Fig. 6

The effect of hemin on vascular tension in preconstricted placental arteries. Human placental arteries were preconstricted with 100 nM U46619 (a thromboxane A2 mimetic) until steady state of tension was achieved. Thereafter, 5 µM hemin or vehicle was added. A typical recording trace showing the tension in response to hemin (solid line) and to vehicle alone (dashed line) is shown. The insert shows the effect of hemin at 30 min incubation timepoint on the mean change in tension induced by U46619. Data represent the mean ± S.E.M. of five separate experiments. *p < 0.01 vs U46619.