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Table 1 Frequency of T-cell clones proliferating to PPD and mycobacterial HSP65

From: T Cells Recognize an Immunodominant Epitope of Heat Shock Protein 65 in Kawasaki Disease

 

Number (%) of Clones Reactive to

KD Patients (n = 5)

PPD

HSP65

#1 CD4 CD8

7/18 (39) 5/21 (24)

7/18 (39) 5/21 (24)

#2 CD4 CD8

11/21 (53) 6/16 (38)

10/21 (48) 5/16 (31)

#3 CD4 CD8

9/16 (56) 8/15 (53)

9/16 (56) 7/15 (47)

#4 CD4 CD8

5/14 (36) 5/13 (39)

5/14 (36) 5/13 (39)

#5 CD4 CD8

7/17 (42) 6/16 (38)

7/17 (42) 6/16 (38)

Total CD4

39/86 (45)

38/86 (44)

Total CD8

30/81 (37)

28/81 (34)

Healthy Controls (n = 5)

Total CD4

 

10/110 (9)

Total CD8

 

5/75 (7)

  1. Results represented in bold are statistically significant, compared with controls (p < 0.001). Proliferating clones were derived from different limiting dilution plates of different patients or controls. Only PPD-specific T-cell clones from controls subjects were tested for HSP65 reactivity in vitro. PPD, purified protein derivative; HSP65, heat shock protein 65.