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Fig. 1 | Molecular Medicine

Fig. 1

From: A Repression-derepression Mechanism Regulating the Transcription of Human Immunodeficiency Virus Type 1 In Primary T Cells

Fig. 1

HIV-1 LTR and derived target genes. (A) Relative position of relevant promoter elements within the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). (b) Sequence and position of oligonucleotides used as probes in the bandshift assays, and as cis-acting elements inserted into the hybrid promoter of target genes. The interleukin-2 (IL-2) consensus sequence is marked by a grey bar. (C) Map of target genes containing one or several copies of single cis-acting elements. In the ΔSp1 promoters, the elements are linked by an irrelevant spacer to a TATA box followed by the gene coding for chloramphenicol-acetyl-transferase (CAT) and a polyadenylation signal. In the Sp1 promoters, an Sp1 site is intercalated between the cis-active element(s) and the TATA box. NFAT, nuclear factor of activated T cells; NFκB, nuclear factor kappa B.

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Molecular Medicine

ISSN: 1528-3658