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Fig. 5 | Molecular Medicine

Fig. 5

From: Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis

Fig. 5

Effect of flavonoids on strand passage activity of Leishmania topoisomerase II. One µg of kinetoplast DNA was treated with Leishmania topoisomerase II (1 unit) in the absence (lane 2) and presence of 50 µM etoposide (lane 3) or flavonoids (lanes 4–10). Lanes 4 and 5, quercetin at 50 and 100 µM; lanes 6 and 7, luteolin at 12.5 and 50 µM; lane 8–10, flavoneA, rutin and isoorientin at 200 µM concentrations, respectively. Lane 11, 1 µg of kDNA digested with 1 unit of PstI.

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Molecular Medicine

ISSN: 1528-3658