IV | p | P | N | p | P | N | p |
p16 NE | 6 | 9 | 10 | 8 | 17 | 5 | 13 | 7 | 7 | 10 | 8 | 0 | 7 | 18 | 11 | 14 | ||||||
AE | 6 | 3 | 17 | 0.091 | 9 | 17 | 0.921 | 3 | 18 | 5 | 0.445 | 4 | 12 | 7 | 3 | 0.256 | 4 | 22 | 0.45 | 11 | 15 | 0.87 |
Total | 12 | 12 | 27 | 17 | 34 | 8 | 31 | 12 | 11 | 22 | 15 | 3 | 11 | 40 | 22 | 29 | ||||||
pRb NE | 8 | 8 | 22 | 8 | 30 | 7 | 22 | 9 | 7 | 16 | 11 | 4 | 8 | 30 | 18 | 20 | ||||||
AE | 6 | 4 | 6 | 0.340 | 9 | 7 | 0.026 | 2 | 11 | 3 | 0.749 | 5 | 7 | 4 | 0 | 0.460 | 3 | 13 | 0.85 | 4 | 12 | 0.22 |
Total | 14 | 12 | 28 | 17 | 37 | 9 | 33 | 12 | 12 | 23 | 15 | 4 | 11 | 43 | 22 | 32 | ||||||
p16/pRb NE/NE | 3 | 5 | 6 | 2 | 12 | 4 | 7 | 3 | 4 | 5 | 5 | 0 | 5 | 9 | 7 | 7 | ||||||
NE/AE | 3 | 4 | 3 | 5 | 5 | 1 | 6 | 3 | 3 | 4 | 3 | 0 | 1 | 9 | 3 | 7 | ||||||
AE/NE | 5 | 3 | 14 | 0.406 | 6 | 16 | 0.068 | 3 | 14 | 5 | 0.573 | 3 | 10 | 6 | 3 | 0.779 | 3 | 19 | 0.33 | 10 | 12 | 0.67 |
AE/AE | 1 | 0 | 3 | 3 | 1 | 0 | 4 | 0 | 1 | 2 | 1 | 0 | 1 | 3 | 1 | 3 | ||||||
Total | 12 | 12 | 26 | 16 | 34 | 8 | 31 | 11 | 11 | 21 | 15 | 3 | 10 | 40 | 21 | 29 | ||||||