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Table 3 In vivo anti-leishmanial activity of luteolin and quercetin

From: Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis

Treatment with

Dose (mg/kg Body Weight)

Amastigotes/100 Spleen Cell Nuclei

Total Parasite Load (× 108)

PBS

—

120.8 ± 65.6

1.1 ± 0.7

Luteolin

3.5

21.9 ± 16.9a

0.19 ± 0.12b

Quercetin

14.0

11.68 ± 13.0a

0.09 ± 0.13a

  1. a p < 0.04 versus PBS;
  2. b p < 0.05 versus PBS
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Molecular Medicine

ISSN: 1528-3658